Principal Investigator

Holly Gwen
Prigerson
Awardee Organization

Weill Medical Coll Of Cornell Univ
United States

Fiscal Year
2023
Activity Code
R35
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)

Despite great strides that have been made in the understanding and treatment of cancer, the number of cancer deaths remains on the rise and cancer remains the 2nd leading cause of death in the United States (US). Not only is the number of people dying of cancer increasing, but the quality of those deaths is alarmingly poor. End-of-life (EoL) care in the US has been deemed a public health crisis by the National Academy of Medicine -- a conclusion bolstered by disturbing findings from my group. My research has shown that end-stage cancer patients receive chemotherapy troublingly close to death, that end-stage cancer patients are shockingly uninformed of their prognosis and the harms of EoL treatments, that racial/ethnic minority groups receive dramatically inferior EoL cancer care, and that severe emotional pain and suffering remain largely unchecked. The current Outstanding Investigator Award (OIA) research has identified and targeted psychosocial factors to address these problems; the results have proved paradigm-shifting and practice-changing. For example, we showed that: 1) “palliative chemotherapy” does not “palliate” and may actually do more harm than good -> highlighting the need for oncologists to recognize the harms of “overtreatment” and refrain from prescribing chemotherapy to patients they deem close to death; 2) oncologist prognostic communication can improve patient prognostic understanding and lead to more informed, value-concordant EoL care, but it occurs infrequently, and ineffectively –> our Oncolo-GIST approach as a simple, effective way oncologists can feel comfortable communicating the gist of a patient’s prognosis; 3) that “one size does not fit all” in addressing disparities in EoL cancer care->our Divine Intervention targeting black patients’ medical mistrust and spiritual care needs as a way to promote advance care planning (ACP); 4) that psychosocial distress is an important influence on, as much as outcome of, EoL decision-making->our EMPOWER psychosocial intervention targeting “experiential avoidance” to promote caregiver psychosocial adjustment and engagement in ACP. Going forward, this OIA will focus on: 1) oncologist communication; 2) cancer disparities; and 3) psychosocial distress. I will leverage data, theories,and the clinical and scholarly resources (colleagues and collaborators) developed under the auspices of the current OIA to: improve oncologist delivery of high quality EoL cancer care; increase the frequency and effectiveness of their prognostic disclosures; promote cancer patients’ prognostic understanding; ensure the equitable delivery of EoL cancer care; and reduce psychosocial distress of patients and caregivers to enhance their mental health and promote their engagement in ACP. Renewal of this OIA will enable me to conduct research helping to ensure that dying cancer patients and their caregivers receive the highest quality of EoL cancer care possible.

Publications

  • Trevino KM, Martin P, Prigerson HG. Evaluating Quality Metrics for the Care of Patients With Blood Cancer Who Are Near Death. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Sep 10;34(26):3117-8. Epub 2016 Jul 25. PMID: 27458306
  • Diamond EL, Panageas KS, Dallara A, Pollock A, Applebaum AJ, Carver AC, Pentsova E, DeAngelis LM, Prigerson HG. Frequency and Predictors of Acute Hospitalization Before Death in Patients With Glioblastoma. Journal of pain and symptom management. 2017 Feb;53(2):257-264. Epub 2016 Nov 1. PMID: 27810565
  • Nissen KG, Trevino K, Lange T, Prigerson HG. Family Relationships and Psychosocial Dysfunction Among Family Caregivers of Patients With Advanced Cancer. Journal of pain and symptom management. 2016 Dec;52(6):841-849.e1. Epub 2016 Aug 9. PMID: 27521285
  • Wright JD, Chen L, Hou JY, Burke WM, Tergas AI, Ananth CV, Neugut AI, Hershman DL. Association of Hospital Volume and Quality of Care With Survival for Ovarian Cancer. Obstetrics and gynecology. 2017 Sep;130(3):545-553. PMID: 28796677
  • Prigerson HG, Bao Y, Shah MA, Paulk ME, LeBlanc TW, Schneider BJ, Garrido MM, Reid MC, Berlin DA, Adelson KB, Neugut AI, Maciejewski PK. Chemotherapy Use, Performance Status, and Quality of Life at the End of Life. JAMA oncology. 2015 Sep;1(6):778-84. PMID: 26203912
  • Lambden JP, Chamberlin P, Kozlov E, Lief L, Berlin DA, Pelissier LA, Yushuvayev E, Pan CX, Prigerson HG. Association of Perceived Futile or Potentially Inappropriate Care With Burnout and Thoughts of Quitting Among Health-Care Providers. The American journal of hospice & palliative care. 2019 Mar;36(3):200-206. Epub 2018 Aug 5. PMID: 30079753
