Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
Children's Oncology Group
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT04939597
This phase III trial compares memantine to placebo in treating patients with primary central nervous system tumors. Memantine may block receptors (parts of nerve cells) in the brain known to contribute to a decline in cognitive function. Giving memantine may make a difference in cognitive function (attention, memory, or other thought processes) in children and adolescents receiving brain radiation therapy to treat a primary central nervous system tumors.
Intervention
Biospecimen Collection, Cognitive Assessment, Magnetic Resonance Imaging, Memantine Hydrochloride, Placebo Administration, Questionnaire Administration
Condition
Central Nervous System Carcinoma
Investigators
Nadia N Laack, Nadia N. Laack, Site Public Contact, Wendy S. Darlington, Peter D. Cole, Clare J. Twist, Eugene Suh, Michael S. Isakoff, Barbara A. Gruner, Mark A. Ranalli, David S. Dickens, Lauren R. Weintraub, James T. Felker, Jason M. Fixler, Judy L. Felgenhauer, Craig Lotterman, Andrea T. Franson, Robert G. Irwin, Kenneth J. Cohen, Jagadeesh Ramdas, Jessica M. Sun, Scott M. Bradfield, Jamie L. Dargart, Brenda J. Wittman, Emad K. Salman, Laura E. Agresta, Alissa Kahn, Kayelyn J. Wagner, Michael K. Richards, Holly E. Pariury, William S. Ferguson, Elyssa M. Rubin, Adam J. Esbenshade, Stephanie A. Toll, Samuel J. Milanovich, Sarah E. Leary, Andrew J. Galligan, Rene Y. McNall-Knapp, Aarati V. Rao, Nicole J. Ullrich, Wade T. Kyono, Don E. Eslin, Sameer Farouk Sait, Ashley E. Meyer, William D. Roberts, Martha M. Pacheco, Daniel C. Bowers, Jacqueline N. Casillas, Daniel Willis, Melissa A. Forouhar, Sandeep Batra, Kelsey Bertrand, Jill C. Beck, Alyssa T. Reddy, Timothy J. Harris, Samantha L. Mallory, Peter M. de Blank, Eric J. Lowe, Jennifer A. Domm, Tobey J. MacDonald, Douglas J. Scothorn, Andrea R. Whitfield, Jennifer J. Clark, Erwood G. Edwards, Albert Kheradpour, Alan K. Ikeda, David E. Kram, Mary S. Huang, Kathryn L. Laurie, Linda C. Stork, Nadav L. Kastle, Jay Michael S. Balagtas, Gregory E. Halligan, Joseph C. Torkildson, David L. Becton, Joel A. Kaplan, Nibal A. Zaghloul, Lolie C. Yu, Stuart L. Cramer, Jeffrey S. Dome, Aniket Saha, Lisa A. Mueller, Allen I. Stering, Prerna Kumar, Thomas W. McLean, Erin Wright, Jose M. Esquilin, Najat C. Daw, Shannon M. Cohn, Derek R. Hanson, Kathleen J. Yost, Robin D. Hanson, Duncan S. Stearns, Sibo Zhao, Laura E. Hogan, Betty L. Herrington, Keith J. August, Mahmut Y. Celiker, Karen S. Fernandez, Priya Chan, Benjamin Carcamo, Matthew D. Hall, David R. Freyer, Elizabeth A. Raetz, Jacob A. Troutman, Jason M. Glover, Dipti S. Dighe, Angela Ricci, Julie Voeller, Sarah Rumler, Jordan M. Wright, Bradley DeNardo, Nicholas J. Pytel, Melanie A. Comito, Shafqat Shah, Stacie L. Stapleton, Brian Stover, Susan E. Spiller, Michael J. Ferguson, Holly B. Lindsay, Caroline A. Hastings, Matteo M. Trucco, Bradley Gampel, Pamela R. Merola, Michael R. Mangum