Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

This phase II/III trial studies the best dose of duloxetine and how well it works in
preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with
oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount
of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in
patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent
peripheral neuropathy.

Intervention

Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration

Condition

Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8

Investigators

Ellen M. Lavoie Smith, PhD, Thomas W. Butler, Alison K. Conlin, Richard L. Deming, Jay W. Carlson, Lisa Bailey, Bogdan S. Eftimie, Robert J. Hoyer, Wylie D. Hosmer, Salvatore A. Del Prete, Gregory A. Masters, Mohamedtaki A. Tejani, Mike Cusnir, Elie G. Dib, Howard A. Zaren, John M. Schallenkamp, Suparna Mantha, Bryan A. Faller, Asha R. Dhanarajan, Sheetal M. Kircher, Thomas E. Lad, John D. Abad, Robert d. Marsh, Mark F. Kozloff, Isoken Koko, Shylendra B. Sreenivasappa, Howard M. Gross, Debra M. Prow, William P. Fusselman, Deborah W. Wilbur, Shaker R. Dakhil, Gary C. Doolittle, David S. Hanson, Srikanth Tamma, Rachit Kumar, Sarah J. Sinclair, Gang Chen, Ashkan Bahrani, Julie C. Fu, Marianne T. Huben, Preston D. Steen, David M. King, Joleen M. Hubbard, Liudmila N. Schafer, Timothy Huyck, Ursa A. Brown-Glaberman, Jeffrey J. Kirshner, Eric Bravin, Samer S. Kasbari, Sunitha Vemulapalli, Jordan Kharofa, Sagila George, Anuradha Krishnamurthy, Paul E. O'Brien, Asheesh Shipstone, Karen Riggins, Yvonne H. Sada, Timothy L. Cannon, Zhijian Chen, Mohammed Saad, William J. Irvin, Xin Yao, Francis J. Cuevas, Adedayo A. Onitilo, Sameer Tolay, Anthony J. Jaslowski, Timothy R. Wassenaar, Joni A. Tilford, James E. Radford, Deborah O. Heros, Nibal Saad, Binu Malhotra, Donald J. Jurgens, Steven Ades, John J. Inzerillo, Camille Adeimy, Jason C. Lee, Thomas J. Summers, Joshua Lukenbill, Rachael A. Safyan, Namita Sharma, Vineela Kasireddy, Ki Y. Chung, Sakti Chakrabarti, Kathryn M. Leininger

See list of participating sites