  • Derry HM, Epstein AS, Lichtenthal WG, Prigerson HG. Emotions in the room: common emotional reactions to discussions of poor prognosis and tools to address them. Expert review of anticancer therapy. 2019 Aug;19(8):689-696. Epub 2019 Aug 10. PMID: 31382794
  • Champer M, Huang Y, Hou JY, Tergas AI, Burke WM, Hillyer GC, Ananth CV, Neugut AI, Hershman DL, Wright JD. Adherence to treatment recommendations and outcomes for women with ovarian cancer at first recurrence. Gynecologic oncology. 2018 Jan;148(1):19-27. Epub 2017 Nov 16. PMID: 29153542
  • Givens JL, Jones RN, Mazor KM, Prigerson HG, Mitchell SL. Development and psychometric properties of the family distress in advanced dementia scale. Journal of the American Medical Directors Association. 2015 Sep 1;16(9):775-80. Epub 2015 May 1. PMID: 25940236
  • Lilley EJ, Lee KC, Scott JW, Krumrei NJ, Haider AH, Salim A, Gupta R, Cooper Z. The impact of inpatient palliative care on end-of-life care among older trauma patients who die after hospital discharge. The journal of trauma and acute care surgery. 2018 Nov;85(5):992-998. PMID: 29851910
  • Derry HM, Johnston CD, Burchett CO, Siegler EL, Glesby MJ. Gait Speed Is Associated with Cognitive Function among Older Adults with HIV. Journal of aging and health. 2020 Dec;32(10):1510-1515. Epub 2020 Jul 22. PMID: 32697615
  • Dionne-Odom JN, Azuero A, Lyons KD, Hull JG, Prescott AT, Tosteson T, Frost J, Dragnev KH, Bakitas MA. Family Caregiver Depressive Symptom and Grief Outcomes From the ENABLE III Randomized Controlled Trial. Journal of pain and symptom management. 2016 Sep;52(3):378-85. Epub 2016 Jun 3. PMID: 27265814
  • Luth EA, Russell DJ, Brody AA, Dignam R, Czaja SJ, Ryvicker M, Bowles KH, Prigerson HG. Race, Ethnicity, and Other Risks for Live Discharge Among Hospice Patients with Dementia. Journal of the American Geriatrics Society. 2020 Mar;68(3):551-558. Epub 2019 Nov 21. PMID: 31750935
  • Trevino KM, Rutherford SC, Marte C, Ouyang DJ, Martin P, Prigerson HG, Leonard JP. Illness Understanding and Advance Care Planning in Patients with Advanced Lymphoma. Journal of palliative medicine. 2020 Jun;23(6):832-837. Epub 2019 Oct 18. PMID: 31633432
  • Kaplan A, Comisar L, Ufere NN, Jannat-Khah D, Rosenblatt R, Fortune B, Prigerson HG, Brown R Jr. Understanding Prognosis: Discrepancy in Prognosis Estimates Between Patients With Cirrhosis and their Hepatologists. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2023 Apr;21(4):1005-1012.e4. Epub 2022 May 26. PMID: 35643416
  • Lichtenthal WG, Catarozoli C, Masterson M, Slivjak E, Schofield E, Roberts KE, Neimeyer RA, Wiener L, Prigerson HG, Kissane DW, Li Y, Breitbart W. An open trial of meaning-centered grief therapy: Rationale and preliminary evaluation. Palliative & supportive care. 2019 Feb;17(1):2-12. Epub 2019 Jan 26. PMID: 30683164
  • Phongtankuel V, Teresi JA, Eimicke JP, Kong JX, Adelman RD, Prigerson HG, Czaja SJ, Shalev A, Dignam R, Baughn R, Reid MC. Identifying the Prevalence and Correlates of Caregiver-Reported Symptoms in Home Hospice Patients at the End of Life. Journal of palliative medicine. 2020 May;23(5):635-640. Epub 2019 Dec 23. PMID: 31873053
  • Lövgren M, Sveen J, Nyberg T, Eilegård Wallin A, Prigerson HG, Steineck G, Kreicbergs U. Care at End of Life Influences Grief: A Nationwide Long-Term Follow-Up among Young Adults Who Lost a Brother or Sister to Childhood Cancer. Journal of palliative medicine. 2018 Feb;21(2):156-162. Epub 2017 Sep 26. PMID: 28949788
  • Trevino KM, Maciejewski PK, Epstein AS, Prigerson HG. The lasting impact of the therapeutic alliance: Patient-oncologist alliance as a predictor of caregiver bereavement adjustment. Cancer. 2015 Oct 1;121(19):3534-42. Epub 2015 Jun 4. PMID: 26042653
  • Balboni MJ, Sullivan A, Enzinger AC, Smith PT, Mitchell C, Peteet JR, Tulsky JA, VanderWeele T, Balboni TA. U.S. Clergy Religious Values and Relationships to End-of-Life Discussions and Care. Journal of pain and symptom management. 2017 Jun;53(6):999-1009. Epub 2017 Feb 6. PMID: 28185893
  • George LS, Maciejewski PK, Epstein AS, Shen M, Prigerson HG. Advanced Cancer Patients' Changes in Accurate Prognostic Understanding and Their Psychological Well-Being. Journal of pain and symptom management. 2020 May;59(5):983-989. Epub 2019 Dec 28. PMID: 31887399
  • Keating NL, Landrum MB, Huskamp HA, Kouri EM, Prigerson HG, Schrag D, Maciejewski PK, Hornbrook MC, Haggstrom DA. Dartmouth Atlas Area-Level Estimates of End-of-Life Expenditures: How Well Do They Reflect Expenditures for Prospectively Identified Advanced Lung Cancer Patients? Health services research. 2016 Aug;51(4):1584-94. Epub 2016 Jan 22. PMID: 26799913
