Esophageal Cancer Risk Registry

University of Pittsburgh
Recruiting ID
For more information, see NCT00260585
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.
Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies, Biopsy of esophageal/stomach tissue, lymph nodes, tumor, Blood specimen for non-DNA and DNA parts, Survey of client health, personal habits, family history
Esophageal Cancer, Gastroesophageal Reflux Disease (GERD), Esophageal Diseases, Hiatal Hernia, Esophageal Achalasia
James D. Luketich, MD, Rajeev Dhupar, MD, Dongning Zhang, MD, Omar Awais, DO, Matthew Schuchert, MD, William Gooding, Tadeusz Witek, MD, Evan Alicuben, MD, Inderpal Sarkaria, MD, Ryan Levy, MD, Neil Christie, MD, Ernest Chan, MD, Vera Donnenberg, PhD, Olivera Finn, PhD, Angela Gallagher, CRNP, Arjun Pennathur, MD, James Luketich, MD, Nicholas Baker, MD, Julie Ward, BSN, Renee Levesque, MD, Navid Ajabshir, MD, Joel Greenberger, MD, Christian Otero, MD

See list of participating sites