Supported Projects

Supported Approaches

PREVENT supports these approaches to prevention:

  • Immunoprevention (e.g., vaccines for cancers associated or not associated with infectious agents, immunomodulatory agents)
  • Chemoprevention (e.g., novel mechanisms, novel agents, anti-inflammatory approaches, drug repurposing, toxicity reduction strategies by dose and scheduling optimization, alternative routes of drug administration or combination regimens)
  • Clinically translatable biomarkers of tumor progression and/or prevention efficacy

PREVENT Cycles 1 through 24

A total of 132 projects have been implemented: 79 chemoprevention projects, 44 immunoprevention projects, and 9 biomarker projects.  There are a total of 35 OPEN projects 97 COMPLETED projects.

Open Projects

Jump to:  Bladder | Blood | Breast | Colon | Liver | Lung | Mesothelium | Ovary | Pancreas | Prostate | Skin

Bladder

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention Prevention of Urinary Bladder Cancer with Two "Clinically-Ready" Agents (Everolimus and Naproxen) When Administered in Combination Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 75N91019D00020-0-759102000003-1
Chemoprevention Evaluation of Two Different Classes of compounds (STAT3 Inhibitors and SERMs) for the Prevention of Urinary Bladder Cancer Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 75N91019D00020-0-759102000005-1
Chemoprevention Bladder Cancer Chemoprevention Using AR Inhibitor Apalutamide Madka, Venkateshwar, Ph.D. University of Oklahoma Health Sciences 75N91019D00020-0-759102200002-1

Blood

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Immunoprevention Targeting DKK1 with a DNA vaccine to Prevent Development of Multiple Myeloma Yi, Qing, M.D., Ph.D. Houston Methodist Research Institute 75N91019D00021-0-759102300002-1

Breast

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention Use of Rosemary Extract/Carnosic Acid for Prevention of Ductal Carcinoma in situ Behbod, Fariba, Phar.D., Ph.D. University of Kansas Medical Center 75N91019D00016-0-759102000001-1
Chemoprevention Pre-clinical Assessment and IND for AFPep: Prevention of Breast Cancer Andersen, Thomas T., Ph.D. Albany Medical College 75N91019D00012-0-759102100001-1
Chemoprevention Targeting the PARP Pathway for the Prevention of Breast Cancer Brown, Powel H., M.D., Ph.D. MD Anderson Cancer Center, University of Texas 75N91019D00021-0-759102200001-1
Immunoprevention A Novel Multi-antigen Vaccine (TNBCvax) to Prevent Triple Negative Breast Cancer You, Ming, M.D., Ph.D. Houston Methodist Research Institute 75N91019D00020-0-759102100003-1
Immunoprevention A Multi-antigen Vaccine for the Primary Prevention of Breast Cancer Knutson, Keith, Ph.D. Mayo Clinic, Jacksonville FL N/A