  • Tergas AI, Prigerson HG, Penedo FJ, Maciejewski PK. Human Connection: Oncologist Characteristics and Behaviors Associated With Therapeutic Bonding With Latino Patients With Advanced Cancer. JCO oncology practice. 2024 Jan;20(1):111-122. Epub 2023 Nov 21. PMID: 37988650
  • Epstein AS, Prigerson HG, O'Reilly EM, Maciejewski PK. Discussions of Life Expectancy and Changes in Illness Understanding in Patients With Advanced Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Jul 10;34(20):2398-403. Epub 2016 May 23. PMID: 27217454
  • Trevino KM, Zhang B, Shen MJ, Prigerson HG. Accuracy of advanced cancer patients' life expectancy estimates: The role of race and source of life expectancy information. Cancer. 2016 Jun 15;122(12):1905-12. Epub 2016 Mar 29. PMID: 27028270
  • Meyer F, Fletcher K, Prigerson HG, Braun IM, Maciejewski PK. Advanced cancer as a risk for major depressive episodes. Psycho-oncology. 2015 Sep;24(9):1080-7. Epub 2014 Nov 12. PMID: 25389107
  • Prigerson HG, Russell D, Kakarala SE, Derry-Vick HM, Shah MA, Saxena A, Reyna VF, Ocean A, Scheff R, Maciejewski PK, Epstein AS. Giving information strategically and transparently: A pilot trial of the Oncolo-GIST intervention to promote patients' prognostic understanding. Cancer medicine. 2023 Sep;12(17):18269-18280. Epub 2023 Aug 8. PMID: 37551156
  • Yu M, Tang S, Wang C, Xiang Z, Yu W, Xu W, Wang J, Prigerson HG. Avoidance of Bereavement-Related Stimuli in Chinese Individuals Experiencing Prolonged Grief: Evidence from a Dot-Probe Task. Frontiers in psychology. 2017 Jul 17;8:1201. doi: 10.3389/fpsyg.2017.01201. eCollection 2017. PMID: 28769844
  • Luth EA, Prigerson HG. Unintended Harm? Race Differences in the Relationship Between Advance Care Planning and Psychological Distress at the End of Life. Journal of pain and symptom management. 2018 Nov;56(5):752-759. Epub 2018 Aug 8. PMID: 30096438
  • Russell D, Luth EA, Ryvicker M, Bowles KH, Prigerson HG. Live Discharge From Hospice Due to Acute Hospitalization: The Role of Neighborhood Socioeconomic Characteristics and Race/Ethnicity. Medical care. 2020 Apr;58(4):320-328. PMID: 31876664
  • Prigerson HG, Vaughan SC, Lichtenthal WG. The hidden dangers of a cancer diagnosis. BMJ (Clinical research ed.). 2016 Aug 31;354:i4446. PMID: 27581497
  • Li D, Prigerson HG, Kang J, Maciejewski PK. Reply to Serin et al. Journal of pain and symptom management. 2017 Jun;53(6):e8-e10. Epub 2017 Apr 22. PMID: 28438585
  • Rodenbach RA, Norton SA, Wittink MN, Mohile S, Prigerson HG, Duberstein PR, Epstein RM. When chemotherapy fails: Emotionally charged experiences faced by family caregivers of patients with advanced cancer. Patient education and counseling. 2019 May;102(5):909-915. Epub 2018 Dec 12. PMID: 30579772
  • Molina N, Viola M, Rogers M, Ouyang D, Gang J, Derry H, Prigerson HG. Suicidal Ideation in Bereavement: A Systematic Review. Behavioral sciences (Basel, Switzerland). 2019 May 14;9. (5). PMID: 31091772
  • Lichtenthal WG, Maciejewski PK, Craig Demirjian C, Roberts KE, First MB, Kissane DW, Neimeyer RA, Breitbart W, Slivjak E, Jankauskaite G, Napolitano S, Maercker A, Prigerson HG. Evidence of the clinical utility of a prolonged grief disorder diagnosis. World psychiatry : official journal of the World Psychiatric Association (WPA). 2018 Oct;17(3):364-365. PMID: 30229568
  • Buckley de Meritens A, Margolis B, Blinderman C, Prigerson HG, Maciejewski PK, Shen MJ, Hou JY, Burke WM, Wright JD, Tergas AI. Practice Patterns, Attitudes, and Barriers to Palliative Care Consultation by Gynecologic Oncologists. Journal of oncology practice. 2017 Sep;13(9):e703-e711. Epub 2017 Aug 7. PMID: 28783424
  • Luth EA, Manful A, Prigerson HG, Xiang L, Reich A, Semco R, Weissman JS. Associations between dementia diagnosis and end-of-life care utilization. Journal of the American Geriatrics Society. 2022 Oct;70(10):2871-2883. Epub 2022 Jul 13. PMID: 35822659
  • Cooper Z, Lilley EJ, Bollens-Lund E, Mitchell SL, Ritchie CS, Lipstiz SR, Kelley AS. High Burden of Palliative Care Needs of Older Adults During Emergency Major Abdominal Surgery. Journal of the American Geriatrics Society. 2018 Nov;66(11):2072-2078. Epub 2018 Sep 24. PMID: 30247747
  • Viola M, Ouyang D, Xu J, Maciejewski PK, Prigerson HG, Derry HM. Associations between beta-blocker use and psychological distress in bereaved adults with cardiovascular conditions. Stress and health : journal of the International Society for the Investigation of Stress. 2022 Feb;38(1):147-153. Epub 2021 May 18. PMID: 33977672
  • Cea ME, Reid MC, Inturrisi C, Witkin LR, Prigerson HG, Bao Y. Pain Assessment, Management, and Control Among Patients 65 Years or Older Receiving Hospice Care in the U.S. Journal of pain and symptom management. 2016 Nov;52(5):663-672. Epub 2016 Sep 29. PMID: 27693900
