Research Group
Gastrointestinal and Other Cancers
Sponsor
National Cancer Institute (NCI)
Status
Recruiting
NCT ID
NCT05630794
This phase I trial tests the safety, side effects, and best dose of ONC201 in preventing colorectal cancer in patients with familial adenomatous polyposis (FAP) or a history of multiple polyps. ONC201 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Intervention
Biopsy Procedure, Biospecimen Collection, Colonoscopy, Dordaviprone, Questionnaire Administration, Sigmoidoscopy
Condition
Colorectal Adenomatous Polyp, Colorectal Carcinoma, Familial Adenomatous Polyposis, Multiple Adenomatous Polyps
Investigators
Alexander G Raufi, Paul E. Wise, Peter P. Stanich, Elena M. Stoffel, Carol A. Burke
CT Research Area
Prevention