Program Official
Principal Investigator
Constance Margaret
Johnson
Awardee Organization
University Of Texas Hlth Sci Ctr Houston
United States
Fiscal Year
2023
Activity Code
R01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date
NIH RePORTER
For more information, see NIH RePORTER Project 3R01CA245054-04S1
The relationship between fMRI and patient-reported outcomes in chemotherapy-induced neuropathy: A diversity supplement
of Parent Grant (R01CA245054) Chemotherapy induced neuropathy (CIN) is a severe side effect that impacts greater than 60% of cancer patients. CIN impacts treatment duration and dosing, functional mobility, and quality of life. This proposal examines the effect of auricular point acupressure (APA) as an innovated solution for CIN. APA utilizes a non-invasive, active modality of treatment stimulating points on ear to improve CIN symptoms. Utilizing a mobile application on smartphones, this project teaches participants how to stimulate their ears for three minutes, 3 times a day to alleviate pain. Given limited understanding of the mechanism of pain relief, participants will complete multiple questionnaires: Quantitative Sensory Test, Revised Brief Pain Inventory-CIN, PROMIS29, Opioid Use, Experience and Attitude, and Demographic data. Additionally, imaging studies and biomarkers will be obtained. Functional MRI (fMRIs) will obtain pre-, post-, and follow-up APA evoked signal changes and pro- and anti- inflammatory cytokines will be collected. The goal of this study is to ascertain the efficacy of APA as a self-managed, adjunctive therapy to enhance CIN management, through understanding the underlying mechanisms of APA on CIN.
Publications
- Kawi J, Yeh CH, Li M, Caswell Bs K, Mazraani Md M, Lukkahatai PhD Rn N, Mensah Rn S, Taylor J, Budhathoki C, Christo P. Auricular Point Acupressure Smartphone Application to Manage Chronic Musculoskeletal Pain: A Longitudinal, One-Group, Open Pilot Trial. Global advances in health and medicine. 2021 Jan 22;10:2164956120987531. doi: 10.1177/2164956120987531. eCollection 2021. PMID: 33623727
Clinical Trials
Study Name | Clinical Trial ID |
---|---|
Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy | NCT04920097 |