Principal Investigator

Brad H
Pollock
Awardee Organization

Public Health Institute
United States

Fiscal Year
2022
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Towards a preventive cancer vaccine for children with constitutional mismatch repair deficiency

In children, DNA replication repair deficiency (RRD), caused by mutations in the mismatch repair of DNA polymerase genes, is an important cancer mechanism. RRD drives a deadly group of cancers universally characterized by hypermutation, microsatellite instable (MSI) in/dels and resistance to chemoradiation. Children with germline/constitutional mismatch repair deficiency (CMMRD) have the highest burden of cancers in humans and rarely reach adulthood. The exceptionally high number of mutations creates highly immunogenic peptides never expressed in normal cells called neoantigens. Clinical evidence for the importance of CD8+ T cell activation in endogenous neoantigen immune surveillance is demonstrated by immune checkpoint inhibitor (ICI) immunotherapy efficacy. While the success of ICI has led to speculation that they may also be helpful for primary cancer prevention, ICI also has significant rates of severe adverse events, including autoimmunity-related lung, hepatic, skin, neuro, colon, endocrine, and lymphoma toxicities, some of which are fatal. These problems have led to new interest in cancer immunoprevention vaccines, which have milder and fewer adverse events, to boost cancer neoantigen immune surveillance. Recently, lipid nanoparticle RNA (LNP-RNA) vaccines against COVID-19 demonstrated convincingly that LNP-RNA vaccination is faster, more flexible, cheaper and more immunogenic than any previous vaccine technology. Our overall goal is to leverage paradigm-shifting advances in molecular diagnosis of CMMRD children as an identifiable highrisk patient group, a mechanistic understanding of CMMRD derived RRD tumor mutation architecture, powerful advances in tumor genomics and recent advances in vaccine technology to pre-clinically discover, formulate, and validate novel LNP RNA vaccines for effective and safe CMMRD pediatric immunoprevention.

Publications

  • Kelly MJ, Sung L, Dickens DS. Barriers to Medication Access in Pediatric Oncology in the United States. Journal of pediatric hematology/oncology. 2019 May;41(4):286-288. PMID: 30124549
  • Guilcher GMT, Rivard L, Huang JT, Wright NAM, Anderson L, Eissa H, Pelletier W, Ramachandran S, Schechter T, Shah AJ, Wong K, Chow EJ. Immune function in childhood cancer survivors: a Children's Oncology Group review. The Lancet. Child & adolescent health. 2021 Apr;5(4):284-294. Epub 2021 Feb 16. PMID: 33600774
  • Roth ME, Parsons SK, Ganz PA, Wagner LI, Hinds PS, Alexander S, Bingen K, Bober SL, Brackett J, Cella D, Henry NL, Indelicato DJ, Johnson RH, Miller TP, Rosenberg SM, Schmitz KH, Thanarajasingam G, Reeve BB, Salsman JM. Inclusion of a core patient-reported outcomes battery in adolescent and young adult cancer clinical trials. Journal of the National Cancer Institute. 2023 Jan 10;115(1):21-28. PMID: 36266760
  • Haase JE, Robb SL, Burns DS, Stegenga K, Cherven B, Hendricks-Ferguson V, Roll L, Docherty SL, Phillips C. Adolescent/Young Adult Perspectives of a Therapeutic Music Video Intervention to Improve Resilience During Hematopoietic Stem Cell Transplant for Cancer. Journal of music therapy. 2020 Feb 25;57(1):3-33. PMID: 31802124
  • Pollock BH. What's Missing in the Assessment of Adolescent and Young Adult (AYA) Cancer Outcomes? Journal of the National Cancer Institute. 2020 Oct 1;112(10):975-976. PMID: 32123919
  • Bhatia S, Landier W, Hageman L, Kim H, Chen Y, Crews KR, Evans WE, Bostrom B, Casillas J, Dickens DS, Maloney KW, Neglia JP, Ravindranath Y, Ritchey AK, Wong FL, Relling MV. 6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study. Blood. 2014 Oct 9;124(15):2345-53. Epub 2014 May 14. PMID: 24829202
  • Miller TP, Troxel AB, Li Y, Huang YS, Alonzo TA, Gerbing RB, Hall M, Torp K, Fisher BT, Bagatell R, Seif AE, Sung L, Gamis A, Rubin D, Luger S, Aplenc R. Comparison of administrative/billing data to expected protocol-mandated chemotherapy exposure in children with acute myeloid leukemia: A report from the Children's Oncology Group. Pediatric blood & cancer. 2015 Jul;62(7):1184-9. Epub 2015 Mar 11. PMID: 25760019
  • Miller TP, Marx MZ, Henchen C, DeGroote NP, Jones S, Weiland J, Fisher B, Esbenshade AJ, Aplenc R, Dvorak CC, Fisher BT. Challenges and Barriers to Adverse Event Reporting in Clinical Trials: A Children's Oncology Group Report. Journal of patient safety. 2022 Apr 1;18(3):e672-e679. PMID: 34570002
  • Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV. Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait. Clinical pharmacology and therapeutics. 2017 Mar;101(3):373-381. Epub 2016 Nov 18. PMID: 27564568
