Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name	PI Organization	Title	Grant Number	Program Official
Bower, Julienne E	University Of California Los Angeles United States	Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings	5R01CA282416-02	Brennan Streck, Ph.D., RN, M.P.H.
Mosher, Catherine E	Indiana University Indianapolis United States	Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer	5R01CA289486-02
Cohen, Lorenzo	University Of Tx Md Anderson Can Ctr United States	Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery	5R01CA272565-03	Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.	H. Lee Moffitt Cancer Ctr & Res Inst United States	Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue	5R01CA214647-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Rogers, Laura Q	University Of Alabama At Birmingham United States	Role of gut microbe composition in psychosocial symptom response to exercise training in breast cancer survivors	5R01CA235598-06	Gabriela Riscuta, M.D., CNS
Hanks, Brent Allen	Univ Of North Carolina Chapel Hill United States	Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities	5R01CA251136-06	Marjorie Perloff, M.D.
Sedrak, Mina S	University Of California Los Angeles United States	Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline	5R01CA280088-03	Goli Samimi, Ph.D., M.P.H.
Peppone, Luke Joseph	University Of Rochester United States	High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients	5R01CA258349-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wang, Hsiao-Lan	University Of Alabama At Birmingham United States	A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment	5R01CA244947-06	Goli Samimi, Ph.D., M.P.H.
Kahalley, Lisa Schum	Baylor College Of Medicine United States	Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.	3R01CA249988-05S3	Rachel Altshuler, Ph.D.
Hu, Shuiying	Ohio State University United States	Targeting neuronal transport to ameliorate vincristine neurotoxicity	5R01CA272254-03	Rachel Altshuler, Ph.D.
Khasabov, Sergey G	University Of Minnesota United States	Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling	5R01CA263777-05	Rachel Altshuler, Ph.D.
Somers, Tamara J	Duke University United States	A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial	5R01CA237892-05	Brennan Streck, Ph.D., RN, M.P.H.
Palesh, Oxana G	Virginia Commonwealth University United States	Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia	5R01CA239714-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Bao, Ting	Dana-Farber Cancer Inst United States	Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial	5R01CA251470-06	Goli Samimi, Ph.D., M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer	Chemotherapy, Functional Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors	Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	University of Rochester NCORP Research Base	Active, not recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Taxane and Taxane-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer	Docetaxel, Paclitaxel, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Learning Collaborative Versus Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer and Their Caregivers	Behavioral, Psychological or Informational Intervention, Educational Intervention, Medical Examination Assessment, Quality-of-Life Assessment, Survey Administration, Telephone-Based Intervention	University of Rochester NCORP Research Base	Active, not recruiting
A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer	Best Practice, Focus Group, Questionnaire Administration, Text Message	Thomas Jefferson University	Active, not recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors	Aerobic Exercise Training, Attention Control	University of Alabama at Birmingham	Active, not recruiting
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study	Educational Intervention, FitBit, Goal Setting, Health Promotion and Education, Media Intervention, Telephone-Based Intervention	Children's Oncology Group	Active, not recruiting
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy	Best Practice, Educational Intervention, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration, Text Message-based Navigation Intervention	Alliance for Clinical Trials in Oncology	Active, not recruiting