Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title	Grant Number Sort descending	Program Official
Acharya, Munjal M	University Of California-Irvine United States	Stem cell-derived exosomes to ameliorate chemobrain	5R01CA262213-03	Rachel Altshuler, Ph.D.
Khasabov, Sergey G	University Of Minnesota United States	Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling	5R01CA263777-05	Rachel Altshuler, Ph.D.
Sohl, Stephanie Jean	Wake Forest University Health Sciences United States	REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE)	5R01CA266995-04	Goli Samimi, Ph.D., M.P.H.
Goode, Diana J	University Of New England United States	Novel expression of MHC class II on DRG neurons and its role in promoting antinociceptive CD4+ T cells in females during chemotherapy-induced peripheral neuropathy	5R01CA267554-04	Rachel Altshuler, Ph.D.
Ross, Stephen	New York University School Of Medicine United States	Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress	5R01CA268521-04	Rachel Altshuler, Ph.D.
Pyter, Leah M	Ohio State University United States	Chemotherapy-induced circadian master clock disruptions and fatigue	5R01CA270372-04	Marjorie Perloff, M.D.
Rini, Christine	Northwestern University At Chicago United States	Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial	5R01CA271220-04	Brennan Streck, Ph.D., RN, M.P.H.
Damaj, M. Imad	Virginia Commonwealth University United States	Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms	5R01CA272147-03	Rachel Altshuler, Ph.D.
Hu, Shuiying	Ohio State University United States	Targeting neuronal transport to ameliorate vincristine neurotoxicity	5R01CA272254-03	Rachel Altshuler, Ph.D.
Cohen, Lorenzo	University Of Tx Md Anderson Can Ctr United States	Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery	5R01CA272565-03	Brennan Streck, Ph.D., RN, M.P.H.
Brown, Austin L	Baylor College Of Medicine United States	A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia	5R01CA272981-03	Rachel Altshuler, Ph.D.
Yang, Qing	University Of Texas Med Br Galveston United States	The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy	5R01CA273001-02	Rachel Altshuler, Ph.D.
Afshar-Kharghan, Vahid	University Of Tx Md Anderson Can Ctr United States	Novel Biomarkers Predicting Blood Clots in Ovarian Cancer	5R01CA275762-03	Rachel Altshuler, Ph.D.
Staff, Nathan P	Mayo Clinic Rochester United States	Investigating the role of MAP2 in chemotherapy-induced peripheral neurotoxicity	5R01CA275870-04	Rachel Altshuler, Ph.D.
Panigrahy, Dipak	Beth Israel Deaconess Medical Center United States	Control of cancer cachexia via stimulation of resolution of inflammation	5R01CA276107-03	Marjorie Perloff, M.D.

Clinical Trials

Title	Intervention	Sponsor	Status
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial	Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention	University of Rochester	Recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors	Aerobic Exercise Training, Attention Control	University of Alabama at Birmingham	Active, not recruiting
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care	Haloperidol, Lorazepam, Placebo, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Active, not recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors	Biospecimen Collection, Questionnaire Administration	SWOG Cancer Research Network	Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer	Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping	NRG Oncology	Recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials	Questionnaires	Eastern Cooperative Oncology Group	Recruiting
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making	Usual Care, Web-based decision aid	Alliance for Clinical Trials in Oncology	Active, not recruiting
IVIG for Infection Prevention After CAR-T-Cell Therapy	Anti-CD19 CAR T Cells Preparation, Biospecimen Collection, Electronic Health Record Review, Immune Globulin Infusion (Human), 10% Solution, Saline, Survey Administration	Fred Hutchinson Cancer Center	Recruiting
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant	Allogeneic Hematopoietic Stem Cell Transplantation, Lactobacillus plantarum strain 299, Lactobacillus plantarum strain 299v, Placebo Administration	Children's Oncology Group	Active, not recruiting
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula	Biospecimen Collection, Distal Pancreatectomy, Lanreotide, Questionnaire Administration, Saline	SWOG Cancer Research Network	Recruiting