  • Minasian LM, Frazier AL, Sung L, O'Mara A, Kelaghan J, Chang KW, Krailo M, Pollock BH, Reaman G, Freyer DR. Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials. Cancer medicine. 2018 Jul;7(7):2951-2959. Epub 2018 May 30. PMID: 29846043
  • Bradfield SM, Sandler E, Geller T, Tamura RN, Krischer JP. Glutamic acid not beneficial for the prevention of vincristine neurotoxicity in children with cancer. Pediatric blood & cancer. 2015 Jun;62(6):1004-10. Epub 2014 Dec 24. PMID: 25545757
  • van der Kooi ALF, Mulder RL, Hudson MM, Kremer LCM, Skinner R, Constine LS, van Dorp W, van Dulmen-den Broeder E, Winther JF, Wallace WH, Waugh J, Woodruff TK, Anderson RA, Armenian SH, Bloemenkamp KWM, Critchley HOD, Demoor-Goldschmidt C, Ehrhardt MJ, Green DM, Grobman WA, Iwahata Y, Krishna I, Laven JSE, Levitt G, Meacham LR, Miller ES, Mulders A, Polanco A, Ronckers CM, Samuel A, Walwyn T, Levine JM, van den Heuvel-Eibrink MM. Counseling and surveillance of obstetrical risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. American journal of obstetrics and gynecology. 2021 Jan;224(1):3-15. Epub 2020 Jun 2. PMID: 32502557
  • Dvorak CC, Fisher BT, Esbenshade AJ, Nieder ML, Alexander S, Steinbach WJ, Dang H, Villaluna D, Chen L, Skeens M, Zaoutis TE, Sung L. A Randomized Trial of Caspofungin vs Triazoles Prophylaxis for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplant. Journal of the Pediatric Infectious Diseases Society. 2021 Apr 30;10(4):417-425. PMID: 33136159
  • Siembida EJ, Loomans-Kropp HA, Tami-Maury I, Freyer DR, Sung L, Crosswell HE, Pollock BH, Roth ME. Barriers and Facilitators to Adolescent and Young Adult Cancer Trial Enrollment: NCORP Site Perspectives. JNCI cancer spectrum. 2021 Mar 22;5. (3). doi: 10.1093/jncics/pkab027. eCollection 2021 Jun. PMID: 34104866
  • Minasian L, Dimond E, Davis M, Adhikari B, Fagerstrom R, Fabian C, Floyd J, Unger JM, Douglas PS, Mustian KM, Chow EJ, Lipshultz S, Hundley WG, Armenian S, Ky B. The Evolving Design of NIH-Funded Cardio-Oncology Studies to Address Cancer Treatment-Related Cardiovascular Toxicity. JACC. CardioOncology. 2019 Sep;1(1):105-113. Epub 2019 Sep 24. PMID: 32529192
  • Bowers DC, Verbruggen LC, Kremer LCM, Hudson MM, Skinner R, Constine LS, Sabin ND, Bhangoo R, Haupt R, Hawkins MM, Jenkinson H, Khan RB, Klimo P Jr, Pretorius P, Ng A, Reulen RC, Ronckers CM, Sadighi Z, Scheinemann K, Schouten-van Meeteren N, Sugden E, Teepen JC, Ullrich NJ, Walter A, Wallace WH, Oeffinger KC, Armstrong GT, van der Pal HJH, Mulder RL. Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. The Lancet. Oncology. 2021 May;22(5):e196-e206. Epub 2021 Apr 9. PMID: 33845037
  • Singh P, Wang X, Hageman L, Chen Y, Magdy T, Landier W, Ginsberg JP, Neglia JP, Sklar CA, Castellino SM, Dreyer ZE, Hudson MM, Robison LL, Blanco JG, Relling MV, Burridge P, Bhatia S. Association of GSTM1 null variant with anthracycline-related cardiomyopathy after childhood cancer-A Children's Oncology Group ALTE03N1 report. Cancer. 2020 Sep 1;126(17):4051-4058. Epub 2020 May 15. PMID: 32413235
  • Bhatia S, Landier W, Hageman L, Chen Y, Kim H, Sun CL, Kornegay N, Evans WE, Angiolillo AL, Bostrom B, Casillas J, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Wong FL, Relling MV. Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. JAMA oncology. 2015 Jun;1(3):287-95. PMID: 26181173
  • Armenian SH, Hudson MM, Chen MH, Colan SD, Lindenfeld L, Mills G, Siyahian A, Gelehrter S, Dang H, Hein W, Green DM, Robison LL, Wong FL, Douglas PS, Bhatia S. Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure. BMC cardiovascular disorders. 2016 Oct 4;16(1):187. PMID: 27716152
  • Getz KD, Miller TP, Seif AE, Li Y, Huang YS, Alonzo T, Gerbing R, Sung L, Hall M, Bagatell R, Gamis A, Fisher BT, Aplenc R. Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report. Cancer medicine. 2016 Sep;5(9):2412-6. Epub 2016 Jul 29. PMID: 27474232
  • Schofield HT, Fabrizio VA, Braniecki S, Pelletier W, Eissa H, Murphy B, Chewning J, Barton KD, Embry LM, Levine JE, Schultz KR, Page KM. Monitoring Neurocognitive Functioning After Pediatric Cellular Therapy or Hematopoietic Cell Transplant: Guidelines From the COG Neurocognition in Cellular Therapies Task Force. Transplantation and cellular therapy. 2022 Oct;28(10):625-636. Epub 2022 Jul 21. PMID: 35870778
  • Tramsen L, Salzmann-Manrique E, Bochennek K, Klingebiel T, Reinhardt D, Creutzig U, Sung L, Lehrnbecher T. Lack of Effectiveness of Neutropenic Diet and Social Restrictions as Anti-Infective Measures in Children With Acute Myeloid Leukemia: An Analysis of the AML-BFM 2004 Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Aug 10;34(23):2776-83. Epub 2016 Jun 6. PMID: 27269945
  • Loeffen EAH, Kremer LCM, Mulder RL, Font-Gonzalez A, Dupuis LL, Sung L, Robinson PD, van de Wetering MD, Tissing WJE. The importance of evidence-based supportive care practice guidelines in childhood cancer-a plea for their development and implementation. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2017 Apr;25(4):1121-1125. Epub 2016 Dec 8. PMID: 27928642
  • Freyer DR, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. The Lancet. Oncology. 2017 Jan;18(1):63-74. Epub 2016 Dec 1. PMID: 27914822
  • Knight KR, Chen L, Freyer D, Aplenc R, Bancroft M, Bliss B, Dang H, Gillmeister B, Hendershot E, Kraemer DF, Lindenfeld L, Meza J, Neuwelt EA, Pollock BH, Sung L. Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Feb;35(4):440-445. Epub 2016 Dec 12. PMID: 27937095
  • Bhatia S, Hageman L, Chen Y, Wong FL, McQuaid EL, Duncan C, Mascarenhas L, Freyer D, Mba N, Aristizabal P, Walterhouse D, Lew G, Kempert PH, Russell TB, McNall-Knapp RY, Jacobs S, Dang H, Raetz E, Relling MV, Landier W. Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA network open. 2020 Aug 3;3(8):e2014205. PMID: 32852553
  • Vujkovic M, Aplenc R, Alonzo TA, Gamis AS, Li Y. Comparing Analytic Methods for Longitudinal GWAS and a Case-Study Evaluating Chemotherapy Course Length in Pediatric AML. A Report from the Children's Oncology Group. Frontiers in genetics. 2016 Aug 5;7:139. doi: 10.3389/fgene.2016.00139. eCollection 2016. PMID: 27547214
  • Getz KD, Li Y, Alonzo TA, Hall M, Gerbing RB, Sung L, Huang YS, Arnold S, Seif AE, Miller TP, Bagatell R, Fisher BT, Adamson PC, Gamis A, Keren R, Aplenc R. Comparison of in-patient costs for children treated on the AAML0531 clinical trial: A report from the Children's Oncology Group. Pediatric blood & cancer. 2015 Oct;62(10):1775-81. Epub 2015 May 6. PMID: 25946708
  • Chow EJ, Asselin BL, Schwartz CL, Doody DR, Leisenring WM, Aggarwal S, Baker KS, Bhatia S, Constine LS, Freyer DR, Lipshultz SE, Armenian SH. Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Aug 20;33(24):2639-45. Epub 2015 May 26. PMID: 26014292
  • Dupuis LL, Kelly KM, Krischer JP, Langevin AM, Tamura RN, Xu P, Chen L, Kolb EA, Ullrich NJ, Sahler OJZ, Hendershot E, Stratton A, Sung L, McLean TW. Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial. Cancer. 2018 Mar 15;124(6):1188-1196. Epub 2017 Dec 19. PMID: 29266260
  • Johnston DL, Nagarajan R, Caparas M, Schulte F, Cullen P, Aplenc R, Sung L. Reasons for non-completion of health related quality of life evaluations in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. PloS one. 2013 Sep 6;8(9):e74549. doi: 10.1371/journal.pone.0074549. eCollection 2013. PMID: 24040278
  • Roth ME, Unger JM, O'Mara AM, Lewis MA, Budd T, Johnson RH, Pollock BH, Blanke C, Freyer DR. Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era. Cancer medicine. 2020 Mar;9(6):2146-2152. Epub 2020 Feb 3. PMID: 32009305
  • Schulte FSM, Patton M, Alberts NM, Kunin-Batson A, Olson-Bullis BA, Forbes C, Russell KB, Neville A, Heathcote LC, Karlson CW, Racine NM, Charnock C, Hocking MC, Banerjee P, Tutelman PR, Noel M, Krull KR. Pain in long-term survivors of childhood cancer: A systematic review of the current state of knowledge and a call to action from the Children's Oncology Group. Cancer. 2021 Jan 1;127(1):35-44. Epub 2020 Oct 28. PMID: 33112416
  • Lipshultz ER, Chow EJ, Doody DR, Armenian SH, Asselin BL, Baker KS, Bhatia S, Constine LS, Freyer DR, Kopp LM, Schwartz CL, Lipshultz SE, Vrooman LM. Cardiometabolic Risk in Childhood Cancer Survivors: A Report from the Children's Oncology Group. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Mar 1;31(3):536-542. PMID: 34810210
  • Mittal N, Langevin AM, Kyono W, Dickens DS, Grimes A, Salsman JM, Pollock BH, Roth M. Barriers to Pediatric Oncologist Enrollment of Adolescents and Young Adults on a Cross-Network National Clinical Trials Network Supportive Care Cancer Clinical Trial. Journal of adolescent and young adult oncology. 2022 Feb;11(1):117-121. Epub 2021 May 13. PMID: 33983848
  • Gerbing RB, Alonzo TA, Sung L, Gamis AS, Meshinchi S, Plon SE, Bertuch AA, Gramatges MM. Shorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children's Oncology Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Nov 1;34(31):3766-3772. PMID: 27354474
  • Zerr DM, Milstone AM, Dvorak CC, Adler AL, Chen L, Villaluna D, Dang H, Qin X, Addetia A, Yu LC, Conway Keller M, Esbenshade AJ, August KJ, Fisher BT, Sung L. Chlorhexidine gluconate bathing in children with cancer or those undergoing hematopoietic stem cell transplantation: A double-blinded randomized controlled trial from the Children's Oncology Group. Cancer. 2021 Jan 1;127(1):56-66. Epub 2020 Oct 20. PMID: 33079403
  • Dupuis LL, Tamura RN, Kelly KM, Krischer JP, Langevin AM, Chen L, Kolb EA, Ullrich NJ, Sahler OJZ, Hendershot E, Stratton A, Sung L, McLean TW. Risk factors for chemotherapy-induced nausea in pediatric patients receiving highly emetogenic chemotherapy. Pediatric blood & cancer. 2019 Apr;66(4):e27584. Epub 2018 Dec 18. PMID: 30561134
  • Addetia A, Greninger AL, Adler A, Yuan S, Makhsous N, Qin X, Zerr DM. A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis. Antimicrobial agents and chemotherapy. 2019 May 24;63. (6). Print 2019 Jun. PMID: 30988144
