Key Activities

'Last Mile' Initiative Key Activities

NCI Cervical Cancer ‘Last Mile’ Initiative (LMI)

Facilitating discussions for regulatory approvals for self-collection

  • Reviewing evidence on self-collection to inform regulatory pathways
  • Facilitation of discussions between FDA and HPV assay manufacturers seeking approvals for self-collection approaches for primary HPV testing

Self-collection for HPV testing to Improve Cervical Cancer Prevention (SHIP) Trial

  • Nationwide multicenter clinical trial and associated studies
  • Independent evaluation of multiple self-collection devices and HPV assays for usability, acceptability, accuracy, and effectiveness to inform implementation

Disseminating evidence on self-collection to change and inform clinical practice

  • Partnerships with professional societies to update clinical practice guidelines after FDA approvals for self-collection
  • Creating publicly-accessible repository of resources on self-collection