  • Derry HM, Lief L, Schenck EJ, Berlin DA, Prigerson HG. Peritraumatic Stress among Caregivers of Patients in the Intensive Care Unit. Annals of the American Thoracic Society. 2020 May;17(5):650-654. PMID: 32068429
  • Derry-Vick HM, Heathcote LC, Glesby N, Stribling J, Luebke M, Epstein AS, Prigerson HG. Scanxiety among Adults with Cancer: A Scoping Review to Guide Research and Interventions. Cancers. 2023 Feb 22;15. (5). PMID: 36900174
  • Norton SA, Wittink MN, Duberstein PR, Prigerson HG, Stanek S, Epstein RM. Family caregiver descriptions of stopping chemotherapy and end-of-life transitions. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2019 Feb;27(2):669-675. Epub 2018 Jul 28. PMID: 30056528
  • Diamond EL, Prigerson HG, Correa DC, Reiner A, Panageas K, Kryza-Lacombe M, Buthorn J, Neil EC, Miller AM, DeAngelis LM, Applebaum AJ. Prognostic awareness, prognostic communication, and cognitive function in patients with malignant glioma. Neuro-oncology. 2017 Oct 19;19(11):1532-1541. PMID: 28645200
  • Li D, Prigerson HG, Kang J, Maciejewski PK. Impact of Radiation Therapy on Aggressive Care and Quality of Life Near Death. Journal of pain and symptom management. 2017 Jan;53(1):25-32. Epub 2016 Oct 5. PMID: 27720786
  • Duberstein PR, Maciejewski PK, Epstein RM, Fenton JJ, Chapman B, Norton SA, Hoerger M, Wittink MN, Tancredi DJ, Xing G, Mohile S, Kravitz RL, Prigerson HG. Effects of the Values and Options in Cancer Care Communication Intervention on Personal Caregiver Experiences of Cancer Care and Bereavement Outcomes. Journal of palliative medicine. 2019 Nov;22(11):1394-1400. Epub 2019 Jun 25. PMID: 31237459
  • Derry HM, Maciejewski PK, Epstein AS, Shah MA, LeBlanc TW, Reyna V, Prigerson HG. Associations between Anxiety, Poor Prognosis, and Accurate Understanding of Scan Results among Advanced Cancer Patients. Journal of palliative medicine. 2019 Aug;22(8):961-965. Epub 2019 Feb 6. PMID: 30724692
  • Lambden J, Zhang B, Friedlander R, Prigerson HG. Accuracy of Oncologists' Life-Expectancy Estimates Recalled by Their Advanced Cancer Patients: Correlates and Outcomes. Journal of palliative medicine. 2016 Dec;19(12):1296-1303. Epub 2016 Aug 30. PMID: 27574869
  • Shen MJ, Prigerson HG, Tergas AI, Maciejewski PK. Impact of Immigrant Status on Aggressive Medical Care Counter to Patients' Values Near Death among Advanced Cancer Patients. Journal of palliative medicine. 2019 Jan;22(1):34-40. Epub 2018 Sep 12. PMID: 30207832
  • Kozlov E, Phongtankuel V, Prigerson H, Adelman R, Shalev A, Czaja S, Dignam R, Baughn R, Reid MC. Prevalence, Severity, and Correlates of Symptoms of Anxiety and Depression at the Very End of Life. Journal of pain and symptom management. 2019 Jul;58(1):80-85. Epub 2019 Apr 17. PMID: 31004771
  • Lichtenthal WG, Roberts KE, Catarozoli C, Schofield E, Holland JM, Fogarty JJ, Coats TC, Barakat LP, Baker JN, Brinkman TM, Neimeyer RA, Prigerson HG, Zaider T, Breitbart W, Wiener L. Regret and unfinished business in parents bereaved by cancer: A mixed methods study. Palliative medicine. 2020 Mar;34(3):367-377. Epub 2020 Feb 5. PMID: 32020837
  • Duberstein PR, Kravitz RL, Fenton JJ, Xing G, Tancredi DJ, Hoerger M, Mohile SG, Norton SA, Prigerson HG, Epstein RM. Physician and Patient Characteristics Associated With More Intensive End-of-Life Care. Journal of pain and symptom management. 2019 Aug;58(2):208-215.e1. Epub 2019 Apr 18. PMID: 31004774
  • Chamberlin P, Lambden J, Kozlov E, Maciejewski R, Lief L, Berlin DA, Pelissier L, Yushuvayev E, Pan CX, Prigerson HG. Clinicians' Perceptions of Futile or Potentially Inappropriate Care and Associations with Avoidant Behaviors and Burnout. Journal of palliative medicine. 2019 Sep;22(9):1039-1045. Epub 2019 Mar 15. PMID: 30874470
  • Trevino KM, Prigerson HG, Shen MJ, Tancredi DJ, Xing G, Hoerger M, Epstein RM, Duberstein PR. Association between advanced cancer patient-caregiver agreement regarding prognosis and hospice enrollment. Cancer. 2019 Sep 15;125(18):3259-3265. Epub 2019 May 30. PMID: 31145833
  • Lief L, Berlin DA, Maciejewski RC, Westman L, Su A, Cooper ZR, Ouyang DJ, Epping G, Derry H, Russell D, Gentzler E, Maciejewski PK, Prigerson HG. Dying Patient and Family Contributions to Nurse Distress in the ICU. Annals of the American Thoracic Society. 2018 Dec;15(12):1459-1464. PMID: 30095978
  • Ratshikana-Moloko M, Ayeni O, Tsitsi JM, Wong ML, Jacobson JS, Neugut AI, Sobekwa M, Joffe M, Mmoledi K, Blanchard CL, Mapanga W, Ruff P, Cubasch H, O'Neil DS, Balboni TA, Prigerson HG. Spiritual Care, Pain Reduction, and Preferred Place of Death Among Advanced Cancer Patients in Soweto, South Africa. Journal of pain and symptom management. 2020 Jul;60(1):37-47. Epub 2020 Feb 8. PMID: 32045675
