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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Santomasso, Bianca Denise

Sloan-Kettering Inst Can Research
United States

Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy 5R01CA293922-02 Monica Epstein, B.S.N., RN, OCN
Ligibel, Jennifer A.

Dana-Farber Cancer Inst
United States

Distance-based Exercise to preserve Function and prevENt Disability (DEFEND) 5U34CA293568-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Knoerl, Robert James

University Of Michigan At Ann Arbor
United States

Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors. 5R34CA286712-02 Goli Samimi, Ph.D., M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer 5R34CA289918-02 Brennan Streck, Ph.D., RN, M.P.H.
Lehto, Rebecca H

Henry Ford Health + Michigan State University Health Sciences
United States

Support for bereaved friend and family caregivers of cancer patients 1R03CA282943-01A1 Brennan Streck, Ph.D., RN, M.P.H.
Shiozawa, Yusuke

Wake Forest University Health Sciences
United States

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy 5R21CA297068-02 Rachel Altshuler, Ph.D.
Justilien, Verline

Mayo Clinic Jacksonville
United States

ECT2 Isoform Switch in Pancreatic Cancer. 5R21CA296671-02 Matthew Young, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 5R21CA296516-02 Rachel Altshuler, Ph.D.
Grossman, Douglas

Utah State Higher Education System--University Of Utah
United States

Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma 5R21CA289101-02 Nicholas Hodges, Ph.D.
Ah, Diane Marie Von

Ohio State University
United States

Cognitive Training for Cancer-related Cognitive Impairment: A Multi-Center Randomized Controlled Trial 5R01CA276222-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kang, Dongkyun

University Of Arizona
United States

Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy 1R01CA301271-01 Rachel Altshuler, Ph.D.
Clare, Susan E.

Northwestern University At Chicago
United States

Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype 1R21CA288676-01A1
Pistilli, Emidio Edward

West Virginia University
United States

Targeting Muscle Fatigability During Cachexia 5R01AR079445-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Greene, Nicholas Perry

University Of Arkansas At Fayetteville
United States

DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA 5R01AR075794-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chong, Catherine Daniela

Mayo Clinic Arizona
United States

Biomarker Signature to Predict the Persistence of Post-Traumatic Headache 5R33NS113315-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Status
Title Intervention Sponsor Status Sort descending
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors Biospecimen Collection, Questionnaire Administration SWOG Cancer Research Network Recruiting
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention University of Rochester Recruiting
Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment Behavioral Intervention, Electronic Health Record Review, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping NRG Oncology Recruiting
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity Carvedilol, Laboratory Biomarker Analysis, Patient Observation SWOG Cancer Research Network Recruiting
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy fractionated stereotactic radiosurgery (FSRS), single fraction stereotactic radiosurgery (SSRS) Wake Forest University Health Sciences Recruiting
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy, Quality-of-Life Assessment, Questionnaire Administration SWOG Cancer Research Network Recruiting
A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients Biospecimen Collection, Letermovir Children's Oncology Group Recruiting
Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma Biospecimen Collection, Calaspargase Pegol, Levocarnitine, Pegaspargase, Quality-of-Life Assessment Children's Oncology Group Recruiting