Colon

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention LFA-9 (mPGES-1/5-LOX inhibitor): Preclinical Studies to Support a Clinical Trial Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201500024I-0-26100005-1
Chemoprevention TP-252: A Longer Acting Eicosapentaenoic Acid (EPA) Analogue for Colorectal Cancer Chemoprevention Rosenberg, Daniel W., Ph.D. University of Connecticut School of Medicine 75N91019D00019-0-759101900132-1
Chemoprevention Preventing Colorectal Cancer Using TRAIL Inducing ONC201 Alone or in Combination with NSAID Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 75N91019D00020-0-759102000004-2
Chemoprevention Targeting STAT3 to Prevent Colorectal Cancer Secondary to Inflammatory Bowel Disease Tweardy, David J., M.D. MD Anderson Cancer Center, University of Texas 75N91019D00021-0-759102100002-1
Chemoprevention Next Generation GP130/IL-6/STAT3 Inhibitors for the Prevention of Colitis-associated Colorectal Cancer Clapper, Margie L., Ph.D. Fox Chase Cancer Center 75N91019D00022-0-759102200002-1
Chemoprevention Microbial metabolite mimicry, a nano-drug for Colon cancer prevention Wan, Yu Jui Yvonne., Ph.D. University of California, Davis 75N91019D00022-0-759102200003-1
Chemoprevention Colorectal Cancer (CRC) Prevention by Urolithin A in Rodent CRC models Rosenberg, Daniel W., Ph.D. University of Connecticut School of Medicine 75N91019D00022-0-759102300001-1
Chemoprevention Colorectal Cancer (CRC) Prevention by TPST-1495 in PIRC rat model Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 75N91019D00020-0-759102300001-1
Immunoprevention Manufacture of a Vaccine Targeting Frame-Shift Mutations Characteristic of Tumors with Microsatellite Instability Lipkin, Steven M., M.D., Ph.D., F.A.C.M.G. Weill Cornell Medicine 75N91019D00025-0-759101900130-1
Immunoprevention Vaccines Against Fusobacterium for FAP- and Lynch Syndrome-associated Colorectal Cancer Immunoprevention Lipkin, Steven M., M.D., Ph.D., F.A.C.M.G. Weill Cornell Medicine 75N91019D00022-0-759102200001-1
Immunoprevention Further development of iPSC-based vaccine for Colon cancer prevention Wu, Joseph, M.D., Ph.D. Stanford University 75N91019D00021-0-759102300001-1

Liver

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention Targeting STAT3 to Prevent Hepatocellular Carcinoma (HCC) Associated with Non-Alcoholic Steatohepatitis (NASH) Tweardy, David J., M.D. MD Anderson Cancer Center 75N91019D00021-0-759102000001-1

Lung

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention Preventing Lung Cancer by Targeting Activated STAT3 Siegfried, Jill M.D., Ph.D. University of Minnesota 75N91019D00022-0-759102000001-1
Chemoprevention Chemoprevention with mitochondria-targeted honokiol in mouse models of lung cancer: adenocarcinoma and squamous cell carcinoma You, Ming, M.D., Ph.D. Houston Methodist Research Institute 75N91019D00020-0-759102200004-1
Chemoprevention Preventing Lung Adenocarcinoma (LUAD) using TRAIL inducing agent, ONC201 Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 75N91019D00020-0-759102200003-1
Chemoprevention Targeting STAT3 to Prevent Non-small Cell Lung Cancer (NSCLC) in Patients with Chronic Obstructive Pulmonary Disease (COPD) Tweardy, David J., M.D. Univ Texas MD Anderson 75N91019D00021-0-759102000001-1
Immunoprevention Lowering the risk of lung and other cancers in high-risk smokers using an anti-nicotine human mAb for smoking cessation Kalnik, Matthew W., Ph.D. Antidote Therapeutics, Inc. N/A
Immunoprevention Potentiation of a Multi-antigen Lung Cancer Vaccine with CA170 You, Ming, M.D., Ph.D. Houston Methodist Research Institute 75N91019D00020-0-759102100001-1
Immunoprevention Nicotine Reduction Therapy Using the Human Monoclonal Antibody, ATI-1013 Kalnik, Matthew W., Ph.D. Antidote Therapeutics, Inc. 75N91019D00013-0-75N91023F00001

Mesothelium

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention Sulforaphane for the prevention of malignant mesothelioma Testa, Joseph, Ph.D. Fox Chase Cancer Center 75N91019D00022-0-759102300003-1

Ovary

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Immunoprevention Primary Immunoprevention of Human Epithelial Ovarian Carcinoma (EOC) Tuohy, Vincent K, Ph.D. Cleveland Clinic 75N91019D00020-0-759102100002-1

Pancreas

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Biomarkers Evaluation of Real-time Metabolic Imaging Biomarkers for Detection of Pancreatic Premalignant Lesions Bhattacharya, Pratip, Ph.D. MD Anderson  75N91019D00021-0-759102100003-1
Immunoprevention Targeting the A2B Adenosine Receptor for Immunoprevention of Pancreatic Cancer Bailey, Jennifer M., Ph.D. University of Texas Health Science Center Houston 75N91019D00021-0-759102300003-1

