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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Sort descending Grant Number Program Official
Milbury, Kathrin

University Of Tx Md Anderson Can Ctr
United States

Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers 4R37CA231522-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Justilien, Verline

Mayo Clinic Jacksonville
United States

ECT2 Isoform Switch in Pancreatic Cancer. 5R21CA296671-02 Matthew Young, Ph.D.
Marker, Ryan J

University Of Colorado Denver
United States

Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation 5R01CA292482-02 Goli Samimi, Ph.D., M.P.H.
Penedo, Frank J

University Of Miami Coral Gables
United States

eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant Patients 4R33CA263335-03 Asad Umar, D.V.M., Ph.D.
Grossman, Douglas

Utah State Higher Education System--University Of Utah
United States

Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma 5R21CA289101-02 Nicholas Hodges, Ph.D.
Winger, Joseph Giles

Duke University
United States

Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer 5R01CA291768-02 Brennan Streck, Ph.D., RN, M.P.H.
Mao, Jun J

Sloan-Kettering Inst Can Research
United States

Enhanced Pain Coping in Cancer (EPIC) 5R01CA285746-02 Rachel Altshuler, Ph.D.
Nolan, Michael Warren

North Carolina State University Raleigh
United States

Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer 5R37CA248797-05 Asad Umar, D.V.M., Ph.D.
Zhu, Yong

Univ Of Arkansas For Med Scis
United States

Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection 1R21CA277412-01A1 Christos Patriotis, Ph.D., M.Sc.
Vijayvergia, Namrata

Research Inst Of Fox Chase Can Ctr
United States

Exploring the Neuroprotective Potential of CBD in Preventing Oxaliplatin-Induced Neuropathy: A Prospective Study 1R21CA292276-01A1 Rachel Altshuler, Ph.D.
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Duan, Bin

University Of Nebraska Medical Center
United States

Flupirtine Analogue Synthesis and Screening for the Treatment of Chemotherapy-Induced Neuropathic Pain 1R21CA298918-01 Rachel Altshuler, Ph.D.
Pozdeyev, Nikita

University Of Colorado Denver
United States

Genetic architecture of thyroid cancer and its clinical utility 5R21CA282380-02 Wendy Wang, Ph.D., M.Sc.
Peppone, Luke Joseph

University Of Rochester
United States

High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients 5R01CA258349-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Xu, Chunhui

Emory University
United States

High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes 1R21CA285254-01A1 Eileen Dimond, R.N., M.S.

Clinical Trials

Status
Title Intervention Sponsor Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online NRG Oncology Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Recruiting
Engage Psychosocial Intervention for Cancer Symptoms ENGAGE, Supportive Care Duke University Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection University of California, San Francisco Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer Androgen deprivation therapy, Flibanserin 100 MG, Placebo Andrew McDonald Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Laboratory Biomarker Analysis, Questionnaire Administration Children's Oncology Group Active, not recruiting