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Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

Research Group

Gastrointestinal and Other Cancers

Status

Recruiting

NCT ID

NCT05630794

This phase I trial tests the safety, side effects, and best dose of ONC201 in preventing colorectal cancer in patients with familial adenomatous polyposis (FAP) or a history of multiple polyps. ONC201 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Intervention

Biopsy Procedure, Biospecimen Collection, Colonoscopy, Dordaviprone, Questionnaire Administration, Sigmoidoscopy

Condition

Colorectal Adenomatous Polyp, Colorectal Carcinoma, Familial Adenomatous Polyposis, Multiple Adenomatous Polyps

Investigators

Alexander G Raufi, Paul E. Wise, Peter P. Stanich, Elena M. Stoffel, Carol A. Burke

CT Research Area

Prevention

See list of participating sites