The Breast and Gynecologic Cancer Research Group conducts and fosters the development of research on the prevention and early detection of breast cancer, cervix and human papillomavirus (HPV)-related cancers, endometrial cancers, ovarian cancers, and precursor conditions related to these cancers.
Cancer Prevention Clinical Trials Network (CP-CTNet)
Research Centers develop and conduct early phase clinical trials to assess the preventive potential of agents and interventions of varying classes.
Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia)
Major medical research centers conduct systematic early clinical development of promising preventive agents.
US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network (ULACNet)
Partnership Centers will focus on improving prevention of human papillomavirus (HPV)-related cancers in human immunodeficiency virus (HIV)-infected individuals.
The ASCUS/LSIL Triage Study for Cervical Cancer (ALTS)
ALTS was a clinical trial to find the best way to help women and their doctors decide what to do about the mildly abnormal and very common Pap test results known as ASCUS and LSIL.
Research Highlights: Learning More about Breast Cancer Prevention in Primary Care Settings
This month’s Research Highlights focuses on provider and patient beliefs about mammogram screening frequency, and separately, provider barriers to engaging in shared decision-making with high-risk patients about the use of chemoprevention to reduce breast cancer risk.
Rising Endometrial Cancer Rates Spur New Approaches to Prevention
Unlike many other cancers, the incidence and death rates for uterine cancer are rising. Rates of new uterine cancer cases have risen 0.6% per year from 2010-2019, and death rates have risen an average of 1.7% per year for the same time frame.
Research Highlights: Learning More about How Breast Cancer Progresses
This issue of Research Highlights focuses on how cells progress to become breast cancer, and separately, how breast cancer may spread. Understanding these transitional moments can help researchers keep invasive cancer from forming, and help us keep invasive cancer from spreading. One study is about mapping the structural and functional patterns inside breast tissue that distinguish between...
Press Release: Enrollment in TMIST Breast Cancer Screening Trial Surpasses Halfway Mark; Recruitment of Women from Diverse Backgrounds is Key to Success
Philadelphia, March 25, 2022 — The Tomosynthesis Mammographic Imaging Screening Trial (TMIST), is more than halfway to its recruiting goal of 128,905 participants with more than 20% of participants in the United States being Black. Recruitment of women from diverse backgrounds is vital to ensuring that TMIST trial results will be applicable across races, ethnicities, and under-served communities.
Cancer Prevention and Screening: Progress Made and Progress to Come
NCI and CDC experts will discuss the importance of cancer prevention and screening for many cancers, the progress that has been made in the past 50 years in these fields, and share the successes of cervical cancer screening and prevention, including a focus on the human papillomavirus (HPV) vaccine.
Addressing a ‘Last Mile’ Problem in Cervical Cancer Screening
A presentation (PDF, 1.12 MB) from the 14th Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) - December 2-3, 2019 by Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Large Studies Evaluating How to Personalize Breast Cancer Screening for All Women
In the era of personalized medicine, prevention and screening for breast cancer are evolving toward new approaches that assess each woman’s risk and lifestyle factors.
How Precision Cancer Prevention Can Promote Health Equity
Overall, cancer death rates in the United States have been declining about 2% per year, current SEER data from 2014 through 2018 show. However, these improvements have not been experienced equally by everyone, which is one of the reasons that April is Minority Cancer Awareness Month, when we call attention to these disparities.
Variation in tumor-associated immune profiles and colorectal cancer outcomes
Considerable variability in tumor-associated immune responses exists across racial/ethnic populations. These variations may explain part of the observed disparities in response to cancer therapies, particularly immunotherapy, and treatment outcomes. In colorectal cancer (CRC), the intensity and composition of tumor infiltrating lymphocytes (TIL) are established prognostic and predictive...
Studies Focus on Testing Family Members of Cancer Gene Carriers
If your family member had cancer, would you want to know if you carried a gene mutation that increased your risk of the same cancer? This question is at the heart of three novel research projects underway to determine how best to connect with the family members of women with ovarian cancer so they can decide whether to get genetic testing and counseling about their own risk of cancer.
Study Seeks to Prevent Cancer and Extend Quality of Life for Women at Increased Genetic Risk of Ovarian Cancer
Researchers in gynecologic oncology have begun testing a promising surgery for premenopausal women at high genetic risk for ovarian cancer that avoids early menopause and may prevent these malignancies from developing.
Making Informed Choices on Incorporating Chemoprevention Into Breast Care: Q & A with Dr. Katherine Crew on the MiCHOICE Trial
The SWOG Cancer Research Network is opening to accrual the MiCHOICE Trial to study the use of decision support tools by women with high-risk breast conditions and their healthcare providers to choose among chemoprevention options. The MiCHOICE Trial was previously mentioned in the November 19 Cancer Prevention Science blog post How Patients and Their Doctors Determine Cancer Risk—and What...
How Patients and Their Doctors Determine Cancer Risk—and What Happens Next
If you were concerned that you might be at increased risk for a specific kind of cancer, what would you do to confirm that risk, and what would you be willing to do to reduce that risk? The answer is likely to be, "it depends on your doctor."
Projects Making Progress in Breast Cancer Detection and Prevention, By: Philip E. Castle
In the month of October, breast cancer awareness is the health message that looms large. Yet, researchers across the National Cancer Institute and across the world are focused on breast cancer all the time. In the United States, more than 275,000 women are expected to be diagnosed with breast cancer this year and more than 3.5 million are breast cancer survivors.
Research Issues in Gynecology and Women's Health: How do Benign Conditions Become Cancer?
Research to uncover how and why benign gynecologic conditions like endometriosis or uterine fibroids progress to invasive and deadly ovarian cancer or uterine sarcomas, is a critical and overlooked issue in women’s health. A new report on research priorities and an open funding opportunity are focused on addressing this issue.