Prostate

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Immunoprevention Preclinical Development of an RNA Vaccine for Immunoprevention of Prostate Cancer Erasmus, Jesse, Ph.D. HDT Bio Corp 75N91019D00012-0-759102000001-1

Skin

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK
Chemoprevention A Dual AKT/PDPK1 Inhibitor for Actinic Keratosis and Skin Cancer Prevention Kirkpatrick, Lynn D, Ph.D. PHusis Therapeutics 261201500026I-0-26100003-1
Chemoprevention Topical Resatorvid for Nonmelanoma Skin Cancer Prevention Curiel, Clara, M.D. University of Arizona 75N91019D00013-0-759102000001-1
Completed Projects

Jump to:  Bladder | Breast | Cervix | Colon | Endometrium | Esophagus | Liver | Lung | Mesothelium | Oral/Head And Neck | Ovary | Pancreas | Prostate | Other Cancers, Solid Tumors

Bladder

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Evaluation of Agents/Protocols that Inhibit Two Major Pathways Involved in Human Urinary Bladder Cancer (PI3K, EGFR) and Protocols to Reduce Their Toxicity Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201500036I-0-26100002-1  
Chemoprevention Prevention of Urinary Bladder Cancer with Two Clinically-Ready Agents (Everolimus and Naproxen) When Administered in Combination Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201500036I-0-26100008-1 75N91019D00020-0-759102000003-1
Chemoprevention Evaluation of Two Different Classes of Compounds (STAT3 Inhibitors and SERM.S.) for Prevention of Urinary Bladder Cancers Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 75N91019D00019-0-759101900130-1 75N91019D00020-0-759102000005-1
Chemoprevention Preclinical Development of Newly Formulated Chemopreventive Agent 4-methylumbelliferone Prodrug Lokeshwar, Vinata, Ph.D. Augusta University 261201500036I-0-26100010-1  
Immunoprevention Multi-antigen Vaccines for the Primary and Secondary Prevention of Bladder Cancer Disis, Mary (Nora) L., M.D., M.S. University of Washington 261201500036I-0-26100006-1 261201500036I-0-26100011-1
Immunoprevention Further Development of Multi-Antigen Vaccines for the Primary and Secondary Prevention of Bladder Cancer Disis, Mary (Nora) L., M.D., M.S. University of Washington 261201500036I-0-26100011-1  

