Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Major Program
NCI Community Oncology Research Program
Supportive Care and Symptom Management
Research Group
Community Oncology and Prevention Trials
Wake Forest University Health Sciences
Not yet recruiting ID
For more information, see NCT05703269
This study is designed to see if we can lower the chance of side effects from radiation in
patients with breast, kidney, non-small cell lung cancer or melanoma that has spread to the
brain and who are also being treated with immunotherapy, specifically immune checkpoint
inhibitor (ICI) therapy. This study will compare the usual care treatment of single fraction
stereotactic radiosurgery (SSRS) given on one day versus fractionated stereotactic
radiosurgery (FSRS), which is a lower dose of radiation given over a few days to determine if
FSRS is better or worse at reducing side effects than usual care treatment.
single fraction stereotactic radiosurgery (SSRS), fractionated stereotactic radiosurgery (FSRS)
NSCLC, Renal Cell Carcinoma, Breast Carcinoma, Melanoma, Brain Metastases, Adult, Non-small Cell Lung Cancer
Christina K Cramer, MD

See list of participating sites