Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
SWOG Cancer Research Network
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT03418961
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Intervention
Carvedilol, Laboratory Biomarker Analysis, Patient Observation
Condition
Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
Investigators
Justin Floyd, Ashkan Bahrani, Shelly S. Lo, Bryan A. Faller, Erin F. Cobain, Sunitha Vemulapalli, Jay W. Carlson, Cynthia M. Vakhariya, Kathleen J. Yost, Sailendra Vasireddy, Sung Ho B. Lee, Richard L. Deming, Barbara S. Craft, Halle C. Moore, David M. King, Hadeel Assad, Joanne E. Mortimer, Gregory A. Masters, Martine Extermann, Abdul Hai Mansoor, Anne P. O'Dea, Charles H. Nash, John M. Schallenkamp, Gina G. Chung, Thomas E. Lad, Jacklyn M. Nemunaitis, Naveed A. Rana, Bonni L. Guerin, Rachel L. Yung, Lisa Bailey, Josh D. Simmons, Yadyra Rivera, Kathryn M. Leininger, Ki Y. Chung, Charles W. Drescher, Priya Jayachandran, Alison E. Spellman, Marshall P. Stagg, Tareq Al Baghdadi, Haythem Y. Ali, Dan Costin, Bahar Moftakhar, Mahmoud Charif, Alexandra d. Zimmer, Monali K. Vasekar, Joyson Poulose, Vlad G. Zaha, Robert M. Kyler, Victor T. Lin, Site Public Contact, Keun Seok Lee, Amelia B. Zelnak, Andrew Piper-Vallillo, Iftekhar A. Khan, Shahzad Siddique, Kevin M. Kalinsky, Danish Safi