The Chemopreventive Agent Development Research Group promotes and supports research on cancer preventive agent development, from preclinical studies to phase I clinical trials. The group’s projects aim to intercept the carcinogenic process by identifying and developing preventative agents with the potential to block, reverse, or delay the early stages of cancer. In addition, the group supports research on clinically translatable biomarkers that can be used to monitor tumor initiation and progression or assess efficacy of preventive interventions.

Read more About the Chemopreventive Agent Development Research Group.

Funding Opportunities

Active Grants

Clinical Trials



Cancer Prevention Clinical Trials Network (CP-CTNet)

Research Centers develop and conduct early phase clinical trials to assess the preventive potential of agents and interventions of varying classes.

More about the Cancer Prevention Clinical Trials Network (CP-CTNet)

PREVENT Cancer Preclinical Drug Development Program (PREVENT)

The peer-reviewed research pipeline supports new prevention interventions and biomarkers headed toward clinical trials.

Read more about the PREVENT Cancer Preclinical Drug Development Program (PREVENT)

Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia)

Major medical research centers conduct systematic early clinical development of promising preventive agents.

More about the Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia)

Agent Development Program Director Position Available

The National Cancer Institute (NCI), Division of Cancer Prevention (DCP), is seeking a Program Director to manage the formulation, production and distribution of small molecule and biologic agents for preclinical and clinical trials. As a Program Director, the candidate will have the opportunity to lead an innovative portfolio focused on preclinical and clinical agent development in the rapidly...

NCI Funding Approved to Expand Research on Immunoprevention, Natural Products

The National Cancer Institute’s (NCI’s) Board of Scientific Advisors (BSA) recently approved two new concept proposals aimed at expanding potential prevention interventions. One will strengthen research in the nascent field of immunoprevention, and the other will accelerate the development of novel natural products for intercepting cancer at the earliest stages of disease.

TEAG Forum: NCI Drug Development Resources: PREVENT and NExT Programs

The next Trans-NCI Extramural Awareness Group (TEAG) Forum will take place on February 13, 2023, from 11:00 a.m. to 12:00 p.m. ET. The event will be held virtually via WebEx and does not require registration to attend.

DCP/PREVENT-funded Project Presentations at the 2022 AACR Annual Meeting

NCI will participate in the American Association for Cancer Research (AACR) Annual Meetings 2022, which will be held on April 8-13, 2022, including DCP/PREVENT-funded project presentations.


Vaccine to Prevent Hereditary Cancers Nears Human Trials

One of the first-ever vaccines for the prevention of colorectal and other cancers in patients at high genetic risk for these malignancies is expected to start its early phase safety and immunogenicity trial in the first quarter of 2022, according to investigators.