Major Program
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
NRG Oncology
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT04251052
This clinical trial studies how well two surgical procedures (bilateral salpingectomy and
bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals
with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian
tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the
fallopian tubes and ovaries. This study may help doctors determine if the two surgical
procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1
mutations.
bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals
with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian
tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the
fallopian tubes and ovaries. This study may help doctors determine if the two surgical
procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1
mutations.
Intervention
Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, Quality-of-Life Assessment, Questionnaire Administration, Biospecimen Collection, Transvaginal Ultrasound
Condition
Ovarian Carcinoma
Investigators
Kathryn P Pennington, Gregory A. Masters, Georgina Cheng, Shannon MacLaughlan, Samir D. Undevia, Gustavo C. Rodriguez, John M. Schallenkamp, Nicola M. Spirtos, Eugenia Girda, Carolyn Y. Muller, Jeffrey W. Elder, David S. Miller, Kari L. Ring, Matthew L. Ryan, Lisa M. Barroilhet, William H. Bradley, Charles A. Leath, Ramey D. Littell, Beth Y. Karlan, Guilherme Henrique C. Cantuaria, Emma Barber, Kathryn A. Mills, David P. Bender, Leslie S. Bradford, Dana Zakalik, Ira S. Winer, Kathleen J. Yost, Emily N. Prendergast, Gretchen E. Glaser, Bryan A. Faller, Jay W. Carlson, Brent J. Tierney, Kerry J. Rodabaugh, Kara C. Long Roche, Richard G. Moore, Michael G. Kelly, Mariam M. AlHilli, Joan L. Walker, Alexander B. Olawaiye, Mark S. Shahin, Jennifer S. Wilbur, Carlton L. Schwab, Stephanie Sullivan, Setsuko K. Chambers, Scott E. Lentz, Lindsay Brubaker, Pamela J. Stone, Joyce Varughese, Sareena Singh, Koji Matsuo, Lee-May Chen, Linus T. Chuang, Beverly Long, Sharad A. Ghamande, Natalie S. Godbee, Sarah E. Gill, Michael E. Carney, Jean-Marie Stephan, Raanan Alter, Monica H. Vetter, Dana M. Roque, Andrea R. Hagemann, Marina Frimer, Marina Stasenko, Stephanie V. Blank, Jason D. Wright, Kevin Holcomb, Mary J. Cunningham, Amanda L. Jackson, Kimberly E. Resnick, Floor Backes, Timothy D. Moore, Sarah H. Kim, Gina M. Mantia Smaldone, Alaina J. Brown, Claire Hoppenot, Kathryn P. Pennington, Krista S. Pfaendler, Elmer G. Lehman, Matthew P. Schlumbrecht, Tashanna K. Myers, Kathryn Maurer, Neil T. Phippen, Gina L. Westhoff, Marguerite (Meg) L. Palisoul, Deanna G. Teoh, Elise J. Simons, Ismail Mert, Robert Neff, Sarah M. Crafton, Georgia A. McCann, Stephen H. Bush, Hui Chen, Shahzad Siddique, Nicole P. Chappell, Susan C. Modesitt, Barbara M. Buttin, Tara Castellano, Noah A. Goldman, Shashikant B. Lele, Angeles A. Secord, Nitya Alluri, Bethany Bustamante, Maureen R. Hewitt, Maria C. Bell, Rebecca D. Kaltman