Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission

This randomized phase III trial studies compliance to a mercaptopurine treatment intervention compared to standard of care in younger patients with acute lymphoblastic leukemia in remission. Assessing ways to help patients who have acute lymphoblastic leukemia to take their medications as prescribed may help them in taking their medications more consistently and may improve treatment outcomes.

Intervention

behavioral intervention, mercaptopurine, standard follow-up care, compliance monitoring, questionnaire administration, laboratory biomarker analysis

Condition

Childhood Acute Lymphoblastic Leukemia in Remission

Investigators

Smita Bhatia, MD, MPH, Rama Jasty, Sharon M. Castellino, Maxine L. Hetherington, Carola A. Arndt, Leo Mascarenhas, Mandy M. Atkinson, Alyssa T. Reddy, Janice F. Olson, Mehmet F. Ozkaynak, Iftikhar Hanif, Emmett H. Broxson, Yousif (Joe) H. Matloub, Jeffrey W. Taub, Gregory A. Hale, Jonathan Bernstein, Alice Lee, Mary L. Schmidt, Robert M. Cooper, Minnie Abromowitch, Brenda J. Weigel, Anne-Marie R. Langevin, Bruce C. Bostrom, Ronnie W. Neuberg, Linda Granowetter, Robert W. Wilkinson, Judy L. Felgenhauer, Douglas S. Hawkins, William B. Slayton, Neyssa M. Marina, Cameron K. Tebbi, Jong-Hyo Kwon, Peter D. Cole, Susan G. Kreissman, William D. Roberts, M. C. Johnson, Smita Bhatia, Koh B. Boayue, Wendy L. Woods-Swafford, Naomi J. Winick, Narayana Gowda, Jeffrey S. Dome, Pamela H. Kempert, Jeffrey H. Schwartz, Steven L. Halpern, Jaime Estrada, Robert J. Fallon, Marla H. Daves, Susumu Inoue, Amanda M. Termuhlen, Sharon K. Lockhart, Bassem I. Razzouk, Steven J. Kuerbitz, David S. Dickens, Emad K. Salman, Peter H. Shaw, Christopher N. Frantz, Peter F. Coccia, Hardeo K. Panchoosingh, Michael S. Isakoff, Ayman A. El-Sheikh, Nobuko Hijiya, Rene Y. McNall-Knapp, Craig Lotterman, Burton E. Appel, Bethany G. Sleckman, Mark A. Ranalli, Gail C. Megason, Eric S. Sandler, Ramamoorthy Nagasubramanian, Douglas J. Scothorn

See list of participating sites