Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors

This clinical trial studies cancer survivors to identify those who are at increased risk of
developing late-occurring complications after undergoing treatment for childhood cancer. A
patient's genes may affect the risk of developing complications, such as congestive heart
failure, avascular necrosis, stroke, and second cancer, years after undergoing cancer
treatment. Genetic studies may help doctors identify survivors of childhood cancer who are
more likely to develop late complications.

Intervention

Laboratory Biomarker Analysis, Questionnaire Administration

Condition

Childhood Malignant Neoplasm

Investigators

Smita Bhatia, Vlad C. Radulescu, Vonda L. Crouse, Nichole L. Bryant, Nicholas W. McGregor, Eric J. Lowe, Doured Daghistani, Paul D. Harker-Murray, ZoAnn E. Dreyer, Michael K. Richards, Yvan Samson, Fataneh (Fae) Majlessipour, Ashok B. Raj, Alissa Kahn, Christopher Mpofu, Rajaram Nagarajan, Mariko Sato, Gail C. Megason, Emad K. Salman, Lolie C. Yu, Stuart L. Cramer, Tanya R. Brown, Nibal A. Zaghloul, Thomas W. McLean, Denise A. Rokitka, Nadine P. SantaCruz, William A. May, Sandeep Batra, Joseph P. Neglia, Mariana P. Silva, Adonis N. Lorenzana, Danielle N. Friedman, Samuel O. Anim, Ramamoorthy Nagasubramanian, Arthur K. Ritchey, Stanton C. Goldman, Robert J. Hayashi, Jessica L. Heath, Jordan R. Hansford, Maria L. Kirby, Wade T. Kyono, Marianne B. Phillips, Catherine A. Long, Lillian R. Meacham, Kenneth B. De Santes, Rene Y. McNall-Knapp, Mark A. Ranalli, Jay Michael S. Balagtas, Mark E. Weinblatt, Helen Irving, Dana A. Obzut, Felipe S. Bautista-Otanez, Uma H. Athale, Michael S. Isakoff, Mandy M. Atkinson, Ayman A. El-Sheikh, Nkechi I. Mba, Leo Mascarenhas, Kathleen J. Yost, Carola A. Arndt, Philip M. Monteleone, David L. Becton, Michael B. Harris, Debra L. Friedman, Donna L. Johnston, Patrick J. Leavey, Jaime M. Libes, Saro H. Armenian, William D. Roberts, Eugenia Chang, Paul C. Nathan, Conrad V. Fernandez, Jeffrey S. Dome, Janice F. Olson, Shayna M. Zelcer, Rebecca E. McFall, Keith J. August, Judy L. Felgenhauer, Bassem I. Razzouk, Lars M. Wagner, Carla B. Golden, Sarah J. McKillop, Rama Jasty, Nina S. Kadan-Lottick, Laura A. Campbell, Colleen H. McDonough, Mary L. Schmidt, Melissa M. Hudson, Alan K. Ikeda

See list of participating sites