Cancer Screening Research Network (CSRN)

Flowchart of the Cancer Screening Coordinating Communications CenterThe National Cancer Institute (NCI) is establishing a new Cancer Screening Research Network (CSRN) to conduct trials and studies specifically related to cancer screening. The network will be comprised of Accrual, Enrollment, and Screening Site (ACCESS) Hubs; a Statistics and Data Management Center (SDMC); and a Coordinating and Communication Center (CCC).

  • ACCESS Hubs will serve as organizations or groups of organizations that will recruit participants to CSRN trials and studies and participate in the scientific development and implementation of those trials and studies. 
     
  • The SDMC will provide statistical leadership to ensure effective design, conduct, and analysis of CSRN trials and studies, and will provide centralized data management, expertise, quality control, and reporting.
     
  • The CCC will coordinate all aspects of study operations and the development and implementation of communication activities, and will provide trial infrastructure, including management of meetings and maintaining protocol and network guideline-related information.

The CSRN will conduct rigorous, multi-center cancer screening trials and studies with large and diverse populations in a variety of health care settings with the ultimate goal of reducing cancer incidence and cancer-related morbidity and mortality. Cancer screening provides a unique opportunity to diagnose cancers and pre-cancerous lesions before symptoms develop. New emerging technologies, including Multi-Cancer Detection assays (MCDs), are rapidly coming forward for commercial availability, though a variety of challenges exist in the design and conduct of randomized controlled trials that evaluate MCD tests to screen for multiple different cancers. As an initial effort, the CSRN will develop a feasibility study, called a Vanguard study, to inform the future design of a platform trial to evaluate multiple different technologies for cancer screening in a flexible but rigorous manner. This study will pave the way for future large-scale clinical trials and other studies developed to assess a variety of cancer screening modalities.

The CSRN will use the NCI Clinical Trials Infrastructure, which includes a variety of integrated electronic systems, applications, and processes, which together facilitate the conduct of cancer clinical trials.

Preliminary Vanguard Study Design

The Preliminary Vanguard Study Design

Preliminary Design for Large-Scale Trial

The Preliminary Design for Large-Scale Trial

Pre-Application Webinars

The NCI Division of Cancer Prevention will hold pre-application interactive webinars for funding opportunities for the Cancer Screening Research Network (CSRN). The first webinar will provide an overview of the Network, and address all three grants. There will be three subsequent RFA-specific webinars. NCI staff will discuss the funding opportunities and answer questions from prospective applicants. Participants are asked to submit their questions ahead of time to CSRN@nih.gov by the Wednesday preceding the webinar of interest by 11:59 PM EST. Participation in the webinars is optional.

All CSRN Grants

(RFA-CA-23-020, RFA-CA-23-021, RFA-CA-23-022)
Date: Friday, December 9, 2022
Time: 1:00 pm ET
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RFA Specific Sessions

RFA-CA-23-021: NCI Cancer Screening Research Network: Statistics and Data Management Center
Date: Friday, December 16, 2022
Time: 11:00 am ET
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RFA-CA-23-022: NCI Cancer Screening Research Network: Coordinating and Communication Center (UG1 Clinical Trial Required)
Date: Friday, December 16, 2022
Time: 12:00 pm ET
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RFA-CA-23-020: NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub
Date: Friday, December 16, 2022
Time: 1:00 pm ET
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Presentations

Cancer Screening Research Network (CSRN)
Date: November 14, 2022

NCI Board of Scientific Advisors Presentation
Date: June 15, 2022

View all Presentations

Funding Opportunity Announcements

  • RFA-CA-23-020 Funding Opportunity Announcement for NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub (UG1 Clinical Trial Required)
     
  • RFA-CA-23-021 Funding Opportunity Announcement for NCI Cancer Screening Research Network: Statistics and Data Management Center (UG1 Clinical Trial Required)
     
  • RFA-CA-23-022 Funding Opportunity Announcement for NCI Cancer Screening Research Network: Coordinating and Communication Center (UG1 Clinical Trial Required)

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Questions and Answers

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