HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network

NCI’s HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network is a cooperative agreement-funded program focused on pragmatic clinical trials to optimize the cervical cancer screening, management, and precancer treatment cascade for women living with HIV.

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About CASCADE

CASCADE is a global partnership focused on optimizing the cervical cancer screening, management, and pre-cancer treatment cascade for women living with HIV.

Visit the CASCADE Website

Funding Opportunities

See also the US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network (ULACNet) Funding Opportunities

Organizational Units

The ‘CASCADE’ Network consists of the following organizational units:

1 Network Coordinating Center

Organizational Unit

Principal Investigator(s)

Institution(s)

Grant No.

CASCADE Network Coordinating Center (CNCC)

Suzanne Siminski, M.S., M.B.A., and KyungMann Kim, Ph.D.

Frontier Science, with
University of Wisconsin

U24CA275417

supported via RFA-CA-21-045

3 Research Bases

Organizational Unit

Principal Investigator(s)

Institution(s)

Grant No.

Research Base 1 (RB1)

Rachel Winer, Ph.D., M.P.H. and
Elizabeth Brown, Sc.D., M.S.

University of Washington, with
Fred Hutchinson Cancer Research Center

UG1CA275402

Research Base 2 (RB2)

Timothy Wilkin, M.D., M.P.H., Anna Giuliano, Ph.D., and
Carla Chibwesha, M.D., M.Sc.

University of California San Diego with Moffitt Cancer Center and University of North Carolina at Chapel Hill

UG1CA275414

Research Base 3 (RB3)

Jennifer Smith, Ph.D., M.P.H., Michael Hudgens, Ph.D., and Lameck Chinula, M.D., M.P.H.

University of North Carolina at Chapel Hill

UG1CA275403

supported via RFA-CA-21-046

9 Clinical Sites

Organizational Unit

Principal Investigator(s)

Institution(s)

Grant No.

Clinical Trials Site 1 (CS1): Uganda

Betty Mwesigwa, M.B.Ch.B., M.Sc.

Makerere University Walter Reed Project, with US Military HIV Research Program and Uganda Cancer Institute

UG1CA275412

Clinical Trials Site 2 (CS2): Kenya

Michael Chung, M.D., Ph.D., M.P.H. and Samah Sakr, M.B.Ch.B.

Emory University, with Coptic Hope Center for Infectious Diseases and Kenyatta National Hospital

UG1CA275400

Clinical Trials Site 3 (CS3): Botswana

Scott Dryden-Peterson, M.D., M.S. and Doreen Ramogola-Masire, M.B.B.S., Ph.D., M.P.H.

Brigham and Women's Hospital, with Botswana Harvard AIDS Institute Partnership

UG1CA275416

Clinical Trials Site 4 (CS4): US/Georgia

Lisa Flowers, M.D., M.P.H. and

Anandi Sheth, M.D., M.Sc.

 

Emory University

UG1CA284884

Clinical Trials Site 5 (CS5): Rwanda

Gad Murenzi, M.D., M.S., Kathryn Anastos, M.D., and Rubagumya Fidel, M.D., M.P.H.

 

Research for Development, Albert Einstein College of Medicine, with Rwanda Military Hospital

UG1CA284908

Clinical Trials Site 6 (CS6): Kenya

Nelly Mugo, M.B.Ch.B., M.P.H., and Kenneth Ngure, Ph.D., M.P.H., M.Sc.

 

Kenya Medical Research Institute (KEMRI), with Jomo Kenyatta University of Agriculture and Technology

UG1CA285132

Clinical Trials Site 7 (CS7): Zimbabwe

Chirenje Zvavahera, M.D., and Bothwell Guzha, M.B.Ch.B, M.Phil

 

University of California, San Francisco, with University of Zimbabwe

UG1CA284918

Clinical Trials Site 8 (CS8): US/Maryland

Clement Adebamowo, B.M.Ch.B., Sc.D., and Gregory Taylor, M.D.

 

University of Maryland, Baltimore

UG1CA284883

Clinical Trials Site 9 (CS9): South Africa

Nivashnee Naicker, M.D., M.P.H, M.A.S.

Centre for the AIDS Programme of Research in South Africa (CAPRISA)

UG1CA284671

three sites supported via RFA-CA-21-047; six additional sites supported via RFA-CA-22-051

Unified Network Initiative to Enhance Community Dialogue and Site Education (UNITED)

UNITED provides a dynamic framework for both ULACNet and CASCADE to promote activities that build shared trust between researchers and communities, and to ensure that research outcomes and benefits are disseminated to study participants and the broader community.

UNITED will enhance both the ULACNet and CASCADE networks by:

  1. Providing a forum for network members to share knowledge and lessons learned on effective strategies for enhancing study recruitment and community engagement;
     
  2. Providing training and educational opportunities for CASCADE and ULACNet members; and
     
  3. Providing clinical trial resources for network study participants, their families, and the public.

Learn more about UNITED and view recordings of community engagement sessions

Program Contact(s)

Email: cascade@nih.gov
Phone: 240-276-7332
Fax: 240-276-7828

Program Director

Vikrant Sahasrabuddhe, M.B.B.S., Dr.P.H.
Email: vikrant.sahasrabuddhe@nih.gov