Cancer Prevention Clinical Trials Network
Gastrointestinal and Other Cancers
National Cancer Institute (NCI)
For more information, see ClinicalTrials.gov NCT05107219
This early phase I trial studies the guanylyl cyclase C (GCC) agonist effect on cGMP signal in duodenal tissue. Plecanatide and linaclotide are drugs approved by the Food and Drug Administration for the treatment of conditions related to constipation. This trial aims to see the effects of taking either one of two drugs, plecanatide or linaclotide, or no drug, on a certain chemical found in the tissue collected from small intestine and how they compare.
Biopsy, Biospecimen Collection, Esophagogastroduodenoscopy, Linaclotide, Plecanatide
Barrett Esophagus, Gastroesophageal Reflux Disease
David S Weinberg, David S. Weinberg, Scott A. Waldman