  • Pillemer K, Chen EK, Riffin C, Prigerson H, Reid MC. Practice-Based Research Priorities for Palliative Care: Results From a Research-to-Practice Consensus Workshop. American journal of public health. 2015 Nov;105(11):2237-44. Epub 2015 Sep 17. PMID: 26378859
  • Trevino KM, Maciejewski PK, Shen MJ, Prigerson HG, Mohile S, Kamen C, Epstein RM, Duberstein P. How much time is left? Associations between estimations of patient life expectancy and quality of life in patients and caregivers. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2019 Jul;27(7):2487-2496. Epub 2018 Nov 1. PMID: 30387051
  • She WJ, Prigerson HG. "Caregrieving" in palliative care: Opportunities to improve bereavement services. Palliative medicine. 2018 Dec;32(11):1635-1636. Epub 2018 Jul 6. PMID: 29978734
  • Shen MJ, Prigerson HG, Maciejewski PK. Associations between Latino ethnicity and the use of emotional support and completion of advance directives. Palliative & supportive care. 2023 Jun;21(3):385-391. PMID: 37039467
  • Derry HM, Reid MC, Prigerson HG. Advanced cancer patients' understanding of prognostic information: Applying insights from psychological research. Cancer medicine. 2019 Aug;8(9):4081-4088. Epub 2019 Jun 14. PMID: 31199597
  • Lilley EJ, Cooper Z, Schwarze ML, Mosenthal AC. Palliative Care in Surgery: Defining the Research Priorities. Journal of palliative medicine. 2017 Jul;20(7):702-709. Epub 2017 Mar 24. PMID: 28339313
  • Garrido MM, Prigerson HG, Bao Y, Maciejewski PK. Chemotherapy Use in the Months Before Death and Estimated Costs of Care in the Last Week of Life. Journal of pain and symptom management. 2016 May;51(5):875-881.e2. Epub 2016 Feb 17. PMID: 26899821
  • Viola M, Gang J, Maciejewski PK, Prigerson HG. Associations of financial hardship with suicidal ideation among bereaved cancer caregivers. Journal of psychosocial oncology. 2023;41(2):226-234. Epub 2022 May 5. PMID: 35510901
  • Falzarano F, Prigerson HG, Maciejewski PK. The Role of Advance Care Planning in Cancer Patient and Caregiver Grief Resolution: Helpful or Harmful? Cancers. 2021 Apr 20;13. (8). PMID: 33924214
  • Lichtenthal WG, Roberts KE, Prigerson HG. Bereavement Care in the Wake of COVID-19: Offering Condolences and Referrals. Annals of internal medicine. 2020 Nov 17;173(10):833-835. Epub 2020 Jun 23. PMID: 32574071
  • Prigerson HG, Maciejewski PK. Rebuilding Consensus on Valid Criteria for Disordered Grief. JAMA psychiatry. 2017 May 1;74(5):435-436. PMID: 28355449
  • Goldstein RD, Lederman RI, Lichtenthal WG, Morris SE, Human M, Elliott AJ, Tobacco D, Angal J, Odendaal H, Kinney HC, Prigerson HG, PASS Network. The Grief of Mothers After the Sudden Unexpected Death of Their Infants. Pediatrics. 2018 May;141. (5). PMID: 29712764
  • Lichtenthal WG, Sweeney CR, Roberts KE, Corner GW, Donovan LA, Prigerson HG, Wiener L. Bereavement Follow-Up After the Death of a Child as a Standard of Care in Pediatric Oncology. Pediatric blood & cancer. 2015 Dec;62 Suppl 5(0):S834-69. PMID: 26700929
  • Gentzler ER, Derry H, Ouyang DJ, Lief L, Berlin DA, Xu CJ, Maciejewski PK, Prigerson HG. Underdetection and Undertreatment of Dyspnea in Critically Ill Patients. American journal of respiratory and critical care medicine. 2019 Jun 1;199(11):1377-1384. PMID: 30485121
  • George LS, Balboni TA, Maciejewski PK, Epstein AS, Prigerson HG. "My doctor says the cancer is worse, but I believe in miracles"-When religious belief in miracles diminishes the impact of news of cancer progression on change in prognostic understanding. Cancer. 2020 Feb 15;126(4):832-839. Epub 2019 Oct 28. PMID: 31658374
  • Loh KP, Xu H, Epstein RM, Mohile SG, Prigerson HG, Plumb S, Ladwig S, Kadambi S, Wong ML, McHugh C, An A, Trevino K, Saeed F, Duberstein PR. Associations of Caregiver-Oncologist Discordance in Prognostic Understanding With Caregiver-Reported Therapeutic Alliance and Anxiety. Journal of pain and symptom management. 2020 Jul;60(1):20-27. Epub 2020 Feb 13. PMID: 32061833
  • Sharma RK, Prigerson HG, Penedo FJ, Maciejewski PK. Male-female patient differences in the association between end-of-life discussions and receipt of intensive care near death. Cancer. 2015 Aug 15;121(16):2814-20. Epub 2015 May 14. PMID: 25975179
  • Cham S, Huang Y, Tergas AI, Hou JY, Burke WM, Deutsch I, Ananth CV, Neugut AI, Hershman DL, Wright JD. Utility of radiation therapy for early-stage uterine papillary serous carcinoma. Gynecologic oncology. 2017 May;145(2):269-276. Epub 2017 Mar 23. PMID: 28343693
  • Falzarano F, Siedlecki KL. Differences in cognitive performance between informal caregivers and non-caregivers. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 2021 Mar;28(2):284-307. Epub 2020 Apr 9. PMID: 32270735
  • Neugut AI, Prigerson HG. Curative, Life-Extending, and Palliative Chemotherapy: New Outcomes Need New Names. The oncologist. 2017 Aug;22(8):883-885. Epub 2017 May 26. PMID: 28550031
