| A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer |
Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration, Transvaginal Ultrasound |
Recruiting |
| Bio-Repository of High Risk Cohorts for the Early Detection of Pancreas Cancer |
Bio-Specimen Collection |
Recruiting |
| A Study of miRNA 371 in Patients With Germ Cell Tumors |
Biomarker Analysis, Blood Product Collection |
Recruiting |
| Esophageal Cancer Risk Registry |
Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies, Biopsy of esophageal/stomach tissue, lymph nodes, tumor, Blood specimen for non-DNA and DNA parts, Survey of client health, personal habits, family history |
Recruiting |
| Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer |
Biopsy, Biospecimen Collection, Bronchoscopy, Extended Release Metformin Hydrochloride, Questionnaire Administration |
Recruiting |
| Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis |
Biopsy, Biospecimen Collection, Computed Tomography, Defined Green Tea Catechin Extract, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Pharmacological Study, Questionnaire Administration, Ultrasound |
Active, not recruiting |
| GCC Agonist Signal in the Small Intestine |
Biopsy, Biospecimen Collection, Esophagogastroduodenoscopy, Linaclotide, Plecanatide |
Recruiting |
| Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia |
Biopsy, Biospecimen Collection, Extended Release Metformin Hydrochloride, Placebo Administration |
Recruiting |
| Testing Obeticholic Acid for Familial Adenomatous Polyposis |
Biopsy, Biospecimen Collection, Gastrointestinal Endoscopy, Obeticholic Acid, Placebo Administration, Questionnaire Administration |
Recruiting |
| Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial |
Biopsy, Biospecimen Collection, Mammography, Questionnaire Administration, Tamoxifen |
Not yet recruiting |
| Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial |
Biopsy, Biospecimen Collection, Placebo Administration, Urolithin A Supplement |
Not yet recruiting |
| Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients |
Biopsy, Calcipotriene, Fluorouracil |
Recruiting |
| Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer |
Biopsy, Extended Release Metformin Hydrochloride, Megestrol Acetate, Questionnaire Administration |
Recruiting |
| Testing ONC201 to Prevent Colorectal Cancer |
Biospecimen Collection, Biopsy, Colonoscopy, Sigmoidoscopy, Questionnaire Administration, Dordaviprone |
Not yet recruiting |
| Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers |
Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Placebo Administration, Questionnaire Administration |
Recruiting |
| Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters |
Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Placebo Administration, Questionnaire Administration, Training |
Recruiting |
| Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma |
Biospecimen Collection, Calaspargase Pegol, Levocarnitine, Pegaspargase, Quality-of-Life Assessment |
Recruiting |
| A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia |
Biospecimen Collection, Clinical Evaluation, Questionnaire Administration, Survey Administration |
Recruiting |
| A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for Primary Central Nervous System Tumors |
Biospecimen Collection, Cognitive Assessment, Magnetic Resonance Imaging, Memantine Hydrochloride, Placebo Administration, Questionnaire Administration |
Recruiting |
| Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis |
Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Placebo Administration, Questionnaire Administration, Simvastatin |
Active, not recruiting |