Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name Sort descending	PI Organization	Title	Grant Number	Program Official
Perez-Lougee, Giselle Katiria	Massachusetts General Hospital United States	Thriving Beyond Treatment: A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship	1R37CA303094-01	Marjorie Perloff, M.D.
Pfleger, Cathie M	Icahn School Of Medicine At Mount Sinai United States	A Drosophila model for Aromatase Inhibitor-induced Musculoskeletal Pain	1R21CA303409-01	Rachel Altshuler, Ph.D.
Phillips, Nicholas S	St. Jude Children'S Research Hospital United States	Cardiopulmonary function and cerebral blood flow in Hodgkin Lymphoma survivors	5R21CA280230-02	Eileen Dimond, R.N., M.S.
Pistilli, Emidio Edward	West Virginia University United States	Targeting Muscle Fatigability During Cachexia	5R01AR079445-04	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Plas, Ellen Van Der	Arkansas Children'S Hospital Res Inst United States	Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia	5R37CA266135-04	Asad Umar, D.V.M., Ph.D.
Pozdeyev, Nikita	University Of Colorado Denver United States	Genetic architecture of thyroid cancer and its clinical utility	5R21CA282380-02	Wendy Wang, Ph.D., M.Sc.
Prigerson, Holly Gwen	Weill Medical Coll Of Cornell Univ United States	Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)	5R35CA197730-11	Brennan Streck, Ph.D., RN, M.P.H.
Pyter, Leah M	Ohio State University United States	Chemotherapy-induced circadian master clock disruptions and fatigue	3R01CA270372-03S1	Marjorie Perloff, M.D.
Reb, Anne	Beckman Research Institute/City Of Hope United States	A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer	1R21CA293326-01	Brennan Streck, Ph.D., RN, M.P.H.
Rini, Christine	Northwestern University At Chicago United States	Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients	5R01CA292116-02	Brennan Streck, Ph.D., RN, M.P.H.
Rini, Christine	Northwestern University At Chicago United States	Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial	5R01CA271220-04	Brennan Streck, Ph.D., RN, M.P.H.
Rogers, Laura Q	University Of Alabama At Birmingham United States	Role of gut microbe composition in psychosocial symptom response to exercise training in breast cancer survivors	5R01CA235598-06	Gabriela Riscuta, M.D., CNS
Ross, Stephen	New York University School Of Medicine United States	Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress	5R01CA268521-04	Rachel Altshuler, Ph.D.
Salvemini, Daniela	Saint Louis University United States	Fingolimod and Ozanimod for the treatment and prevention of chemobrain	5R01CA261979-04	Rachel Altshuler, Ph.D.
Sands, Stephen Alan	Sloan-Kettering Inst Can Research United States	Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)	5R01CA283045-02	Marjorie Perloff, M.D.

Clinical Trials

Title Sort descending	Intervention	Sponsor	Status
Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study	Best Practice, Biospecimen Collection, Endocrine Drug Therapy, Health Education, Questionnaire Administration, Symptom Specific Assessment Tool	SWOG Cancer Research Network	Active, not recruiting
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting