Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
SWOG Cancer Research Network
Status
Recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT05642611
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression. Taxane chemotherapy drugs, such as paclitaxel or docetaxel, can cause a nerve disorder called peripheral neuropathy, which can cause numbness, tingling, or pain in the arms and legs. The 3 study approaches will use a device, called the Paxman Limb Cryocompression System, made of wraps that cool and/or compress the arms and legs. This study may help researchers determine if any of the study approaches are able to prevent taxane chemotherapy from causing peripheral neuropathy.
Intervention
Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy, Quality-of-Life Assessment, Questionnaire Administration
Condition
Malignant Solid Neoplasm
Investigators
Melissa K Accordino, Katherine Pennington, MD, Rajesh Bajaj, Bernard Tawfik, Eleonora Teplinsky, Isaac Alwine, Christa Braun-Inglis, Shahzad Siddique, Dawn M. Severson, Ellen M. Smith, Kathleen J. Yost, Arvinda Padmanabhan, Rahul Seth, William J. Irvin, Demetria Smith-Graziani, Nicholas DiBella, Vinay K. Gudena, Julie R. Nangia, Praveen Vashist, Bolanle Gbadamosi, Stephanie L. Graff, Lauren Nye, Site Public Contact