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GCC Agonist Signal in the Small Intestine

Major Program

Cancer Prevention Clinical Trials Network

Research Group

Gastrointestinal and Other Cancers

Status

Active, not recruiting

NCT ID

NCT05107219

This early phase I trial studies the guanylyl cyclase C (GCC) agonist effect on cGMP signal in duodenal tissue. Plecanatide and linaclotide are drugs approved by the Food and Drug Administration for the treatment of conditions related to constipation. This trial aims to see the effects of taking either one of two drugs, plecanatide or linaclotide, or no drug, on a certain chemical found in the tissue collected from small intestine and how they compare.

Intervention

Biopsy, Biospecimen Collection, Esophagogastroduodenoscopy, Linaclotide, Plecanatide

Condition

Barrett Esophagus, Gastroesophageal Reflux Disease, Malignant Digestive System Neoplasm

Investigators

David S Weinberg, David S. Weinberg

CT Research Area

Prevention

See list of participating sites