Breast

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Biomarker Chemopreventive Effects in Both Standard Chow Diets and High Fat Diets of Known Positive and Negative Chemopreventive Agents Employing Both High Risk (But Histologically Normal) Mammary Epithelium and Mammary Cancers Including Correlative Biomarkers Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham N/A  
Biomarker Blood-based Biomarkers of Obesity-Induced Breast Inflammation Dannenberg, Andrew J., M.D. Weill Cornell Medicine 261201200018I-0-26100003-1  
Chemoprevention Large Scale Synthesis of 9-cis-UAB30 to Support Translational Development of this Novel Chemopreventive Rexinoid Muccio, Donald D., Ph.D. University of Alabama at Birmingham N/A  
Chemoprevention Evaluation of GLG-302, a STAT3 Antagonist, in the Prevention of Mammary Cancer Lovell, Michael W., Ph.D. GLG Pharma, LLC 261201200021I-0-26100004-1 261201500036I-0-26100003-1
Chemoprevention Evaluation of the Cancer Prevention Efficacy of GLG-302 Lovell, Michael W., Ph.D. GLG Pharma, LLC 261201500036I-0-26100003-1 261201500036I-0-26100007-1
Chemoprevention Evaluation of STAT3 Antagonists in the Prevention of Mammary Cancer Lovell, Michael W., Ph.D. GLG Pharma, LLC 261201500036I-0-26100007-1  
Chemoprevention Efficacy of Metformin in the Methylnitrosourea-induced Model of ER+ Mammary Carcinogenesis when Animals are Placed on Different Diets: Standard Diet, High Fat Diet, and High Fructose Diet Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201200021I-0-26100005-1  
Chemoprevention Evaluation of the Prevention by ACTOPLUS/MET (Pioglitazone and Metformin) of ER+ and ER- Mammary Cancers Occurring in Rodents on a High-Fat Diet Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201200021I-0-26100006-1  
Chemoprevention Effect of Bazedoxifene Either Alone or in Combination with an Aromatase Inhibitor or Conjugated Estrogens (CE) in the Prevention of Mammary Cancers Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201200021I-0-26100007-1  
Chemoprevention Support for Endoxifen Gel Clinical Development Khan, Seema A., M.D. Northwestern University 261201500024I-0-26100002-1  
Chemoprevention Examination of HJC0152 as a Putative Modulator of Glucose and Energy Metabolism for Mammary Cancer Shen, Qiang, M.D., Ph.D. MD Anderson Cancer Center 261201500018I-0-26100002-1  
Chemoprevention Evaluation of “Clinical-Ready” Agents (Bazedoxifene and Lapatinib) in Combination for the Prevention of ER+ and ER- Mammary Cancers Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201500036I-0-26100005-1  
Chemoprevention Targeted casein kinase 1δ (CK1δ) inhibition as a breast cancer prevention strategy Aldaz, C. Marcelo, M.D., Ph.D. MD Anderson Cancer Center 261201500018I-0-26100005-1  
Chemoprevention Targeting the mTOR Pathway for the Prevention of Breast Cancer Brown, Powel H., M.D., Ph.D. MD Anderson Cancer Center 261201500018I-0-26100006-1 75N91019D00021-0-759102200001-1
Chemoprevention RANK Ligand Inhibition: A Potential Chemoprevention Strategy for Women at High Genetic Risk of Breast Cancer Lindeman, Geoffrey, Ph.D., F.R.A.C.P., M.B.B.S. Walter and Eliza Hall Institute of Medical Research 261201500018I-0-26100009-1  
Chemoprevention Targeting the RXR Pathway for the Prevention of Triple Negative Breast Cancer MazuM.D.ar, Abhijit, Ph.D. MD Anderson Cancer Center, University of Texas 261201500018I-0-26100008-1  
Immunoprevention Efficacy of a Multi-Antigen Vaccine in the Prevention of MNU-induced Mammary Cancers ER Positive in Female SD Rats Grubbs, Clinton J., Ph.D. University of Alabama at Birmingham 261201200021I-0-26100002-1  
Immunoprevention AAV1-Plac1 Vaccine Platform for Cancer Prevention Glazer, Robert I., Ph.D. Georgetown University 261201200018I-0-26100002-1  
Immunoprevention Development of a Multi-antigen, Multi-peptide Vaccine Based on Gene Expression Information to Prevent Triple Negative Breast Cancer (TNBC) in a Mouse Model You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100007-1 261201500037I-0-26100008-1
Immunoprevention Further Development of Multi-Antigen, Multi-Peptide Vaccine based on Gene Expression Information to Prevent Triple Negative Breast Cancer in a Mouse Model You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100008-1 75N91019D00020-0-759102100003-1
Immunoprevention Evaluating Whether Concurrent 9cUAB30 Rexinoic Acid Receptor Agonist and HER2-IGFBP2-IGF1R Vaccine Can Enhance Treatment of Ductal Carcinoma In Situ and Prevention of Invasive Breast Cancer Stanton, Sasha E, M.D., Ph.D. University of Washington 261201500036I-0-26100009-2  
Immunoprevention Cancer Prevention by Vaccination Against Induced Antigens Hanash, Samir M., M.D., Ph.D. MD Anderson Cancer Center 75N91019D00021-0-759101900132-1  

