This randomized phase II trial studies the effects of aspirin and zileuton on genes related to tobacco use in current smokers. Aspirin and zileuton may interfere with genes related to tobacco use and may be useful in preventing lung cancer in current smokers.
Intervention
Aspirin, Laboratory Biomarker Analysis, Placebo, Zileuton
Condition
Current Every Day Smoker, Multiple Pulmonary Nodules, Tobacco Smoking, Tobacco Use Disorder
Investigators
Linda L. Garland, Jun Yan, Avrum Spira