  • Sharma RK, Cameron KA, Chmiel JS, Von Roenn JH, Szmuilowicz E, Prigerson HG, Penedo FJ. Racial/Ethnic Differences in Inpatient Palliative Care Consultation for Patients With Advanced Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Nov 10;33(32):3802-8. Epub 2015 Aug 31. PMID: 26324373
  • Chughtai B, Westman L, Maciejewski PK, Su A, Lief L, Berlin D, Prigerson HG. Urinary Incontinence and Quality of Death in the Intensive Care Unit. Journal of palliative medicine. 2017 Oct;20(10):1054-1055. Epub 2017 Jun 30. PMID: 28665751
  • Maciejewski PK, Maercker A, Boelen PA, Prigerson HG. "Prolonged grief disorder" and "persistent complex bereavement disorder", but not "complicated grief", are one and the same diagnostic entity: an analysis of data from the Yale Bereavement Study. World psychiatry : official journal of the World Psychiatric Association (WPA). 2016 Oct;15(3):266-275. PMID: 27717273
  • Galatsch M, Prigerson HG, Schnepp W, Zu Sayn-Wittgenstein F, Li J. Caregiver exposure to critical events and distress in home-based palliative care in Germany a cross-sectional study using the Stressful Caregiving Adult Reactions to Experiences of Dying (SCARED) scale. BMC palliative care. 2019 Jan 24;18(1):9. PMID: 30678682
  • Epstein AS, Kakarala SE, Reyna VF, Saxena A, Maciejewski PK, Shah MA, Prigerson HG. Development of the Oncolo-GIST ("Giving Information Strategically & Transparently") Intervention Manual for Oncologist Skills Training in Advanced Cancer Prognostic Information Communication. Journal of pain and symptom management. 2021 Jul;62(1):10-19.e4. Epub 2020 Nov 27. PMID: 33253786
  • Blanchard CL, Ayeni O, O'Neil DS, Prigerson HG, Jacobson JS, Neugut AI, Joffe M, Mmoledi K, Ratshikana-Moloko M, Sackstein PE, Ruff P. A Prospective Cohort Study of Factors Associated With Place of Death Among Patients With Late-Stage Cancer in Southern Africa. Journal of pain and symptom management. 2019 May;57(5):923-932. Epub 2019 Jan 30. PMID: 30708125
  • Su A, Lief L, Berlin D, Cooper Z, Ouyang D, Holmes J, Maciejewski R, Maciejewski PK, Prigerson HG. Beyond Pain: Nurses' Assessment of Patient Suffering, Dignity, and Dying in the Intensive Care Unit. Journal of pain and symptom management. 2018 Jun;55(6):1591-1598.e1. Epub 2018 Feb 17. PMID: 29458082
  • Cohen SM, Maciejewski RC, Shah MA, Trevino KM, Shen MJ, Maciejewski PK, Prigerson HG. Being present: oncologists' role in promoting advanced cancer patients' illness understanding. Cancer medicine. 2018 Apr;7(4):1511-1518. Epub 2018 Feb 26. PMID: 29479843
  • Luth EA, Russell DJ, Xu JC, Lauder B, Ryvicker MB, Dignam RR, Baughn R, Bowles KH, Prigerson HG. Survival in hospice patients with dementia: the effect of home hospice and nurse visits. Journal of the American Geriatrics Society. 2021 Jun;69(6):1529-1538. Epub 2021 Feb 19. PMID: 33608869
  • Trevino KM, Prigerson HG, Maciejewski PK. Advanced cancer caregiving as a risk for major depressive episodes and generalized anxiety disorder. Psycho-oncology. 2018 Jan;27(1):243-249. Epub 2017 May 16. PMID: 28426918
  • Balboni TA, Prigerson HG, Balboni MJ, Enzinger AC, VanderWeele TJ, Maciejewski PK. A scale to assess religious beliefs in end-of-life medical care. Cancer. 2019 May 1;125(9):1527-1535. Epub 2019 Mar 2. PMID: 30825390
  • Lichtenthal WG, Lief L, Rogers M, Russell D, Viola M, Winoker H, Kakarala S, Traube C, Coats T, Fadalla C, Roberts KE, Pavao M, Osso F, Brewin CR, Pan CX, Maciejewski PK, Berlin D, Pastores S, Halpern N, Vaughan SC, Cox CE, Prigerson HG. EMPOWER: A Multi-Site Pilot Trial to Reduce Distress in Surrogate Decision-Makers in the ICU. Journal of pain and symptom management. 2024 Jun;67(6):512-524.e2. Epub 2024 Mar 11. PMID: 38479536
  • Shalev A, Phongtankuel V, Reid MC, Czaja SJ, Dignam R, Baughn R, Newmark M, Prigerson HG, Teresi J, Adelman RD. Home Hospice Caregivers' Perceived Information Needs. The American journal of hospice & palliative care. 2019 Apr;36(4):302-307. Epub 2018 Oct 9. PMID: 30301363
  • Lichtenthal WG, Viola M, Rogers M, Roberts KE, Lief L, Cox CE, Brewin CR, Xu JC, Maciejewski PK, Pan CX, Coats T, Ouyang DJ, Rabin S, Vaughan SC, Breitbart W, Marenberg ME, Prigerson HG. Development and preliminary evaluation of EMPOWER for surrogate decision-makers of critically ill patients. Palliative & supportive care. 2022 Apr;20(2):167-177. PMID: 34233779
  • Prigerson HG, Boelen PA, Xu J, Smith KV, Maciejewski PK. Validation of the new DSM-5-TR criteria for prolonged grief disorder and the PG-13-Revised (PG-13-R) scale. World psychiatry : official journal of the World Psychiatric Association (WPA). 2021 Feb;20(1):96-106. PMID: 33432758
