Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Sponsor
Children's Oncology Group
Status
Not yet recruiting
NCT ID
NCT07022678
This phase III trial compares the effect xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML). Xylitol is a naturally occurring sugar compound found in fruits and vegetables. Xylitol has been shown to limit the growth of bacteria in the mouth, and to reduce cavities, plaque on the teeth, and inflammation of the gums. Treatment for AML includes chemotherapy. Patients receiving chemotherapy for AML have a risk of developing bloodstream infections. Bloodstream infections can make patients very sick, can contribute to delays in treatment, and can even cause death. In AML patients, bacteria or fungus (yeast) can sometimes enter the bloodstream from the mouth. Using xylitol dental wipes may help to reduce bloodstream infections in children being treated for AML.
Intervention
Best Practice, Biospecimen Collection, Cytarabine, Electronic Health Record Review, Placebo Administration, Xylitol-containing Oral Wipe
Condition
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Investigators
Jennifer J Wilkes
CT Research Area
Symptom Science