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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Sort descending Title Grant Number Program Official
Greene, Nicholas Perry

University Of Arkansas At Fayetteville
United States

DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA 5R01AR075794-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Brinkman, Tara M

St. Jude Children'S Research Hospital
United States

Culturally adapted mobile treatment of chronic pain in adolescent survivors of pediatric bone sarcoma 4R33CA280978-02 Rachel Altshuler, Ph.D.
Valdimarsdottir, Heiddis

Icahn School Of Medicine At Mount Sinai
United States

Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation 5R01CA260961-04 Marjorie Perloff, M.D.
Storz, Peter

Mayo Clinic Jacksonville
United States

Deiminated molecules as markers for developing pancreatic cancer - A1 5R21CA279916-02 Matthew Young, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms 5R01CA272147-03 Rachel Altshuler, Ph.D.
Rogers, Laura Q

University Of Alabama At Birmingham
United States

Role of gut microbe composition in psychosocial symptom response to exercise training in breast cancer survivors 5R01CA235598-06 Gabriela Riscuta, M.D., CNS
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Justilien, Verline

Mayo Clinic Jacksonville
United States

ECT2 Isoform Switch in Pancreatic Cancer. 5R21CA296671-02 Matthew Young, Ph.D.
Cao, Weidan

Ohio State University
United States

Treatment-Related Cardiotoxicity Risk Prediction for Breast Cancer Patients with a Multimodal AI-based System 1R01CA301579-01 Eileen Dimond, R.N., M.S.
Upshaw, Jenica

Beth Israel Deaconess Medical Center
United States

A randomized trial of cardioprotective strategies in newly diagnosed diffuse large B-cell lymphoma and pre-existing cardiomyopathy or prior anthracycline exposure 1R37CA300969-01 Eileen Dimond, R.N., M.S.
Bhatt, Vijaya Raj

University Of Nebraska Medical Center
United States

Aging trajectories and outcomes of older adults with acute myeloid leukemia 5R37CA276928-03 Brennan Streck, Ph.D., RN, M.P.H.
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Xu, Xiangxi Mike

University Of Miami School Of Medicine
United States

Countering microtubule stabilization within hair follicles in ovarian cancer chemotherapy 5R01CA286527-02 Rachel Altshuler, Ph.D.
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Status
Title Intervention Sponsor Status
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy Best Practice, Educational Intervention, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration, Text Message-based Navigation Intervention Alliance for Clinical Trials in Oncology Active, not recruiting
An Internet-based Program to Help Cancer Survivors Manage Pain Internet-based pain coping skills program Wake Forest University Health Sciences Recruiting
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics Non-interventional Study Wake Forest University Health Sciences Recruiting
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Behavioral Intervention, Compliance Monitoring, Laboratory Biomarker Analysis, Mercaptopurine, Questionnaire Administration, Standard Follow-Up Care Children's Oncology Group Active, not recruiting
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy University of Rochester NCORP Research Base Enrolling by invitation
Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection Axillary Lymph Node Dissection, Isosulfan Blue, Mapping, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Active, not recruiting
Cancer and Blood Pressure Management, CARISMA Study Best Practice, Blood Pressure Measurement, Clinical Management, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors Arm 1: Computerized Cognitive Training-Global Stimulation Games, Arm 2: Computerized Cognitive Training-Neuroplasticity Games NRG Oncology Recruiting
Communication About Sexual Health in Gynecologic Cancer Sexual Health Resources, Starting the Conversation Fox Chase Cancer Center Recruiting