NCI’s 'CASCADE' Clinical Trials Network is a cooperative agreement–funded program focused on generating evidence to optimize the HPV-associated cancer prevention cascade (screening, management, and precancer treatment) in individuals with HIV.
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The ‘CASCADE’ Network Consists of 3 Organizational Units
1 ‘CASCADE’ Network Coordinating Center (CNCC)
| Organizational Unit | Principal Investigator(s) | Institution(s) | Grant No. |
|---|---|---|---|
| CASCADE Network Coordinating Center (CNCC) | Suzanne Siminski, M.S., M.B.A. | Frontier Science Foundation, with University of Wisconsin and University of California Los Angeles | U24CA275417 |
supported via RFA-CA-21-045
3 Research Bases (RB)
| Organizational Unit | Principal Investigator(s) | Institution(s) | Grant No. |
|---|---|---|---|
| Research Base 1 (RB1) | Rachel Winer, Ph.D., M.P.H., Elizabeth Brown, Sc.D., M.S., and Leeya Pinder, M.D., M.P.H. | University of Washington, with Fred Hutchinson Cancer Research Center and University of Cincinnati | UG1CA275402 |
| Research Base 2 (RB2) | Timothy Wilkin, M.D., M.P.H., Anna Giuliano, Ph.D., and Carla Chibwesha, M.D., M.Sc. | University of California San Diego, with Moffitt Cancer Center, University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, and University of California San Francisco | UG1CA275414 |
| Research Base 3 (RB3) | Jennifer Smith, Ph.D., M.P.H., Michael Hudgens, Ph.D., and Lameck Chinula, M.D., M.P.H. | University of North Carolina at Chapel Hill | UG1CA275403 |
supported via RFA-CA-21-046
9 Clinical Sites (CS)
| Organizational Unit | Principal Investigator(s) | Institution(s) | Grant No. |
|---|---|---|---|
| Clinical Trials Site 1 (CS1): Uganda | Betty Mwesigwa, M.B.Ch.B., M.Sc. | Makerere University Walter Reed Program, with US Military HIV Research Program | UG1CA275412 |
| Clinical Trials Site 2 (CS2): Kenya | Michael Chung, M.D., Ph.D., M.P.H. and Samah Sakr, M.B.Ch.B. | Emory University, with Coptic Hope Center for Infectious Diseases | UG1CA275400 |
| Clinical Trials Site 3 (CS3): Botswana | Scott Dryden-Peterson, M.D., M.S. and Doreen Ramogola-Masire, M.B.B.S., Ph.D., M.P.H. | Brigham and Women's Hospital, with Botswana Harvard AIDS Partnership (BHP) and Beth Israel Deaconess Medical Center | UG1CA275416 |
| Clinical Trials Site 4 (CS4): US/Georgia | Lisa Flowers, M.D., M.P.H. and Anandi Sheth, M.D., M.Sc. | Emory University, with Morehouse School of Medicine, Horizons Community Solutions, University of Puerto Rico Comprehensive Cancer Center, and University of Puerto Rico School of Medicine | UG1CA284884 |
| Clinical Trials Site 5 (CS5): Rwanda | Fidel Rubagumya, M.D., M.P.H. | Research for Development, with Albert Einstein College of Medicine | UG1CA284908 |
| Clinical Trials Site 6 (CS6): Kenya | Nelly Mugo, M.B.Ch.B., M.P.H., and Kenneth Ngure, Ph.D., M.P.H., M.Sc. | Kenya Medical Research Institute (KEMRI), with LVCT Health | UG1CA285132 |
| Clinical Trials Site 7 (CS7): Zimbabwe | Zvavahera Chirenje, M.D., and Bothwell Guzha, M.B.Ch.B, M.Phil | University of California San Francisco, with University of Zimbabwe | UG1CA284918 |
| Clinical Trials Site 8 (CS8): US/Maryland | Clement Adebamowo, B.M.Ch.B., Sc.D., and Gregory Taylor, M.D. | University of Maryland Baltimore, with Albert Einstein College of Medicine and Weill Cornell College of Medicine | UG1CA284883 |
| Clinical Trials Site 9 (CS9): South Africa | Nivashnee Naicker, M.D., M.P.H, M.A.S. | Centre for the AIDS Programme of Research in South Africa (CAPRISA) | UG1CA284671 |
three sites supported via RFA-CA-21-047; six additional sites supported via RFA-CA-22-051
Funding Opportunities
Related Funding Opportunities and Training Resources for CASCADE Grantees.
Unified Network Initiative to Enhance Community Dialogue and Site Education (UNITED)
UNITED provides a dynamic framework for both ULACNet and CASCADE to promote activities that build shared trust between researchers and communities, and to ensure that research outcomes and benefits are disseminated to study participants and the broader community.
UNITED will enhance both the ULACNet and CASCADE networks by:
- Providing a forum for network members to share knowledge and lessons learned on effective strategies for enhancing study recruitment and community engagement;
- Providing training and educational opportunities for CASCADE and ULACNet members; and
- Providing clinical trial resources for network study participants, their families, and the public.
Learn more about UNITED and view recordings of community engagement sessions
Program Contact(s)
Email: cascade@nih.gov
Phone: 240-276-7332
Fax: 240-276-7828
Program Director
Vikrant Sahasrabuddhe, M.B.B.S., Dr.P.H.
Email: vikrant.sahasrabuddhe@nih.gov