  • Jabbarian LJ, Maciejewski RC, Maciejewski PK, Rietjens JAC, Korfage IJ, van der Heide A, van Delden JJM, Prigerson HG. The Stability of Treatment Preferences Among Patients With Advanced Cancer. Journal of pain and symptom management. 2019 Jun;57(6):1071-1079.e1. Epub 2019 Feb 19. PMID: 30794935
  • Luth EA, Prigerson HG. Socioeconomic Status, Race/Ethnicity, and Unexpected Variation in Dementia Classification in Longitudinal Survey Data. The journals of gerontology. Series B, Psychological sciences and social sciences. 2022 Dec 29;77(12):e234-e246. PMID: 36048568
  • Kurita K, Reid MC, Siegler EL, Diamond EL, Prigerson HG. Associations between Mild Cognitive Dysfunction and End-of-Life Outcomes in Patients with Advanced Cancer. Journal of palliative medicine. 2018 Apr;21(4):536-540. Epub 2018 Jan 3. PMID: 29298104
  • Hahne J, Carpenter BD, Epstein AS, Prigerson HG, Derry-Vick HM. Communication Skills Training for Oncology Clinicians After the 21st Century Cures Act: The Need to Contextualize Patient Portal-Delivered Test Results. JCO oncology practice. 2023 Mar;19(3):99-102. Epub 2022 Nov 10. PMID: 36356282
  • Garrido MM, Prigerson HG, Neupane S, Penrod JD, Johnson CE, Boockvar KS. Mental Illness and Mental Healthcare Receipt among Hospitalized Veterans with Serious Physical Illnesses. Journal of palliative medicine. 2017 Mar;20(3):247-252. Epub 2016 Nov 11. PMID: 27835066
  • Maciejewski PK, Falzarano FB, She WJ, Lichtenthal WG, Prigerson HG. A micro-sociological theory of adjustment to loss. Current opinion in psychology. 2022 Feb;43:96-101. Epub 2021 Jul 7. PMID: 34333375
  • Phongtankuel V, Shalev A, Adelman RD, Dewald R, Dignam R, Baughn R, Prigerson HG, Teresi J, Czaja SJ, Reid MC. Mobile Health Technology Is Here-But Are Hospice Informal Caregivers Receptive? The American journal of hospice & palliative care. 2018 Dec;35(12):1547-1552. Epub 2018 Jun 3. PMID: 29862851
  • Kurita K, Lachs MS, Adelman RD, Siegler EL, Reid MC, Prigerson HG. Mild cognitive dysfunction of caregivers and its association with care recipients' end-of-life plans and preferences. PloS one. 2018 Apr 30;13(4):e0196147. doi: 10.1371/journal.pone.0196147. eCollection 2018. PMID: 29708996
  • Gang J, Falzarano F, She WJ, Winoker H, Prigerson HG. Are deaths from COVID-19 associated with higher rates of prolonged grief disorder (PGD) than deaths from other causes? Death studies. 2022;46(6):1287-1296. Epub 2022 Feb 15. PMID: 35167429
  • Prigerson HG, Viola M, Maciejewski PK, Falzarano F. Advance care planning (ACP) to promote receipt of value-concordant care: Results vary according to patient priorities. PloS one. 2023 Jan 11;18(1):e0280197. doi: 10.1371/journal.pone.0280197. eCollection 2023. PMID: 36630471
  • Ramer SJ, Viola M, Maciejewski PK, Reid MC, Prigerson HG. Suffering and Symptoms At the End of Life in ICU Patients Undergoing Renal Replacement Therapy. The American journal of hospice & palliative care. 2021 Dec;38(12):1509-1515. Epub 2021 Apr 8. PMID: 33827273
  • An AW, Ladwig S, Epstein RM, Prigerson HG, Duberstein PR. The impact of the caregiver-oncologist relationship on caregiver experiences of end-of-life care and bereavement outcomes. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2020 Sep;28(9):4219-4225. Epub 2020 Jan 3. PMID: 31900620
  • Margolis B, Chen L, Accordino MK, Clarke Hillyer G, Hou JY, Tergas AI, Burke WM, Neugut AI, Ananth CV, Hershman DL, Wright JD. Trends in end-of-life care and health care spending in women with uterine cancer. American journal of obstetrics and gynecology. 2017 Oct;217(4):434.e1-434.e10. Epub 2017 Jul 11. PMID: 28709581
  • Kakarala SE, Roberts KE, Rogers M, Coats T, Falzarano F, Gang J, Chilov M, Avery J, Maciejewski PK, Lichtenthal WG, Prigerson HG. The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review. Psychiatry research. Neuroimaging. 2020 Sep 30;303:111135. Epub 2020 Jul 3. PMID: 32629197
  • Bao Y, Maciejewski RC, Garrido MM, Shah MA, Maciejewski PK, Prigerson HG. Chemotherapy Use, End-of-Life Care, and Costs of Care Among Patients Diagnosed With Stage IV Pancreatic Cancer. Journal of pain and symptom management. 2018 Apr;55(4):1113-1121.e3. Epub 2017 Dec 11. PMID: 29241809
  • Lilley EJ, Cooper Z, Schwarze ML, Mosenthal AC. Palliative Care in Surgery: Defining the Research Priorities. Annals of surgery. 2018 Jan;267(1):66-72. PMID: 28471764
  • Luth EA, Prigerson HG. Associations between Race and Dementia Status and the Quality of End-of-Life Care. Journal of palliative medicine. 2018 Jul;21(7):970-977. Epub 2018 Apr 5. PMID: 29620949
  • Luth EA, Pan CX, Viola M, Prigerson HG. Dementia and Early Do-Not-Resuscitate Orders Associated With Less Intensive of End-of-Life Care: A Retrospective Cohort Study. The American journal of hospice & palliative care. 2021 Dec;38(12):1417-1425. Epub 2021 Jan 20. PMID: 33467864