  • Haase JE, Kintner EK, Robb SL, Stump TE, Monahan PO, Phillips C, Stegenga KA, Burns DS. The Resilience in Illness Model Part 2: Confirmatory Evaluation in Adolescents and Young Adults With Cancer. Cancer nursing. 2017 Nov-Dec;40(6):454-463. PMID: 27984241
  • Sugalski AJ, Lo T, Beauchemin M, Grimes AC, Robinson PD, Walsh AM, Santesso N, Dang H, Fisher BT, Wrightson AR, Yu LC, Sung L, Dupuis LL. Facilitators and barriers to clinical practice guideline-consistent supportive care at pediatric oncology institutions: a Children's Oncology Group study. Implementation science communications. 2021 Sep 16;2(1):106. PMID: 34530933
  • Kutny MA, Alonzo TA, Gamazon ER, Gerbing RB, Geraghty D, Lange B, Heerema NA, Sung L, Aplenc R, Franklin J, Raimondi SC, Hirsch BA, Konkashbaev A, Cox NJ, Onel K, Gamis AS, Meshinchi S. Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children's Oncology Group. Leukemia. 2015 Dec;29(12):2424-6. Epub 2015 Jul 1. PMID: 26126966
  • Ware ME, Kadan-Lottick NS, Devidas M, Terrell S, Chow EJ, Ehrhardt MJ, Hardy KK, Chemaitilly W, Hein W, Winick N, Teachey D, Esbenshade A, Armenian SH, Partin RE, Ness KK. Design and methods of a randomized web-based physical activity intervention among children with cancer: A report from the Children's Oncology Group. Contemporary clinical trials. 2022 Nov;122:106961. Epub 2022 Oct 10. PMID: 36228982
  • Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay N, Wong FL, Evans WE, Pui CH, Bhatia S, Relling MV. Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Apr 10;33(11):1235-42. Epub 2015 Jan 26. PMID: 25624441
  • Bhatia S, Armenian SH, Armstrong GT, van Dulmen-den Broeder E, Hawkins MM, Kremer LC, Kuehni CE, Olsen JH, Robison LL, Hudson MM. Collaborative Research in Childhood Cancer Survivorship: The Current Landscape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Sep 20;33(27):3055-64. Epub 2015 Aug 24. PMID: 26304891
  • Johnston D, Gerbing R, Alonzo T, Aplenc R, Nagarajan R, Schulte F, Cullen P, Sung L. Patient-Reported Outcome Coordinator Did Not Improve Quality of Life Assessment Response Rates: A Report from the Children's Oncology Group. PloS one. 2015 Apr 27;10(4):e0125290. doi: 10.1371/journal.pone.0125290. eCollection 2015. PMID: 25915772
  • Lau S, Lu X, Balsamo L, Devidas M, Winick N, Hunger SP, Carroll W, Stork L, Maloney K, Kadan-Lottick N. Family life events in the first year of acute lymphoblastic leukemia therapy: a children's oncology group report. Pediatric blood & cancer. 2014 Dec;61(12):2277-84. Epub 2014 Aug 30. PMID: 25175168
  • Landier W, Hageman L, Chen Y, Kornegay N, Evans WE, Bostrom BC, Casillas J, Dickens DS, Angiolillo AL, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 May 20;35(15):1730-1736. Epub 2017 Mar 24. PMID: 28339328
  • Schulte F, Kunin-Batson AS, Olson-Bullis BA, Banerjee P, Hocking MC, Janzen L, Kahalley LS, Wroot H, Forbes C, Krull KR. Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children's Oncology Group. Journal of cancer survivorship : research and practice. 2019 Dec;13(6):921-931. Epub 2019 Oct 17. PMID: 31625086
  • Zwaan CM, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, De Bont ES, De Moerloose B, Dworzak M, Gibson BE, Hasle H, Leverger G, Locatelli F, Ragu C, Ribeiro RC, Rizzari C, Rubnitz JE, Smith OP, Sung L, Tomizawa D, van den Heuvel-Eibrink MM, Creutzig U, Kaspers GJ. Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Sep 20;33(27):2949-62. Epub 2015 Aug 24. PMID: 26304895
  • Patel P, Robinson PD, Orsey A, Freedman JL, Langevin AM, Woods D, Sung L, Dupuis LL. Chemotherapy-Induced Nausea and Vomiting Prophylaxis: Practice Within the Children's Oncology Group. Pediatric blood & cancer. 2016 May;63(5):887-92. Epub 2016 Jan 27. PMID: 26864262
  • Hudson MM, Bhatia S, Casillas J, Landier W, SECTION ON HEMATOLOGY/ONCOLOGY CHILDREN’S ONCOLOGY GROUP AMERICAN SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY, Rogers ZR, Allen C, Harper J, Hord J, Jain J, Warwick A, Wetmore C, Yates A, Lipton J, Wilson H, Leavey P, Billett A, DiPaola J, Graham D, Hastings C, Matthews D, Pace B, Stork L, Velez MC, Wechsler D. Long-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors. Pediatrics. 2021 Sep;148. (3). PMID: 34462344
  • Bhatia S. Genetics of Anthracycline Cardiomyopathy in Cancer Survivors: JACC: CardioOncology State-of-the-Art Review. JACC. CardioOncology. 2020 Nov;2(4):539-552. Epub 2020 Dec 22. PMID: 33364618
  • Haase JE, Stegenga K, Robb SL, Hooke MC, Burns DS, Monahan PO, Stump TE, Henley AK, Haut PR, Cherven B, Roll L, Langevin AM, Pickler RH, Albritton K, Hawkins D, Osterkamp E, Mitby P, Smith J, Diaz VR, Garcia-Frausto E, Moore M. Randomized Clinical Trial of a Self-care and Communication Intervention for Parents of Adolescent/Young Adults Undergoing High-Risk Cancer Treatment: A Report From the Children's Oncology Group. Cancer nursing. 2022 Jul-Aug 1;45(4):316-331. Epub 2021 Nov 24. PMID: 34817419
