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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official Sort descending
Kroetz, Deanna L

Ohio State University
United States

Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity 5R01CA261068-06 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 5R21CA296516-02 Rachel Altshuler, Ph.D.
Buczynski, Matthew Wallace

Virginia Polytechnic Inst And St Univ
United States

Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathy 5R01CA284075-03 Rachel Altshuler, Ph.D.
Acharya, Munjal M

University Of California-Irvine
United States

Stem cell-derived exosomes to ameliorate chemobrain 5R01CA262213-03 Rachel Altshuler, Ph.D.
Staff, Nathan P

Mayo Clinic Rochester
United States

Investigating the role of MAP2 in chemotherapy-induced peripheral neurotoxicity 5R01CA275870-04 Rachel Altshuler, Ph.D.
Kang, Dongkyun

University Of Arizona
United States

Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy 1R01CA301271-01 Rachel Altshuler, Ph.D.
Paus, Ralf

University Of Miami School Of Medicine
United States

Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia 1R21CA277418-01A1 Rachel Altshuler, Ph.D.
Ross, Stephen

New York University School Of Medicine
United States

Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress 5R01CA268521-04 Rachel Altshuler, Ph.D.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Bartolini, Francesca

Columbia University Health Sciences
United States

Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN 5R01CA279401-02 Rachel Altshuler, Ph.D.
Afshar-Kharghan, Vahid

University Of Tx Md Anderson Can Ctr
United States

Novel Biomarkers Predicting Blood Clots in Ovarian Cancer 5R01CA275762-03 Rachel Altshuler, Ph.D.
Hu, Shuiying

Ohio State University
United States

Targeting neuronal transport to ameliorate vincristine neurotoxicity 5R01CA272254-03 Rachel Altshuler, Ph.D.
Brinkman, Tara M

St. Jude Children'S Research Hospital
United States

Culturally adapted mobile treatment of chronic pain in adolescent survivors of pediatric bone sarcoma 4R33CA280978-02 Rachel Altshuler, Ph.D.
Lee, Richard T

Beckman Research Institute/City Of Hope
United States

A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy 1R21CA260447-01A1 Rachel Altshuler, Ph.D.
Khasabov, Sergey G

University Of Minnesota
United States

Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling 5R01CA263777-05 Rachel Altshuler, Ph.D.

Clinical Trials

Status
Title Intervention Sponsor Status
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy Best Practice, Educational Intervention, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration, Text Message-based Navigation Intervention Alliance for Clinical Trials in Oncology Active, not recruiting
An Internet-based Program to Help Cancer Survivors Manage Pain Internet-based pain coping skills program Wake Forest University Health Sciences Recruiting
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics Non-interventional Study Wake Forest University Health Sciences Recruiting
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Behavioral Intervention, Compliance Monitoring, Laboratory Biomarker Analysis, Mercaptopurine, Questionnaire Administration, Standard Follow-Up Care Children's Oncology Group Active, not recruiting
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy University of Rochester NCORP Research Base Enrolling by invitation
Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection Axillary Lymph Node Dissection, Isosulfan Blue, Mapping, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Active, not recruiting
Cancer and Blood Pressure Management, CARISMA Study Best Practice, Blood Pressure Measurement, Clinical Management, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors Arm 1: Computerized Cognitive Training-Global Stimulation Games, Arm 2: Computerized Cognitive Training-Neuroplasticity Games NRG Oncology Recruiting
Communication About Sexual Health in Gynecologic Cancer Sexual Health Resources, Starting the Conversation Fox Chase Cancer Center Recruiting