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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Fuschiotti, Patrizia

University Of Pittsburgh At Pittsburgh
United States

Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides 5R21CA280445-02 Wendy Wang, Ph.D., M.Sc.
Garcia, Jose M.

Seattle Inst For Biomedical/Clinical Res
United States

SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT) 5R01CA279220-03 Marjorie Perloff, M.D.
Geisler, Stefanie

Washington University
United States

Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy 5R37CA267905-05 Asad Umar, D.V.M., Ph.D.
Gill, Brian John Andrew

Columbia University Health Sciences
United States

The Impact of Local and Reversible Change to GABAergic Inhibitory Signaling on Tumor-Induced Cortical Dysfunction in Glioma 1R01NS140658-01A1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Gonzalez, Brian D

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment 5R01CA287666-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Goode, Diana J

University Of New England
United States

Novel expression of MHC class II on DRG neurons and its role in promoting antinociceptive CD4+ T cells in females during chemotherapy-induced peripheral neuropathy 5R01CA267554-04 Rachel Altshuler, Ph.D.
Groninger, J. Hunter

Medstar Health Research Institute
United States

Cognitive behavioral theory-assisted virtual reality for chronic cancer pain (VR-CAN): device prototype development and feasibility testing 1R21CA299799-01 Brennan Streck, Ph.D., RN, M.P.H.
Grossman, Douglas

Utah State Higher Education System--University Of Utah
United States

Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma 5R21CA289101-02 Nicholas Hodges, Ph.D.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 5R01CA251136-06 Marjorie Perloff, M.D.
Hu, Jim

Weill Medical Coll Of Cornell Univ
United States

Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL) 5R01CA259173-04 Marjorie Perloff, M.D.
Hu, Shuiying

Ohio State University
United States

Targeting neuronal transport to ameliorate vincristine neurotoxicity 5R01CA272254-03 Rachel Altshuler, Ph.D.
Huberty, Jennifer Lynne

University Of Texas Hlth Science Center
United States

Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patients 5R01CA262041-05 Marjorie Perloff, M.D.
Hui, David

University Of Tx Md Anderson Can Ctr
United States

Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology 5R01CA288515-02 Brennan Streck, Ph.D., RN, M.P.H.
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.
Im, Eun-Ok

University Of Texas At Austin
United States

Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors 5R33CA280979-04 Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Status
Title Sort descending Intervention Sponsor Status
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy fractionated stereotactic radiosurgery (FSRS), single fraction stereotactic radiosurgery (SSRS) Wake Forest University Health Sciences Active, not recruiting
Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment Counseling, Health Education, Interview, Medical Chart Review, Monitoring, Questionnaire Administration NRG Oncology Recruiting
Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia Acupuncture - Group 1, Acupuncture - Group 2, Questionnaire, Standard Care M.D. Anderson Cancer Center Active, not recruiting
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM) Best Practice, Financial Navigation, Interview, Survey Administration ECOG-ACRIN Cancer Research Group Recruiting
Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial Internet-based Intervention Wake Forest University Health Sciences Active, not recruiting
Dexamethasone in Controlling Dyspnea in Patients With Cancer Dexamethasone, Questionnaire Administration, Placebo M.D. Anderson Cancer Center Active, not recruiting
Distance-Based Exercise to Preserve Function and Prevent Disability Accelerometry, Aerobic Exercise Intervention, Electronic Health Record Review, Exercise Intervention, Exercise intervention, Interview, Questionnaire Administration, Telemedicine Alliance for Clinical Trials in Oncology Recruiting
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online NRG Oncology Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Recruiting