  • Freyer DR, Brock P, Knight K, Reaman G, Cabral S, Robinson PD, Sung L. Interventions for cisplatin-induced hearing loss in children and adolescents with cancer. The Lancet. Child & adolescent health. 2019 Aug;3(8):578-584. Epub 2019 May 31. PMID: 31160205
  • Lindemulder SJ, Stork LC, Bostrom B, Lu X, Devidas M, Hunger S, Neglia JP, Kadan-Lottick NS. Survivors of standard risk acute lymphoblastic leukemia do not have increased risk for overweight and obesity compared to non-cancer peers: a report from the Children's Oncology Group. Pediatric blood & cancer. 2015 Jun;62(6):1035-41. Epub 2015 Feb 7. PMID: 25663378
  • Wang X, Sun CL, Hageman L, Smith K, Singh P, Desai S, Hawkins DS, Hudson MM, Mascarenhas L, Neglia JP, Oeffinger KC, Ritchey AK, Robison LL, Villaluna D, Landier W, Bhatia S. Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Nov 10;35(32):3688-3696. Epub 2017 Oct 4. PMID: 28976792
  • Orgel E, Freyer DR, Ullrich NJ, Hardy KK, Thomas SM, Dvorak CC, Esbenshade AJ. Assessment of provider perspectives on otoprotection research for children and adolescents: A Children's Oncology Group Cancer Control and Supportive Care Committee survey. Pediatric blood & cancer. 2020 Nov;67(11):e28647. Epub 2020 Sep 4. PMID: 32886425
  • Zheng DJ, Lu X, Schore RJ, Balsamo L, Devidas M, Winick NJ, Raetz EA, Loh ML, Carroll WL, Sung L, Hunger SP, Angiolillo AL, Kadan-Lottick NS. Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial. Cancer. 2018 Feb 1;124(3):571-579. Epub 2017 Nov 7. PMID: 29112230
  • Pole JD, Gibson P, Ethier MC, Lazor T, Johnston DL, Portwine C, Silva M, Alexander S, Sung L. Evaluation of treatment-related mortality among paediatric cancer deaths: a population based analysis. British journal of cancer. 2017 Feb 14;116(4):540-545. Epub 2017 Jan 17. PMID: 28095399
  • Gamis AS, Alonzo TA, Meshinchi S, Sung L, Gerbing RB, Raimondi SC, Hirsch BA, Kahwash SB, Heerema-McKenney A, Winter L, Glick K, Davies SM, Byron P, Smith FO, Aplenc R. Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children’s Oncology Group trial AAML0531. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2014 Sep 20;32(27):3021-32. PMID: 25092781
  • Fisher BT, Zaoutis T, Dvorak CC, Nieder M, Zerr D, Wingard JR, Callahan C, Villaluna D, Chen L, Dang H, Esbenshade AJ, Alexander S, Wiley JM, Sung L. Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial. JAMA. 2019 Nov 5;322(17):1673-1681. PMID: 31688884
  • Salzer WL, Jones TL, Devidas M, Dreyer ZE, Gore L, Winick NJ, Sung L, Raetz E, Loh ML, Wang CY, De Lorenzo P, Valsecchi MG, Pieters R, Carroll WL, Hunger SP, Hilden JM, Brown P. Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: a report from the Children's Oncology Group. Pediatric blood & cancer. 2015 Mar;62(3):414-8. Epub 2014 Nov 18. PMID: 25407157
  • Frederick NN, Klosky JL, Meacham LR, Quinn GP, Kelvin JF, Cherven B, Freyer DR, Dvorak CC, Brackett J, Ahmed-Winston S, Bryson E, Chow EJ, Levine J. Infrastructure of Fertility Preservation Services for Pediatric Cancer Patients: A Report From the Children's Oncology Group. JCO oncology practice. 2022 Mar;18(3):e325-e333. Epub 2021 Oct 28. PMID: 34709943
  • Chow EJ, Aplenc R, Vrooman LM, Doody DR, Huang YV, Aggarwal S, Armenian SH, Baker KS, Bhatia S, Constine LS, Freyer DR, Kopp LM, Leisenring WM, Asselin BL, Schwartz CL, Lipshultz SE. Late health outcomes after dexrazoxane treatment: A report from the Children's Oncology Group. Cancer. 2022 Feb 15;128(4):788-796. Epub 2021 Oct 13. PMID: 34644414
  • Seelisch J, Sung L, Kelly MJ, Raybin JL, Beauchemin M, Dvorak CC, Kelly KP, Nieder ML, Noll RB, Thackray J, Ullrich NJ, Cabral S, Dupuis LL, Robinson PD. Identifying clinical practice guidelines for the supportive care of children with cancer: A report from the Children's Oncology Group. Pediatric blood & cancer. 2019 Jan;66(1):e27471. Epub 2018 Sep 26. PMID: 30259647
  • Hoppmann AL, Chen Y, Landier W, Hageman L, Evans WE, Wong FL, Relling MV, Bhatia S. Individual prediction of nonadherence to oral mercaptopurine in children with acute lymphoblastic leukemia: Results from COG AALL03N1. Cancer. 2021 Oct 15;127(20):3832-3839. Epub 2021 Jun 23. PMID: 34161608
  • Dickens DS, Roth ME, Pollock BH, Langevin AM. Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs. JCO oncology practice. 2020 Oct;16(10):e1060-e1066. Epub 2020 May 12. PMID: 32396490
  • Stark D, Rosenberg AR, Johnston D, Knight K, Caperon L, Uleryk E, Frazier AL, Sung L. Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review. Journal of speech, language, and hearing research : JSLHR. 2016 Oct 1;59(5):1247-1252. PMID: 27603148
  • Thompson P, Wheeler HE, Delaney SM, Lorier R, Broeckel U, Devidas M, Reaman GH, Scorsone K, Sung L, Dolan ME, Berg SL. Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group. Cancer chemotherapy and pharmacology. 2014 Oct;74(4):831-8. Epub 2014 Aug 14. PMID: 25119182
  • Miller TP, Li Y, Kavcic M, Troxel AB, Huang YS, Sung L, Alonzo TA, Gerbing R, Hall M, Daves MH, Horton TM, Pulsipher MA, Pollard JA, Bagatell R, Seif AE, Fisher BT, Luger S, Gamis AS, Adamson PC, Aplenc R. Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 May 1;34(13):1537-43. Epub 2016 Feb 16. PMID: 26884558
  • Meeske KA, Ji L, Freyer DR, Gaynon P, Ruccione K, Butturini A, Avramis VI, Siegel S, Matloub Y, Seibel NL, Sposto R. Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. Pediatric blood & cancer. 2015 Dec;62(12):2140-9. Epub 2015 Jul 14. PMID: 26173904
  • Miller TP, Getz KD, Kavcic M, Li Y, Huang YS, Sung L, Alonzo TA, Gerbing R, Daves M, Horton TM, Pulsipher MA, Pollard J, Bagatell R, Seif AE, Fisher BT, Gamis AS, Aplenc R. A comparison of discharge strategies after chemotherapy completion in pediatric patients with acute myeloid leukemia: a report from the Children's Oncology Group. Leukemia & lymphoma. 2016 Jul;57(7):1567-74. Epub 2016 Jan 4. PMID: 26727639
  • Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program. Journal of oncology practice. 2016 Apr;12(4):e388-95. Epub 2016 Mar 29. PMID: 27026648
  • Fisher BT, Westling T, Boge CLK, Zaoutis TE, Dvorak CC, Nieder M, Zerr DM, Wingard JR, Villaluna D, Esbenshade AJ, Alexander S, Gunn S, Wheat LJ, Sung L. Prospective Evaluation of Galactomannan and (1→3) β-d-Glucan Assays as Diagnostic Tools for Invasive Fungal Disease in Children, Adolescents, and Young Adults With Acute Myeloid Leukemia Receiving Fungal Prophylaxis. Journal of the Pediatric Infectious Diseases Society. 2021 Sep 23;10(8):864-871. PMID: 34173659
  • Landier W, Skinner R, Wallace WH, Hjorth L, Mulder RL, Wong FL, Yasui Y, Bhakta N, Constine LS, Bhatia S, Kremer LC, Hudson MM. Surveillance for Late Effects in Childhood Cancer Survivors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Jul 20;36(21):2216-2222. Epub 2018 Jun 6. PMID: 29874139
  • Christen S, Roser K, Mulder RL, Ilic A, Lie HC, Loonen JJ, Mellblom AV, Kremer LCM, Hudson MM, Constine LS, Skinner R, Scheinemann K, Gilleland Marchak J, Michel G, IGHG psychological late effects group. Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Journal of cancer survivorship : research and practice. 2020 Dec;14(6):923-938. Epub 2020 Aug 25. PMID: 32839902
  • Landier W, Chen Y, Hageman L, Kim H, Bostrom BC, Casillas JN, Dickens DS, Evans WE, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Comparison of self-report and electronic monitoring of 6MP intake in childhood ALL: a Children's Oncology Group study. Blood. 2017 Apr 6;129(14):1919-1926. Epub 2017 Feb 2. PMID: 28153823
  • Frederick NN, Bingen K, Bober SL, Cherven B, Xu X, Quinn GP, Ji L, Freyer DR. Pediatric oncology clinician communication about sexual health with adolescents and young adults: A report from the children's oncology group. Cancer medicine. 2021 Aug;10(15):5110-5119. Epub 2021 Jun 15. PMID: 34128352
  • Otto WR, Dvorak CC, Boge CLK, Ostrosky-Zeichner L, Esbenshade AJ, Nieder ML, Alexander S, Steinbach WJ, Dang H, Villaluna D, Chen L, Skeens M, Zaoutis TE, Sung L, Fisher BT. Prospective Evaluation of the Fungitell® (1→3) Beta-D-Glucan Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A Report from the Children's Oncology Group. Pediatric transplantation. 2023 Feb;27(1):e14399. Epub 2022 Oct 26. PMID: 36299233
  • King AA, Vesely SK, Elwood J, Basso J, Carson K, Sung L. The American Society of Hematology Clinical Research Training Institute is associated with high retention in academic hematology. Blood. 2016 Dec 22;128(25):2881-2885. Epub 2016 Oct 26. PMID: 27784672
  • Sung L, Aplenc R, Alonzo TA, Gerbing RB, Wang YC, Meshinchi S, Gamis AS. Association between prolonged neutropenia and reduced relapse risk in pediatric AML: A report from the children's oncology group. International journal of cancer. 2016 Nov 1;139(9):1930-5. Epub 2016 Jul 4. PMID: 27312107
  • Viola A, Balsamo L, Neglia JP, Brouwers P, Ma X, Kadan-Lottick NS. The Behavior Rating Inventory of Executive Function (BRIEF) to Identify Pediatric Acute Lymphoblastic Leukemia (ALL) Survivors At Risk for Neurocognitive Impairment. Journal of pediatric hematology/oncology. 2017 Apr;39(3):174-178. PMID: 28085741
  • Hendricks-Ferguson VL, Barnes YJ, Cherven B, Stegenga K, Roll L, Docherty SL, Haase JE. Stories and Music for Adolescent/Young Adult Resilience During Transplant Partnerships: Strategies to Support Academic-Clinical Nurse Collaborations in Behavioral Intervention Studies. Clinical nurse specialist CNS. 2017 Jul-Aug;31(4):195-200. PMID: 28594670
  • Phillips CA, Pollock BH. Big Data for Nutrition Research in Pediatric Oncology: Current State and Framework for Advancement. Journal of the National Cancer Institute. Monographs. 2019 Sep 1;2019(54):127-131. PMID: 31532530
