Cancer Prevention Clinical Trials Network (CP-CTNet)

The Cancer Prevention Clinical Trials Network (CP-CTNet) performs early phase clinical trials to assess the safety, tolerability, and cancer preventive potential of agents and interventions of varying classes, many of which target molecules or processes known to be important during carcinogenesis. These trials include phase 0 (micro-dosing), phase I (dose-finding), and phase II (preliminary efficacy) clinical trials. The goal is to identify safe and effective preventive interventions in order to advance their further clinical development for cancer prevention.

This website is designed to help potential applicants find resources related to the two companion funding opportunity announcements (FOA) in support of CP-CTNet.

RFA Links

RFA-CA-18-029: Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required)

The CP-CTNet Sites will provide scientific leadership in development and conduct of early phase cancer prevention clinical trials as well as in the management and analysis of the data.

RFA-CA-18-030: Cancer Prevention Clinical Trials Network (CP-CTNet): Data Management, Auditing, and Coordinating Center (DMACC) (U24 Clinical Trials - Infrastructure)

The DMACC will support the CP-CTNet Sites and coordinate trans-Network activities with the following specific responsibilities: (i) centralized data management and data reporting, (ii) clinical trials auditing, and (iii) administrative and logistical coordination across CP-CTNet.

Informational Webinars

On Tuesday, October 2, 2018, two webinars will be held to provide information for potential applicants.

  1. A webinar for the CP-CTNet Sites (RFA-CA-18-029) will be held from 2-3 pm Eastern Time: Register and submit questions at: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=e23d6d27b6b0c8a03b1274497bc47cddd.
     
  2. The webinar for the CP-CTNet DMACC (RFA-CA-18-030) will be help from 3-4 pm Eastern Time: Register and submit questions at: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=e97543de3f8c392957239837c88f11c6c.

Background

The CP-CTNet Sites will provide scientific leadership in development and conduct of early phase cancer prevention clinical trials as well as in the management and analysis of the data. The DMACC will support the CP-CTNet Sites and coordinate trans-Network activities with the following specific responsibilities: (i) centralized data management and data reporting, (ii) clinical trials auditing, and (iii) administrative and logistical coordination across CP-CTNet.

Link to the CP-CTNet: Concept presentation to NCI Board of Scientific Advisors (BSA)

Program Information and Resources for Applicants

Information about 2012 Consortia Program

  • Phase 0/I/II Cancer Prevention Clinical Trials Program
    • 2012 Consortia Trials Standard Operating Procedures
    • 2012 Consortia Trials Instructions and Tools

Learn more about 2012 Consortia Program

Information and Resources for Centralized Data Management and Reporting

  • Medidata Rave® Data Capture & Management
  • DataIntegration Program
  • Accrual Quality Improvement and Tracking Program (AQuIP)
  • Cancer Data Standards Repository (caDSR)

More about Centralized Data Management and Reporting

DCP Contract Resources / Programs Supporting CP-CTNet

  • NCI Central Institutional Review Board (CIRB)
  • Regulatory Support Program
  • Drug Repository Program
  • Biorepository Program
  • Protocol Information Office (PIO) Support Program

Learn more about DCP Contract Resources

Administrative and Logistical Coordination

Annual Investigators' — Site Coordinators' Opportunity for Research Excellence (I-SCORE) Meeting Information

View past I-SCORE Meeting Information

Pre-application Webinar: Slides and Recording

  • Slide Presentation: Potential Applicant Webinar: Cancer Prevention Clinical Trials Network (CP-CTNet):
    CP-CTNet Sites RFA-CA-18-029 (PDF, 745 KB)
    Slide Recording (YouTube Video, 44:48)  
     
  • Slide Presentation: Potential Applicant Webinar: Cancer Prevention Clinical Trials Network (CP-CTNet): Data Management, Auditing, and Coordinating Center (DMACC)
    CP-CTNet DMACC RFA-CA-18-030 (PDF, 668 KB)
    Slide Recording (YouTube Video, 39:58)

 

Frequently Asked Questions (FAQs)

  • FAQs on RFA-CA-18-029
    Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1)
     
  • FAQs on RFA-CA-18-030
    Cancer Prevention Clinical Trials Network (CP-CTNet): Data Management, Auditing, and Coordinating Center (DMACC) (U24)

Last updated: October 26, 2018