Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
Children's Oncology Group
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT04939597
This phase III trial compares memantine to usual treatment in treating patients with brain
tumors that are newly diagnosed or have come back (recurrent). Memantine may block receptors
(parts of nerve cells) in the brain known to contribute to a decline in cognitive function.
Giving memantine may make a difference in cognitive function (attention, memory, or other
thought processes) in children and adolescents receiving brain radiation therapy to treat a
primary brain tumor.
tumors that are newly diagnosed or have come back (recurrent). Memantine may block receptors
(parts of nerve cells) in the brain known to contribute to a decline in cognitive function.
Giving memantine may make a difference in cognitive function (attention, memory, or other
thought processes) in children and adolescents receiving brain radiation therapy to treat a
primary brain tumor.
Intervention
Cognitive Assessment, Memantine Hydrochloride, Placebo Administration
Condition
Brain Neoplasm, Recurrent Brain Neoplasm
Investigators
Nadia N Laack, Eric J. Lowe, Girish Dhall, William D. Roberts, Scott M. Bradfield, Wade T. Kyono, Sandeep Batra, David S. Dickens, Kathleen J. Yost, Nadia N. Laack, Anderson (Andy) B. Collier, Keith J. August, Clare J. Twist, Philip M. Monteleone, Mukund G. Dole, Aarati V. Rao, Alyssa T. Reddy, Don E. Eslin, Eugenia Chang, Mary L. Schmidt, Nicole J. Ullrich, Laura E. Agresta, Alissa Kahn, Lauren R. Weintraub, Thomas W. McLean, Peter M. de Blank, Mark A. Ranalli, Rene Y. McNall-Knapp, Janice F. Olson, Kelsey Bertrand, Daniel C. Bowers, Sibo Zhao, Jose M. Esquilin, Anne-Marie R. Langevin, Kenneth B. De Santes, Elyssa M. Rubin, Jennifer J. Clark, Michael S. Isakoff, Matthew D. Hall, Ashok B. Raj, Andrea T. Franson, Lisa Gennarini, Gary D. Crouch, Andrea R. Whitfield, Jamie L. Dargart, Gregory E. Halligan, Stuart L. Cramer, Aniket Saha, Adam J. Esbenshade, Shannon M. Cohn, Ranjan Bista, Melissa A. Forouhar, Lindsey M. Hoffman, Kathleen M. Dorris, Eugene Suh, Craig Lotterman, Michael K. Richards, Derek R. Hanson, Nibal A. Zaghloul, Mahmut Y. Celiker, Mark P. Atlas, Laura E. Hogan, Erin Wright, James T. Felker, Jennifer A. Domm, Timothy C. Griffin, Luke D. Maese, Michelle A. Manalang, Brenda J. Wittman, Joseph C. Torkildson, Holly E. Pariury, David L. Becton, Lisa A. Mueller, Leo Mascarenhas, Karen S. Fernandez, Jeffrey S. Dome, Emad K. Salman, William B. Slayton, Ziad A. Khatib, Samantha L. Mallory, Nadav L. Kastle, Jason M. Fixler, Kenneth J. Cohen, Stephanie A. Toll, Barbara A. Gruner, William S. Ferguson, Robin D. Hanson, Jill C. Beck, Kathryn L. Laurie, Sharon L. Gardner, Sameer Farouk Sait, Lars M. Wagner, Samuel J. Milanovich, Duncan S. Stearns, Rabi Hanna, Linda C. Stork, Jennifer J. Welch, Kayelyn J. Wagner, Susan E. Spiller, Najat C. Daw, Timothy J. Harris, Erwood G. Edwards, Sarah E. Leary, Judy L. Felgenhauer, Robert G. Irwin, Jhon A. Guerra, Jay Michael S. Balagtas, Tobey J. MacDonald, Wendy S. Darlington, Lolie C. Yu, Laura K. Gowans, Alan K. Ikeda, Jacob A. Troutman, Prerna Kumar, Mary S. Huang, Ashley E. Meyer