Cervix

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Nonclinical Safety, Toxicokinetic, and Stability Evaluation of Bio response Diindolylmethane Vaginal Cream for Topical Treatment of Cervical Intraepithelial Neoplasia (CIN) Zeligs, Michael, M.D. BioResponse, LLC 261201200025I-0-26100002-1  
Immunoprevention Safety Evaluation of pNGVL4a-CRT-E6E7L2 (detox) Recombinant DNA Vaccine in Mice Roden, Richard B. S., Ph.D. Johns Hopkins 261201200026I-0-26100002-1  
Immunoprevention Support for HPV16L1/RG1 Chimeric Virus-Like Particle Vaccine Clinical Development Kirnbauer, Reinhard, M.D. Medical University Vienna  261201500026I-0-26100002-1 75N91019D00027-0-759102100001-1
Immunoprevention cGMP Re-Supply of HPV16L1/16RG1  Kirnbauer, Reinhard, M.D. Medical University Vienna  75N91019D00027-0-759102100001-1  
Immunoprevention cGMP Production of a Chimeric Virus-Like Particle Vaccine (RG1-VLP) for Prevention of HPV-Associated Cancers Kirnbauer, Reinhard, M.D. Medical University Vienna  N/A 261201500026I-0-26100002-1

Colon

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Biomarker Effect of a Chemopreventive Agent on the Fecal Metabolite Profile in Intestinal Neoplasia Gross, Steven, Ph.D. Cornell University N/A  
Biomarker Molecular Heterogeneity of Inflammation and Growth Factor Pathways in Sporadic and Syndromic Colon Cancers: Implications for Prevention and Therapeutic Trials Bernard, Philip S., M.D. University of Utah 261201200013I-0-26100008-1  
Chemoprevention Preclinical Development of mPGES-1 and 5-LOX Selective Inhibitors for Chemoprevention Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200020I-0-26100004-1 261201500024I-0-26100005-1
Chemoprevention Efficacy of Aspirin and Naproxen (Short-term Frequent Dosing) in Colorectal Cancer Models Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200020I-0-26100002-1  
Chemoprevention Combination of Aspirin and Omeprazole for Colorectal Cancer Chemoprevention Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200020I-0-26100003-1  
Chemoprevention NSAID Chemoprevention in Colorectal Cancer Fishel, Richard, Ph.D. Ohio State University 261201200020I-0-26100005-1  
Chemoprevention Efficacy of Eldecalcitol (ED-71) in Colorectal Cancer Prevention in ApcMin Mouse Model Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200015I-0-26100005-1  
Chemoprevention Combination of Aspirin or Naproxen with Omeprazole for Colorectal Cancer Chemoprevention with Clinically Relevant Doses Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201500038I-0-26100003-1  
Chemoprevention Prevention of Colorectal Cancer by ONC201 El-Deiry, Wafik, M.D., Ph.D., F.A.C.P. Fox Chase Cancer Center 261201500038I-0-26100006-1  
Chemoprevention Determination of Dosing Regimens of Erlotinib in Combination with Sulindac for Prevention of Colorectal Cancer While Reducing Agent Toxicity. Dashwood, Roderick H., Ph.D., M.S. Texas A&M University 261201500018I-0-26100004-1 75N91019D00021-0-759101900130-1
Chemoprevention Chemoprevention of Colorectal Cancer with Olmesartan Medoxomil Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201500038I-0-26100011-2  
Chemoprevention Optimization of Dosing Regimens of Sulindac in Combination with Erlotinib for Small Intestinal and Colon Cancer Prevention Dashwood, Roderick H., Ph.D., M.S. Texas A&M University 75N91019D00021-0-759101900130-1  
Chemoprevention Preventing FAP-CRC using rLon Protease in PIRC Rat Model Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 75N91019D00020-0-759102200001-1  
Chemoprevention A Novel Non-COX Inhibitory Sulindac Derivative for Colorectal Cancer Chemoprevention with Selective PDE10 and Wnt/β-Catenin Inhibitory Activity  Piazza, Gary A., Ph.D. University of South Alabama Mitchell Cancer Institute 261201500032I-0-26100003-1  
Immunoprevention Characterization of Potential Antigens for Immunization Against Colon Cancer and Testing Multivalent Tumor Vaccines in Min Mice Broussard, Elizabeth, M.D. University of Washington 261201200013I-0-26100003-1  
Immunoprevention Testing of Combination Immuno- and Chemoprevention Strategies for Lynch Syndrome Lipkin, Steven M., M.D., Ph.D., F.A.C.M.G. Weill Cornell Medicine 261201500039I-0-26100003-1 261201500039I-0-26100005-1
Immunoprevention Immunogenic effects of NSAIDs with and without a vaccine in colon cancer prevention Disis, Mary (Nora) L., M.D., M.S. University of Washington 261201500036I-0-26100004-1 75N91019D00019-0-759101900131-1
Immunoprevention Anti-Fusobacterium nucelatum Vaccine for Colorectal Cancer Immunoprevention Lipkin, Steven M., M.D., Ph.D., F.A.C.M.G. Weill Cornell Medicine 261201500039I-0-26100004-1 75N91019D00022-0-759102200001-1
Immunoprevention Further Development of Colovac, a Multi-antigen Multi-peptide Vaccine, for Colon Cancer Prevention Disis, Mary (Nora) L., M.D., M.S. University of Washington 75N91019D00019-0-759101900131-1  
Immunoprevention Frameshift peptide Vaccine for the Prevention of Lynch Syndrome-associated Gastrointestinal Cancer Lipkin, Steven M., M.D., Ph.D., F.A.C.M.G. Weill Cornell Medicine 261201500039I-0-26100005-1 75N91019D00025-0-759101900130-1
Immunoprevention Prevention of Colorectal Cancer with iPSC-based Vaccine  Wu, Joseph, M.D., Ph.D. Stanford University 75N91019D00021-0-759102100001-1 75N91019D00021-0-759102300001-1