  • van Dorp W, Mulder RL, Kremer LC, Hudson MM, van den Heuvel-Eibrink MM, van den Berg MH, Levine JM, van Dulmen-den Broeder E, di Iorgi N, Albanese A, Armenian SH, Bhatia S, Constine LS, Corrias A, Deans R, Dirksen U, Gracia CR, Hjorth L, Kroon L, Lambalk CB, Landier W, Levitt G, Leiper A, Meacham L, Mussa A, Neggers SJ, Oeffinger KC, Revelli A, van Santen HM, Skinner R, Toogood A, Wallace WH, Haupt R. Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Oct 1;34(28):3440-50. Epub 2016 Jul 25. PMID: 27458300
  • Siembida EJ, Loomans-Kropp HA, Tami-Maury I, Freyer DR, Sung L, Crosswell HE, Pollock BH, Roth ME. Comparing Barriers and Facilitators to Adolescent and Young Adult Clinical Trial Enrollment Across High- and Low-Enrolling Community-Based Clinics. The oncologist. 2022 May 6;27(5):363-370. PMID: 35522559
  • Santesso N, Beauchemin M, Robinson PD, Walsh AM, Sugalski AJ, Lo T, Dang H, Fisher BT, Grimes AC, Wrightson AR, Yu LC, Sung L, Dupuis LL. Clinical practice guideline recommendation summaries for pediatric oncology health care professionals: A qualitative study. PloS one. 2023 Feb 21;18(2):e0281890. doi: 10.1371/journal.pone.0281890. eCollection 2023. PMID: 36809380
  • Chung J, Negm L, Bianchi V, Stengs L, Das A, Liu ZA, Sudhaman S, Aronson M, Brunga L, Edwards M, Forster V, Komosa M, Davidson S, Lees J, Tomboc P, Samuel D, Farah R, Bendel A, Knipstein J, Schneider KW, Reschke A, Zelcer S, Zorzi A, McWilliams R, Foulkes WD, Bedgood R, Peterson L, Rhode S, Van Damme A, Scheers I, Gardner S, Robbins G, Vanan MI, Meyn MS, Auer R, Leach B, Burke C, Villani A, Malkin D, Bouffet E, Huang A, Taylor MD, Durno C, Shlien A, Hawkins C, Getz G, Maruvka YE, Tabori U, International Replication Repair Deficiency Consortium. Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Feb 1;41(4):766-777. Epub 2022 Oct 14. PMID: 36240479
  • Wang X, Sun CL, Quiñones-Lombraña A, Singh P, Landier W, Hageman L, Mather M, Rotter JI, Taylor KD, Chen YD, Armenian SH, Winick N, Ginsberg JP, Neglia JP, Oeffinger KC, Castellino SM, Dreyer ZE, Hudson MM, Robison LL, Blanco JG, Bhatia S. CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Mar 10;34(8):863-70. Epub 2016 Jan 25. PMID: 26811534
  • Chow EJ, Anderson L, Baker KS, Bhatia S, Guilcher GM, Huang JT, Pelletier W, Perkins JL, Rivard LS, Schechter T, Shah AJ, Wilson KD, Wong K, Grewal SS, Armenian SH, Meacham LR, Mulrooney DA, Castellino SM. Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 May;22(5):782-95. Epub 2016 Jan 21. PMID: 26802323
  • Bass JK, Knight KR, Yock TI, Chang KW, Cipkala D, Grewal SS. Evaluation and Management of Hearing Loss in Survivors of Childhood and Adolescent Cancers: A Report From the Children's Oncology Group. Pediatric blood & cancer. 2016 Jul;63(7):1152-62. Epub 2016 Feb 29. PMID: 26928933
  • Mitchell HR, Lu X, Myers RM, Sung L, Balsamo LM, Carroll WL, Raetz E, Loh ML, Mattano LA Jr, Winick NJ, Devidas M, Hunger SP, Maloney K, Kadan-Lottick NS. Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331. International journal of cancer. 2016 Jan 15;138(2):332-9. Epub 2015 Sep 3. PMID: 26235006
  • Frederick NN, Klosky JL, Meacham L, Quinn GP, Kelvin JF, Cherven B, Freyer DR, Dvorak CC, Brackett J, Ahmed-Winston S, Bryson E, Su HI, Chow EJ, Levine J. Fertility Preservation Practices at Pediatric Oncology Institutions in the United States: A Report From the Children's Oncology Group. JCO oncology practice. 2023 Apr;19(4):e550-e558. Epub 2023 Feb 10. PMID: 36763922
  • Treister N, Nieder M, Baggott C, Olson E, Chen L, Dang H, Krailo M, August A, Sung L. Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation. British journal of cancer. 2017 Jan 3;116(1):21-27. Epub 2016 Nov 22. PMID: 27875526
  • Dupuis LL, Lu X, Mitchell HR, Sung L, Devidas M, Mattano LA Jr, Carroll WL, Winick N, Hunger SP, Maloney KW, Kadan-Lottick NS. Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group. Cancer. 2016 Apr 1;122(7):1116-25. Epub 2016 Jan 15. PMID: 26773735
  • Berkman AM, Murphy KM, Siembida EJ, Lau N, Geng Y, Parsons SK, Salsman JM, Roth ME. Inclusion of Patient-Reported Outcomes in Adolescent and Young Adult Phase III Therapeutic Trials: An Analysis of Cancer Clinical Trials Registered on ClinicalTrials.gov. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2021 Dec;24(12):1820-1827. Epub 2021 Aug 8. PMID: 34838280
  • Haugen M, Kelly KP, Leonard M, Mills D, Sung L, Mowbray C, Landier W. Nurse-Led Programs to Facilitate Enrollment to Children's Oncology Group Cancer Control Trials. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. 2016 Sep;33(5):387-91. Epub 2015 Nov 26. PMID: 26611754
  • Nagarajan R, Gerbing R, Alonzo T, Johnston DL, Aplenc R, Kolb EA, Meshinchi S, Barakat LP, Sung L. Quality of life in pediatric acute myeloid leukemia: Report from the Children's Oncology Group. Cancer medicine. 2019 Aug;8(9):4454-4464. Epub 2019 Jun 12. PMID: 31190442
