Program Official

Principal Investigator

Awardee Organization

Dana-Farber Cancer Inst
United States

Fiscal Year
Activity Code
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial

Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is no effective treatment for it. Our pilot phase IIB two-arm trial showed that yoga treatment is associated with reduced CIPN pain and reduced risk of falls compared to usual care control. We aim to increase cancer patients’ function and quality of life by identifying effective treatments to alleviate chemotherapy-related toxicities. The goal of the proposed project is to determine the efficacy of yoga in treating CIPN pain and improving function, as well as to improve sensory nerve recovery and reduce the risk of falls in cancer survivors suffering from moderate to severe CIPN pain. We will conduct a phase III, randomized, education and usual carecontrolled trial with 268 participants to: 1) determine the efficacy of an eight-week yoga treatment on CIPN symptoms among cancer survivors with moderate to severe CIPN pain; 2) evaluate the effect of yoga versus education control and usual care on improving flexibility and reducing the risk of falls; and 3) evaluate the effect of yoga versus education control and usual care on quality of life and sensory fiber functioning.


  • Zhi WI, Baser RE, Talukder D, Mei YZ, Harte SE, Bao T. Mechanistic and thermal characterization of acupuncture for chemotherapy-induced peripheral neuropathy as measured by quantitative sensory testing. Breast cancer research and treatment. 2023 Feb;197(3):535-545. Epub 2022 Dec 17. PMID: 36527520
  • Bao T, Baser R, Chen C, Weitzman M, Zhang YL, Seluzicki C, Li QS, Piulson L, Zhi WI. Health-Related Quality of Life in Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy: A Randomized Clinical Trial. The oncologist. 2021 Nov;26(11):e2070-e2078. Epub 2021 Aug 26. PMID: 34390283
  • Zhi WI, Baser RE, Kwon A, Chen C, Li SQ, Piulson L, Seluzicki C, Panageas KS, Harte SE, Mao JJ, Bao T. Characterization of chemotherapy-induced peripheral neuropathy using patient-reported outcomes and quantitative sensory testing. Breast cancer research and treatment. 2021 Apr;186(3):761-768. Epub 2021 Jan 28. PMID: 33507480
  • Zhi WI, Baser RE, Zhi LM, Talukder D, Li QS, Paul T, Patterson C, Piulson L, Seluzicki C, Galantino ML, Bao T. Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes. Cancer medicine. 2021 Aug;10(16):5456-5465. Epub 2021 Jul 2. PMID: 34213086