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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Sort descending Grant Number Program Official
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.
Melemedjian, Ohannes Kevork

University Of Maryland Baltimore
United States

Identification of novel targets for the treatment of chemotherapy-induced painful peripheral neuropathy 4R01CA249939-02 Rachel Altshuler, Ph.D.
Plas, Ellen Van Der

Arkansas Children'S Hospital Res Inst
United States

Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia 5R37CA266135-04 Asad Umar, D.V.M., Ph.D.
Infante, Rodney E

Ut Southwestern Medical Center
United States

Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia 3R01CA266900-04S1 Marjorie Perloff, M.D.
Gonzalez, Brian D

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment 5R01CA287666-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.
Shelby, Rebecca A

Duke University
United States

Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention 1R21CA301298-01 Goli Samimi, Ph.D., M.P.H.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 5R21CA296516-02 Rachel Altshuler, Ph.D.
Kelleher, Sarah

Duke University
United States

Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings 5R21CA273832-02 Brennan Streck, Ph.D., RN, M.P.H.
Hall, Daniel Lee

Massachusetts General Hospital
United States

Innovating CBT-I for Cancer Survivors: An Optimization Trial 5R21CA279248-02
Eldridge, Ronald C

Emory University
United States

Integrative Multi-Omics of Metabolomics and Epigenetics to Explore thePathophysiology of Cachexia and Survival in Head and Neck SquamousCell Carcinoma 1R03CA304028-01 Marjorie Perloff, M.D.
Yu, Anthony Francis

Sloan-Kettering Inst Can Research
United States

Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial 5R37CA273923-03 Eileen Dimond, R.N., M.S.
Bartolini, Francesca

Columbia University Health Sciences
United States

Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN 5R01CA279401-02 Rachel Altshuler, Ph.D.
Staff, Nathan P

Mayo Clinic Rochester
United States

Investigating the role of MAP2 in chemotherapy-induced peripheral neurotoxicity 5R01CA275870-04 Rachel Altshuler, Ph.D.
Clare, Susan E.

Northwestern University At Chicago
United States

Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype 1R21CA288676-01A1

Clinical Trials

Status
Title Intervention Sponsor Status
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention University of Rochester Recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors Aerobic Exercise Training, Attention Control University of Alabama at Birmingham Active, not recruiting
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care Haloperidol, Lorazepam, Placebo, Quality-of-Life Assessment, Questionnaire Administration M.D. Anderson Cancer Center Active, not recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors Biospecimen Collection, Questionnaire Administration SWOG Cancer Research Network Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping NRG Oncology Recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials Questionnaires Eastern Cooperative Oncology Group Recruiting
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making Usual Care, Web-based decision aid Alliance for Clinical Trials in Oncology Active, not recruiting
IVIG for Infection Prevention After CAR-T-Cell Therapy Anti-CD19 CAR T Cells Preparation, Biospecimen Collection, Electronic Health Record Review, Immune Globulin Infusion (Human), 10% Solution, Saline, Survey Administration Fred Hutchinson Cancer Center Recruiting
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Lactobacillus plantarum strain 299, Lactobacillus plantarum strain 299v, Placebo Administration Children's Oncology Group Active, not recruiting
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula Biospecimen Collection, Distal Pancreatectomy, Lanreotide, Questionnaire Administration, Saline SWOG Cancer Research Network Recruiting