Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT)

The Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) is a collaborative research network with the overarching goal of discovering molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process in higher-risk populations. For the purpose of the funding opportunities that will support this discovery research initiative, cancer prevention is defined as primary prevention of cancer before the oncogenic process begins, while cancer interception refers to disruption of the oncogenic process during the precursor or precancer state or stage.

To achieve the program’s goal, CAP-IT research objectives are:

  • To identify and functionally validate targets that can be potentially exploited for cancer preventive or interceptive interventions specifically in higher-risk populations, by collaborating with the NCI and other programs with a research focus on molecular profiling of established precursor/precancer, early cancer, and/or oncogenic signaling pathways. The potentially exploitable cancer preventive or interceptive targets include oncogenic molecular targets and pathways, tumor immune microenvironment targets, and tumor-specific/tumor-associated antigens.
     
  • To discover innovative targeted agents through in vitro and in vivo efficacy evaluation and advance promising efficacious agents to the NCI's existing R&D pipeline for further development.

The CAP-IT network will be formed by the U54 Specialized Centers and one U24 Data and Resource Coordination Center.

Funding Opportunities

NCI-sponsored Funding Opportunity Announcements (FOAs) related to CAP-IT include:

  • Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Specialized Centers (U54 Clinical Trial Not Allowed) – expires October 8, 2021
    RFA-CA-21-038
  • Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Data and Resource Coordination Center (CAP-IT DRCC) (U24 Clinical Trial Not Allowed) – expires October 8, 2021
    RFA-CA-21-039

Pre-Application Webinar

NCI is holding a pre-application webinar for the CAP-IT FOAs. More details are available in the NIH Guide for Grants and Contracts, NOT-CA-21-097.

Register for webinar scheduled on August 16th, 2021 from 1:00 to 2:00 pm ET

Recordings and answers to frequently asked questions will be posted to this web page 2-3 weeks after the webinar for those who are not able to attend.