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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Xu, Chunhui

Emory University
United States

High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes 1R21CA285254-01A1 Eileen Dimond, R.N., M.S.
Lesch, Bluma J

Yale University
United States

Defining signatures of epigenetic sensitization to lung cancer in a mouse model 5R21CA288677-02 Guillermo Marquez, Ph.D.
Mahan, Kristin Eckel

University Of Texas Hlth Sci Ctr Houston
United States

Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain 1R21CA292148-01 John Clifford, Ph.D.
Yang, Qing

University Of Texas Med Br Galveston
United States

The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy 5R01CA273001-02 Rachel Altshuler, Ph.D.
Schaverien, Mark V

University Of Tx Md Anderson Can Ctr
United States

Lymphedema Prevention Through Immediate Lymphatic Reconstruction 5R01CA292908-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Rini, Christine

Northwestern University At Chicago
United States

Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients 5R01CA292116-02 Brennan Streck, Ph.D., RN, M.P.H.
Winger, Joseph Giles

Duke University
United States

Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer 5R01CA291768-02 Brennan Streck, Ph.D., RN, M.P.H.
Flynn, Kathryn E

Medical College Of Wisconsin
United States

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM) 5R01CA285925-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Reb, Anne

Beckman Research Institute/City Of Hope
United States

A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer 1R21CA293326-01 Brennan Streck, Ph.D., RN, M.P.H.
Gonzalez, Brian D

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment 5R01CA287666-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Bartolini, Francesca

Columbia University Health Sciences
United States

Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN 5R01CA279401-02 Rachel Altshuler, Ph.D.
Marker, Ryan J

University Of Colorado Denver
United States

Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation 5R01CA292482-02 Goli Samimi, Ph.D., M.P.H.
Kleckner, Amber Simmons

University Of Maryland Baltimore
United States

Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies 5R01CA284082-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kelleher, Sarah

Duke University
United States

Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients 5R01CA291888-02 Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Status
Title Sort ascending Intervention Sponsor Status
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Lactobacillus plantarum strain 299, Lactobacillus plantarum strain 299v, Placebo Administration Children's Oncology Group Active, not recruiting
IVIG for Infection Prevention After CAR-T-Cell Therapy Anti-CD19 CAR T Cells Preparation, Biospecimen Collection, Electronic Health Record Review, Immune Globulin Infusion (Human), 10% Solution, Saline, Survey Administration Fred Hutchinson Cancer Center Recruiting
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making Usual Care, Web-based decision aid Alliance for Clinical Trials in Oncology Active, not recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials Questionnaires Eastern Cooperative Oncology Group Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping NRG Oncology Recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors Biospecimen Collection, Questionnaire Administration SWOG Cancer Research Network Recruiting
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care Haloperidol, Lorazepam, Placebo, Quality-of-Life Assessment, Questionnaire Administration M.D. Anderson Cancer Center Active, not recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors Aerobic Exercise Training, Attention Control University of Alabama at Birmingham Active, not recruiting
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention University of Rochester Recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Laboratory Biomarker Analysis, Questionnaire Administration Children's Oncology Group Active, not recruiting