Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title	Grant Number Sort descending	Program Official
Palesh, Oxana G	Virginia Commonwealth University United States	Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia	5R01CA239714-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wang, Hsiao-Lan	University Of Alabama At Birmingham United States	A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment	5R01CA244947-06	Goli Samimi, Ph.D., M.P.H.
Kolb, Noah Allan	University Of Vermont & St Agric College United States	Remote Monitoring of Management of Chemotherapy induced Peripheral Neuropathy	5R01CA247517-05	Brennan Streck, Ph.D., RN, M.P.H.
Winters-Stone, Kerri M	Oregon Health & Science University United States	Patterns and predictors of symptoms, falls, and functioning across treatment and recovery in patients treated with neurotoxic chemotherapy for cancer	5R01CA248059-05	Goli Samimi, Ph.D., M.P.H.
Shelby, Rebecca A	Duke University United States	Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis	5R01CA249959-05	Brennan Streck, Ph.D., RN, M.P.H.
Hanks, Brent Allen	Univ Of North Carolina Chapel Hill United States	Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities	5R01CA251136-06	Marjorie Perloff, M.D.
Bao, Ting	Dana-Farber Cancer Inst United States	Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial	5R01CA251470-06	Goli Samimi, Ph.D., M.P.H.
Spiegel, Brennan	Cedars-Sinai Medical Center United States	Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes	5R01CA252211-05	Rachel Altshuler, Ph.D.
Washington, Karla	Washington University United States	Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care	5R01CA258311-05	Brennan Streck, Ph.D., RN, M.P.H.
Peppone, Luke Joseph	University Of Rochester United States	High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients	5R01CA258349-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Hu, Jim	Weill Medical Coll Of Cornell Univ United States	Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)	5R01CA259173-04	Marjorie Perloff, M.D.
Valdimarsdottir, Heiddis	Icahn School Of Medicine At Mount Sinai United States	Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation	5R01CA260961-04	Marjorie Perloff, M.D.
Kroetz, Deanna L	Ohio State University United States	Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity	5R01CA261068-06	Rachel Altshuler, Ph.D.
Salvemini, Daniela	Saint Louis University United States	Fingolimod and Ozanimod for the treatment and prevention of chemobrain	5R01CA261979-04	Rachel Altshuler, Ph.D.
Huberty, Jennifer Lynne	University Of Texas Hlth Science Center United States	Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patients	5R01CA262041-05	Marjorie Perloff, M.D.

Clinical Trials

Title	Intervention	Sponsor	Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer	Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online	NRG Oncology	Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment	Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration	Children's Oncology Group	Recruiting
Engage Psychosocial Intervention for Cancer Symptoms	ENGAGE, Supportive Care	Duke University	Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors	Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT	Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection	University of California, San Francisco	Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment	Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors	Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer	Androgen deprivation therapy, Flibanserin 100 MG, Placebo	Andrew McDonald	Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	Laboratory Biomarker Analysis, Questionnaire Administration	Children's Oncology Group	Active, not recruiting