Endometrium

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention cGMP NSC 721689 Production for IRB-approved and NCI-funded Clinical Trials Benbrook, Doris M., Ph.D. University of Oklahoma Health Sciences N/A  
Chemoprevention Chemoprevention of Endometrial Hyperplasia and its Transition to Endometrial Cancer with NSC 721689 Benbrook, Doris M., Ph.D. University of Oklahoma Health Sciences 261201500038I-0-26100008-1  

Esophagus

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Chemoprevention of Esophageal Cancer by Targeting Multiple Pathways in a Mouse Model of Barrett’s Esophagus Wang, Timothy C., M.D. Columbia University 261201500039I-0-26100002-1  

Liver

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Prevention of Hepatocellular Carcinoma (HCC) Associated with Non-Alcoholic Steatohepatitis (NASH) Beretta, Laura, Ph.D. MD Anderson Cancer Center 261201500018I-0-26100007-1  

Lung

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Biomarker Modulation of Cigarette Smoke-induced Alterations in microRNA Expression and Lung Tumors in Mice Treated with Aspirin and Naproxen De Flora, Silvio, M.D. University of Genoa 261201200015I-0-26100003-1 261201200015I-0-26100006-1
Biomarker Effects of Chemopreventive Agents on Biomarkers Related to Lung Tumorigenesis: Alterations in Normal Lung, “At Risk” Histologically Normal Lung and Lung Lesions You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201200015I-0-26100004-1  
Biomarker Examination of Exosomal miRNAs as Potential Biomarkers for Chemopreventive Efficacy in Mouse Models of Lung Squamous Cell Carcinoma You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100003-1  
Biomarker Modulation of miRNA Expression in Blood or Other Biological Fluids Compared with Tissue Levels in Mice Exposed to Cigarette Smoke and/or with NSAIDs Izzotti, Alberto, M.D., Ph.D. University of Genoa 261201200015I-0-26100006-1  
Chemoprevention In Vivo Evaluation of a Chemopreventive Agent, Ciclesonide, in Mouse Lung Tumor Model by Inhalation Sharma, Sheela, Ph.D., M.S. Integrated Laboratory SysteM.S., Inc. 261201200013I-0-26100002-1  
Chemoprevention Anti-inflammatory Effects of Fixed Dose Combination of Pioglitazone and Metformin for Lung Cancer Prevention Wattenberg, Lee W., M.D. University of Minnesota 261201200015I-0-26100002-1  
Chemoprevention Effects of Weekly or Intermittent Dosing Regimens of EGFR, MEK and PI3K Inhibitors in Mouse Models of Lung Cancer Wang, Yian, M.D., Ph.D. Washington University at St. Louis 261201200013I-0-26100007-2  
Chemoprevention Chemoprevention with Aerosolized Bexarotene in Mouse Models of All Three Major Subtypes of Lung Cancer: Adenocarcinoma, Squamous Cell Carcinoma and Small Cell Lung Cancer Wang, Yian, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201200020I-0-26100007-1 261201500024I-0-26100004-1
Chemoprevention Support for Aerosol Development of Bexarotene Wang, Yian, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500024I-0-26100004-1  
Chemoprevention Lung Cancer Chemoprevention by microRNA Delivery Izzotti, Alberto, M.D., Ph.D. University of Genoa 261201500037I-0-26100005-1 75N91019D00020-0-759101900130-1
Chemoprevention Chemoprevention with Aerosolized Let-7 microRNA in Mouse Models of Non-Small Cell Lung Cancer (Adenocarcinoma and Squamous Cell Carcinoma) You, Ming, M.D., Ph.D. Houston Methodist Research Institute (formerly at MCW) 75N91019D00020-0-759101900130-1  
Chemoprevention Repurposing of the Macrolide Antibiotic Clarithromycin for the Prevention of Lung and Breast Cancer Aldaz, C. Marcelo, M.D., Ph.D. MD Anderson Cancer Center 75N91019D00021-0-759101900131-1  
Immunoprevention Use of TERT Vaccine in Prevention of Lung Cancer in Animal Models You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201200013I-0-26100006-1 261201500037I-0-26100002-1
Immunoprevention Multi-Antigen Vaccine for Lung Cancer Prevention Disis, Mary (Nora) L., M.D., M.S. University of Washington 261201200013I-0-26100009-1  
Immunoprevention Development of Multiantigen Vaccines to Prevent the Development of Lung Adenocarcinomas Driven by either K-RAS or EGFR Oncoproteins in Mice You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100002-1 75N91019D00020-0-759102000002-1
Immunoprevention Rational Design and Development of a Multi-Antigen Multi-Peptide Vaccine Based on Genomic Information to Prevent Lung Cancer Initiation and Progression You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100004-1  
Immunoprevention EGFR and KRAS Vaccine to Prevent Lung Cancer You, Ming, M.D., Ph.D. Houston Methodist Research Institute (formerly at MCW) 75N91019D00020-0-759102000002-1  

Mesothelium

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Targeting the IL-6 Signaling Pathway as Chemopreventative Therapy for High-Risk Malignant Mesothelioma Populations Menges, Craig, Ph.D. Fox Chase Cancer Center 261201500032I-0-26100002-1 75N91019D00022-0-759102200002-1

Oral/Head And Neck

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Oral Cancer Chemoprevention by Inhibitors of Inducible Nitric Oxide Synthase (iNOS) McCormick, David L., Ph.D., D.A.B.T. IIT Research Institute 261201200016I-0-26100002-1  

Ovary

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Ovarian Cancer Chemoprevention Benbrook, Doris M., Ph.D. University of Oklahoma Health Sciences 261201500038I-0-26100002-1  
Chemoprevention Ovarian Cancer Chemoprevention Benbrook, Doris M., Ph.D. University of Oklahoma Health Sciences 261201500041I-0-26100002-1  
Immunoprevention Mesothelin Vaccination for the Prevention of Ovarian Cancer Scholler, Nathalie, M.D., Ph.D. SRI International 261201200014I-0-26100002-1 261201500041I-0-26100003-1
Immunoprevention Optimization and Further Development of Mesothelin Vaccine for the Prevention of Ovarian Cancer Scholler, Nathalie, M.D., Ph.D. SRI International 261201500041I-0-26100003-1  

