A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Major Program(s) or Research Group(s)

  • Community Oncology and Prevention Trials
  • NCI Community Oncology Research Program
  • Supportive Care and Symptom Management

Sponsor

Children's Oncology Group

Status

Recruiting

ClinicalTrials.gov ID

For more information, see ClinicalTrials.gov NCT04939597

This phase III trial compares memantine to usual treatment in treating patients with brain
tumors that are newly diagnosed or has come back (recurrent). Memantine may block receptors
(parts of nerve cells) in the brain known to contribute to a decline in cognitive function.
Giving memantine may make a difference in cognitive function (attention, memory, or other
thought processes) in children and adolescents receiving brain radiation therapy to treat a
primary brain tumor.

Intervention

Cognitive Assessment, Memantine Hydrochloride, Placebo Administration

Condition

Brain Neoplasm, Recurrent Brain Neoplasm

Investigators

Nadia N Laack, Eric J. Lowe, Girish Dhall, William D. Roberts, Scott M. Bradfield, Wade T. Kyono, Sandeep Batra, David S. Dickens, Kathleen J. Yost, Nadia N. Laack, Anderson (Andy) B. Collier, Keith J. August, Clare J. Twist, Philip M. Monteleone, Mukund G. Dole, James T. Felker

See list of participating sites