  • Russell D, Diamond EL, Lauder B, Dignam RR, Dowding DW, Peng TR, Prigerson HG, Bowles KH. Frequency and Risk Factors for Live Discharge from Hospice. Journal of the American Geriatrics Society. 2017 Aug;65(8):1726-1732. Epub 2017 Mar 13. PMID: 28295138
  • Shen MJ, Prigerson HG, Ratshikana-Moloko M, Mmoledi K, Ruff P, Jacobson JS, Neugut AI, Amanfu J, Cubasch H, Wong M, Joffe M, Blanchard C. Illness Understanding and End-of-Life Care Communication and Preferences for Patients With Advanced Cancer in South Africa. Journal of global oncology. 2018 Sep;4:1-9. PMID: 30241251
  • Shen MJ, Gonzalez C, Leach B, Maciejewski PK, Kozlov E, Prigerson HG. An examination of Latino advanced cancer patients' and their informal caregivers' preferences for communication about advance care planning: A qualitative study. Palliative & supportive care. 2020 Jun;18(3):277-284. PMID: 31699175
  • Shen MJ, Trevino KM, Prigerson HG. The interactive effect of advanced cancer patient and caregiver prognostic understanding on patients' completion of Do Not Resuscitate orders. Psycho-oncology. 2018 Jul;27(7):1765-1771. Epub 2018 Apr 30. PMID: 29611241
  • Enzinger AC, Zhang B, Schrag D, Prigerson HG. Outcomes of Prognostic Disclosure: Associations With Prognostic Understanding, Distress, and Relationship With Physician Among Patients With Advanced Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Nov 10;33(32):3809-16. Epub 2015 Oct 5. PMID: 26438121
  • George LS, Breitbart W, Prigerson HG. "My Family Wants Something Different": Discordance in Perceived Personal and Family Treatment Preference and Its Association With Do-Not-Resuscitate Order Placement. Journal of oncology practice. 2019 Nov;15(11):e942-e947. Epub 2019 Sep 11. PMID: 31509484
  • Shen MJ, Prigerson HG, Paulk E, Trevino KM, Penedo FJ, Tergas AI, Epstein AS, Neugut AI, Maciejewski PK. Impact of end-of-life discussions on the reduction of Latino/non-Latino disparities in do-not-resuscitate order completion. Cancer. 2016 Jun 1;122(11):1749-56. Epub 2016 Mar 15. PMID: 26992109
  • Gang J, Kocsis J, Avery J, Maciejewski PK, Prigerson HG. Naltrexone treatment for prolonged grief disorder: study protocol for a randomized, triple-blinded, placebo-controlled trial. Trials. 2021 Feb 1;22(1):110. PMID: 33522931
  • Roberts K, Holland J, Prigerson HG, Sweeney C, Corner G, Breitbart W, Lichtenthal WG. Development of the Bereavement Risk Inventory and Screening Questionnaire (BRISQ): Item generation and expert panel feedback. Palliative & supportive care. 2017 Feb;15(1):57-66. Epub 2016 Aug 12. PMID: 27516152
  • Prigerson HG, Neugut AI. You Get (offered) What You (can) Pay for: Explaining Disparities in End-of-Life Cancer Care. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Oct 20;41(30):4721-4723. Epub 2023 Jun 20. PMID: 37339386
  • Prigerson HG, Viola M, Brewin CR, Cox C, Ouyang D, Rogers M, Pan CX, Rabin S, Xu J, Vaughan S, Gordon-Elliot JS, Berlin D, Lief L, Lichtenthal WG. Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial. Trials. 2019 Jul 9;20(1):408. PMID: 31288829
  • Trevino KM, Litz B, Papa A, Maciejewski PK, Lichtenthal W, Healy C, Prigerson HG. Bereavement Challenges and Their Relationship to Physical and Psychological Adjustment to Loss. Journal of palliative medicine. 2018 Apr;21(4):479-488. Epub 2017 Nov 28. PMID: 29182478
  • Luth EA, Maciejewski PK, Phongtankuel V, Xu J, Prigerson HG. Associations Between Hospice Care and Scary Family Caregiver Experiences. Journal of pain and symptom management. 2021 May;61(5):909-916. Epub 2020 Oct 7. PMID: 33038426
  • Derry HM, Lief L, Woubeshet N, Schenck EJ, Kakarala S, LaFond E, Berlin DA, Prigerson HG. Peritraumatic Stress Symptoms during Early Post-Intensive Care Unit Recovery. Annals of the American Thoracic Society. 2021 Feb;18(2):364-367. PMID: 32870018
  • Shalev A, Phongtankuel V, Kozlov E, Shen MJ, Adelman RD, Reid MC. Awareness and Misperceptions of Hospice and Palliative Care: A Population-Based Survey Study. The American journal of hospice & palliative care. 2018 Mar;35(3):431-439. Epub 2017 Jun 20. PMID: 28631493
  • Kurita K, Siegler EL, Reid MC, Maciejewski RC, Prigerson HG. It Is Not What You Think: Associations Between Perceived Cognitive and Physical Status and Prognostic Understanding in Patients With Advanced Cancer. Journal of pain and symptom management. 2018 Aug;56(2):259-263. Epub 2018 May 10. PMID: 29753102
  • O'Neil DS, Prigerson HG, Mmoledi K, Sobekwa M, Ratshikana-Moloko M, Tsitsi JM, Cubasch H, Wong ML, Omoshoro-Jones JAO, Sackstein PE, Blinderman CD, Jacobson JS, Joffe M, Ruff P, Neugut AI, Blanchard CL. Informal Caregiver Challenges for Advanced Cancer Patients During End-of-Life Care in Johannesburg, South Africa and Distinctions Based on Place of Death. Journal of pain and symptom management. 2018 Jul;56(1):98-106. Epub 2018 Mar 28. PMID: 29604380