Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title	Grant Number	Program Official
Kelleher, Sarah	Duke University United States	Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients	5R01CA291888-02	Brennan Streck, Ph.D., RN, M.P.H.
Santomasso, Bianca Denise	Sloan-Kettering Inst Can Research United States	Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy	5R01CA293922-02	Monica Epstein, B.S.N., RN, OCN
Ligibel, Jennifer A.	Dana-Farber Cancer Inst United States	Distance-based Exercise to preserve Function and prevENt Disability (DEFEND)	5U34CA293568-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Knoerl, Robert James	University Of Michigan At Ann Arbor United States	Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.	5R34CA286712-02	Goli Samimi, Ph.D., M.P.H.
Jim, Heather S.L.	H. Lee Moffitt Cancer Ctr & Res Inst United States	Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer	5R34CA289918-02	Brennan Streck, Ph.D., RN, M.P.H.
Lehto, Rebecca H	Henry Ford Health + Michigan State University Health Sciences United States	Support for bereaved friend and family caregivers of cancer patients	1R03CA282943-01A1	Brennan Streck, Ph.D., RN, M.P.H.
Shiozawa, Yusuke	Wake Forest University Health Sciences United States	Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy	1R21CA297068-01	Rachel Altshuler, Ph.D.
Justilien, Verline	Mayo Clinic Jacksonville United States	ECT2 Isoform Switch in Pancreatic Cancer.	1R21CA296671-01	Matthew Young, Ph.D.
Damaj, M. Imad	Virginia Commonwealth University United States	Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy	1R21CA296516-01	Rachel Altshuler, Ph.D.
Grossman, Douglas	University Of Utah United States	Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma	1R21CA289101-01A1	Nicholas Hodges, Ph.D.
Ah, Diane Marie Von	Ohio State University United States	Cognitive Training for Cancer-related Cognitive Impairment: A Multi-Center Randomized Controlled Trial	5R01CA276222-03	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kang, Dongkyun	University Of Arizona United States	Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy	1R01CA301271-01	Rachel Altshuler, Ph.D.
Clare, Susan E.	Northwestern University At Chicago United States	Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype	1R21CA288676-01A1
Pistilli, Emidio Edward	West Virginia University United States	Targeting Muscle Fatigability During Cachexia	5R01AR079445-04	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Greene, Nicholas Perry	University Of Arkansas At Fayetteville United States	DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA	5R01AR075794-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Title Sort ascending	Intervention	Sponsor	Status
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	Laboratory Biomarker Analysis, Questionnaire Administration	Children's Oncology Group	Active, not recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer	Androgen deprivation therapy, Flibanserin 100 MG, Placebo	Andrew McDonald	Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors	Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment	Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT	Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection	University of California, San Francisco	Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors	Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Recruiting
Engage Psychosocial Intervention for Cancer Symptoms	ENGAGE, Supportive Care	Duke University	Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment	Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration	Children's Oncology Group	Recruiting
E-Mindfulness Approaches for Living After Breast Cancer	Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online	NRG Oncology	Recruiting
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting