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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Rogers, Laura Q

University Of Alabama At Birmingham
United States

Role of gut microbe composition in psychosocial symptom response to exercise training in breast cancer survivors 5R01CA235598-06 Gabriela Riscuta, M.D., CNS
Ross, Stephen

New York University School Of Medicine
United States

Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress 5R01CA268521-04 Rachel Altshuler, Ph.D.
Russell, John A

University Of Wisconsin-Madison
United States

Treatment of Functional Deficits IN tongue muscles induced by radiation and chemoradiation treatment 5R37CA225608-07 Cecilia Lee, Dr.P.H., RN
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.
Santomasso, Bianca Denise

Sloan-Kettering Inst Can Research
United States

Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy 5R01CA293922-02 Monica Epstein, B.S.N., RN, OCN
Schaverien, Mark V

University Of Tx Md Anderson Can Ctr
United States

Lymphedema Prevention Through Immediate Lymphatic Reconstruction 5R01CA292908-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Sedrak, Mina S

University Of California Los Angeles
United States

Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline 5R01CA280088-03 Goli Samimi, Ph.D., M.P.H.
Shelby, Rebecca A

Duke University
United States

Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention 1R21CA301298-01 Goli Samimi, Ph.D., M.P.H.
Shelby, Rebecca A

Duke University
United States

Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis 5R01CA249959-05 Brennan Streck, Ph.D., RN, M.P.H.
Shiozawa, Yusuke

Wake Forest University Health Sciences
United States

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy 1R21CA297068-01 Rachel Altshuler, Ph.D.
Siskind, Leah J

University Of Louisville
United States

Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease 1R01CA305985-01 Marjorie Perloff, M.D.
Smith, Ellen Mary Lavoie

University Of Alabama At Birmingham
United States

Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study 5R01CA235726-07 Brennan Streck, Ph.D., RN, M.P.H.
Sohl, Stephanie Jean

Wake Forest University Health Sciences
United States

REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE) 5R01CA266995-04 Goli Samimi, Ph.D., M.P.H.
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Status
Title Sort descending Intervention Sponsor Status
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients Megestrol Acetate, Olanzapine, Questionnaire Administration Alliance for Clinical Trials in Oncology Recruiting
Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer Fulvestrant, Letrozole, Palbociclib, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment Enhanced Usual Care, Pathways Laurie McLouth Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer Endocrine therapy interruption ETOP IBCSG Partners Foundation Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors Entecavir, Tenofovir Disoproxil Fumarate, Best Practice, Tenofovir Alafenamide SWOG Cancer Research Network Active, not recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention Alliance for Clinical Trials in Oncology Recruiting
Relaxation for Women With Breast Cancer Undergoing Radiotherapy Questionnaires, Relaxation Program, Saliva Testing M.D. Anderson Cancer Center Active, not recruiting
Reproductive Health Program in Patients With Cancer Standard practice related to reproductive heath, Training modules, algorithm, referral development ECOG-ACRIN Cancer Research Group Active, not recruiting
REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors Educational Materials, REVITALIZE Intervention Dana-Farber Cancer Institute Recruiting