Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer

This phase II trial studies how well docetaxel or paclitaxel work in reducing
chemotherapy-induced peripheral neuropathy in African American patients with stages I-III
breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in
different ways to stop the growth of tumor cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. It is not yet known whether giving
docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced
peripheral neuropathy in patients with breast cancer.

Intervention

Docetaxel, Paclitaxel, Quality-of-Life Assessment, Questionnaire Administration

Condition

Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Invasive Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8

Investigators

Bryan P Schneider, Bryan A. Faller, Alison K. Conlin, Thomas E. Lad, Steven A. Madden, Erica M. Stringer-Reasor, Nicholas DiBella, Jay W. Carlson, Philip E. Lammers, Lisa Bailey, Gregory A. Masters, Shruti R. Tiwari, Antonio C. Wolff, Elie G. Dib, Karen C. Daily, Jane L. Meisel, Cheryl F. Jones, Andrew W. Pippas, John A. Pablo, Maria T. Grosse-Perdekamp, Ami N. Shah, Bryan P. Schneider, David S. Hanson, Agustin A. Garcia, Diana H. Griffiths, Mary S. De Shields, Grace Makari-Judson, Kathleen J. Yost, David M. King, Timothy P. Rearden, Elizabeth C. Reed, Jill S. Morrison, Coral O. Omene, Bonni L. Guerin, Carl J. Minniti, Maysa M. Abu-Khalaf, Della F. Makower, Paul M. Barr, Cynthia Owusu, Timothy D. Moore, William Tse, Albert S. DeNittis, Kristen D. Whitaker, Frank J. Brescia, Ernest Hymel, Kelvin B. Raybon, William J. Irvin, Rubina Qamar, John A. Ellerton, Flavio W. Kruter, Yadyra Rivera, Kathryn M. Leininger

See list of participating sites