  • Alexander S, Fisher BT, Gaur AH, Dvorak CC, Villa Luna D, Dang H, Chen L, Green M, Nieder ML, Fisher B, Bailey LC, Wiernikowski J, Sung L, Children’s Oncology Group. Effect of Levofloxacin Prophylaxis on Bacteremia in Children With Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial. JAMA. 2018 Sep 11;320(10):995-1004. PMID: 30208456
  • Johnston DL, Sung L, Stark D, Frazier AL, Rosenberg AR. A systematic review of patient-reported outcome measures of neuropathy in children, adolescents and young adults. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2016 Sep;24(9):3723-8. Epub 2016 Apr 1. PMID: 27037813
  • Effinger KE, Haardörfer R, Marchak JG, Escoffery C, Landier W, Kommajosula A, Hendershot E, Sadak KT, Eshelman-Kent D, Kinahan K, Freyer DR, Chow EJ, Mertens AC. Current pediatric cancer survivorship practices: a report from the Children's Oncology Group. Journal of cancer survivorship : research and practice. 2022 Jan 31: 1-10. Epub 2022 Jan 31. PMID: 35098485
  • Kelly KP, Wells DK, Chen L, Reeves E, Mass E, Camitta B, Hinds PS. Caregiving demands and well-being in parents of children treated with outpatient or inpatient methotrexate infusion: a report from the children's oncology group. Journal of pediatric hematology/oncology. 2014 Aug;36(6):495-500. PMID: 23588342
  • Kunin-Batson AS, Lu X, Balsamo L, Graber K, Devidas M, Hunger SP, Carroll WL, Winick NJ, Mattano LA Jr, Maloney KW, Kadan-Lottick NS. Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer. 2016 May 15;122(10):1608-17. Epub 2016 Mar 29. PMID: 27028090
  • Orgel E, Villaluna D, Krailo MD, Esbenshade A, Sung L, Freyer DR. Sodium thiosulfate for prevention of cisplatin-induced hearing loss: updated survival from ACCL0431. The Lancet. Oncology. 2022 May;23(5):570-572. PMID: 35489339
  • Whitlow PG, Caparas M, Cullen P, Trask C, Schulte F, Embry L, Nagarajan R, Johnston DL, Sung L. Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children's Oncology Group. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2015 Jun;24(6):1297-301. Epub 2014 Nov 29. PMID: 25429821
  • Wadhwa A, Chen Y, Hageman L, Hoppmann AL, Angiolillo A, Dickens DS, Lew G, Neglia JP, Ravindranath Y, Ritchey AK, Termuhlen A, Wong FL, Landier W, Bhatia S. Body mass index during maintenance therapy and relapse risk in children with acute lymphoblastic leukemia: A Children's Oncology Group report. Cancer. 2023 Jan 1;129(1):151-160. Epub 2022 Nov 12. PMID: 36369905
  • Rodwin RL, Kairalla JA, Hibbitts E, Devidas M, Whitley MK, Mohrmann CE, Schore RJ, Raetz E, Winick NJ, Hunger SP, Loh ML, Hockenberry MJ, Angiolillo AL, Ness KK, Kadan-Lottick NS. Persistence of Chemotherapy-Induced Peripheral Neuropathy Despite Vincristine Reduction in Childhood B-Acute Lymphoblastic Leukemia. Journal of the National Cancer Institute. 2022 Aug 8;114(8):1167-1175. PMID: 35552709
  • Hardy KK, Kairalla JA, Gioia AR, Weisman HS, Gurung M, Noll RB, Hinds PS, Hibbitts E, Salzer WL, Burke MJ, Winick NJ, Embry L. Impaired neurocognitive functioning 3 months following diagnosis of high-risk acute lymphoblastic leukemia: A report from the Children's Oncology Group. Pediatric blood & cancer. 2023 Jul;70(7):e30350. Epub 2023 May 2. PMID: 37129114

Clinical Trials

Study Name Clinical Trial ID
Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors NCT03206450
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies NCT00736749
Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors NCT02717507
Cancer Care Delivery in Adolescent and Young Adult Patients With Acute Lymphoblastic Leukemia NCT03204916
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma NCT03057626
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission NCT01503632
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant NCT03057054
Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant NCT01503515
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia NCT01307579
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas NCT01793233
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment NCT01790152
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors NCT00082745
Neuropsychological and Behavioral Testing in Younger Patients With Cancer NCT00772200
Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant NCT01817075
Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer NCT03223753
Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer NCT05228275
Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy NCT01503086
Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric Oncology NCT02847130
A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients NCT05711667
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia NCT05702645
Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States NCT04928599
Levocarnitine To Protect the Liver From Chemotherapy for Leukemia or Lymphoma NCT05602194
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study NCT04089358
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma NCT05705531