Pancreas

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Targeting P2X7 Receptor Antagonists for Prevention of Pancreatic Cancer Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200013I-0-26100004-1  
Chemoprevention Targeting CCK2R for Pancreatic Cancer Prevention Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200020I-0-26100006-1  
Chemoprevention Preclinical Studies to Evaluate the Combination of Metformin and Aspirin for the Prevention of Pancreatic Cancer Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200013I-0-26100010-1  
Chemoprevention Optimization of GEM Models for High-Risk Cohorts of Human Pancreatic Cystadenomas, IPMNs and PanINs Progression to PDAC Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201500038I-0-26100004-1  
Immunoprevention Development of Muc1 Vaccine for the Prevention of Pancreatic Cancer Rao, Chinthalapally V., Ph.D. University of Oklahoma Health Sciences 261201200013I-0-26100005-1  
Immunoprevention Cancer Prevention by α-Enolase Vaccination Novelli, Francesco, M.D. University of Turin 261201500018I-0-26100003-1  
Immunoprevention Effect of a Multipeptide KRAS Vaccine in the Prevention of Pancreatic Cancer Driven by KRAS Oncoprotein You, Ming, M.D., Ph.D. Medical College of Wisconsin Cancer Center 261201500037I-0-26100006-1 75N91019D00020-0-759102000001-1
Immunoprevention Further Testing of a Multi-peptide KRAS Vaccine for Pancreatic Cancer Prevention You, Ming, M.D., Ph.D. Houston Methodist Research Institute (formerly at MCW) 75N91019D00020-0-759102000001-1  
Immunoprevention Preclinical Testing of CD73 Inhibitors for Pancreatic Cancer Immunoprevention Bailey, Jennifer M., Ph.D. University of Texas Health Science Center Houston 75N91019D00021-0-759102000002-1  

Prostate

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Chemoprevention Chemoprevention of Prostate Cancer via Estrogen Receptor β Agonists McCormick, David L., Ph.D., D.A.B.T. IIT Research Institute 261201200016I-0-26100003-1  
Chemoprevention Novel Androgen Receptor Antagonist-Mediated Chemoprevention of Prostate Cancer in Preclinical Model McCormick, David L., Ph.D., D.A.B.T. IIT Research Institute 261201500042I-0-26100002-1  
Chemoprevention Preclinical Evaluation of a New Lipid-Based SMEDDS BR-9001 Formulation Zeligs, Michael, M.D. BioResponse, LLC 261201500024I-0-26100003-1 261201500042I-0-26100003-1
Chemoprevention Preclinical Development of Chemopreventive agent 4-methylumbelliferone: Formulation Optimization  Lokeshwar, Vinata, Ph.D. Augusta University N/A 261201500036I-0-26100010-1
Chemoprevention Prostate Cancer Prevention by Aspirin and/or Other NSAIDs Bosland, Maarten C., DVS, Ph.D. University of Illinois 261201500038I-0-26100005-1  
Chemoprevention Preclinical Efficacy Evaluation of The Lipid-Based SMEDDS Formulation of DIM, BR-9001 Zeligs, Michael, M.D. BioResponse, LLC 261201500042I-0-26100003-1  

Other Cancers, Solid Tumors

Project Type Project Title Application Principal Investigator (PI) Applicant PI's Institution NIH_RePORT_LINK Follow-on Project if Applicable (NIH_RePORluT_LINK)
Immunoprevention A Polyvalent Vaccine Against Fusion Proteins Observed in Solid Tumors Jaffee, Elizabeth M., M.D. Johns Hopkins Kimmel Cancer Center 261201200018I-0-26100006-1  

Last modified: May 9, 2024