Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name Sort descending	PI Organization	Title	Grant Number	Program Official
Kelleher, Sarah	Duke University United States	Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients	5R01CA291888-02	Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah	Duke University United States	Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings	5R21CA273832-02	Brennan Streck, Ph.D., RN, M.P.H.
Khasabov, Sergey G	University Of Minnesota United States	Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling	5R01CA263777-05	Rachel Altshuler, Ph.D.
Kleckner, Amber Simmons	University Of Maryland Baltimore United States	Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies	5R01CA284082-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Knoerl, Robert James	University Of Michigan At Ann Arbor United States	Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.	5R34CA286712-02	Goli Samimi, Ph.D., M.P.H.
Kober, Kord Michael	University Of California, San Francisco United States	An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach	5R37CA233774-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kolb, Noah Allan	University Of Vermont & St Agric College United States	Remote Monitoring of Management of Chemotherapy induced Peripheral Neuropathy	5R01CA247517-05	Brennan Streck, Ph.D., RN, M.P.H.
Kroetz, Deanna L	Ohio State University United States	Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity	5R01CA261068-06	Rachel Altshuler, Ph.D.
Lee, Richard T	Beckman Research Institute/City Of Hope United States	A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy	1R21CA260447-01A1	Rachel Altshuler, Ph.D.
Lehto, Rebecca H	Henry Ford Health + Michigan State University Health Sciences United States	Support for bereaved friend and family caregivers of cancer patients	1R03CA282943-01A1	Brennan Streck, Ph.D., RN, M.P.H.
Lesch, Bluma J	Yale University United States	Defining signatures of epigenetic sensitization to lung cancer in a mouse model	5R21CA288677-02	Guillermo Marquez, Ph.D.
Li, Feng	University Of California Los Angeles United States	Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.	5R21CA283665-02	Guillermo Marquez, Ph.D.
Ligibel, Jennifer A.	Dana-Farber Cancer Inst United States	Distance-based Exercise to preserve Function and prevENt Disability (DEFEND)	5U34CA293568-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Lindau, Stacy Tessler	University Of Chicago United States	Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy	5R01CA281301-03	Marjorie Perloff, M.D.
Mahan, Kristin Eckel	University Of Texas Hlth Sci Ctr Houston United States	Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain	1R21CA292148-01	John Clifford, Ph.D.

Clinical Trials

Title Sort descending	Intervention	Sponsor	Status
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors	Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer	Androgen deprivation therapy, Flibanserin 100 MG, Placebo	Andrew McDonald	Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	Laboratory Biomarker Analysis, Questionnaire Administration	Children's Oncology Group	Active, not recruiting
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial	Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention	University of Rochester	Recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors	Aerobic Exercise Training, Attention Control	University of Alabama at Birmingham	Active, not recruiting
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care	Haloperidol, Lorazepam, Placebo, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Active, not recruiting
High-Dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients	Biospecimen Collection, D Vitamin, Dual X-ray Absorptiometry, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	University of Rochester NCORP Research Base	Recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors	Biospecimen Collection, Questionnaire Administration	SWOG Cancer Research Network	Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer	Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping	NRG Oncology	Recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials	Questionnaires	Eastern Cooperative Oncology Group	Recruiting