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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Hui, David

University Of Tx Md Anderson Can Ctr
United States

Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology 5R01CA288515-02 Brennan Streck, Ph.D., RN, M.P.H.
Zhu, Yong

Univ Of Arkansas For Med Scis
United States

Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection 1R21CA277412-01A1 Christos Patriotis, Ph.D., M.Sc.
Bower, Julienne E

University Of California Los Angeles
United States

Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings 5R01CA282416-02 Brennan Streck, Ph.D., RN, M.P.H.
Mosher, Catherine E

Indiana University Indianapolis
United States

Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer 5R01CA289486-02
Cohen, Lorenzo

University Of Tx Md Anderson Can Ctr
United States

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery 5R01CA272565-03 Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue 5R01CA214647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Rogers, Laura Q

University Of Alabama At Birmingham
United States

Role of gut microbe composition in psychosocial symptom response to exercise training in breast cancer survivors 5R01CA235598-06 Gabriela Riscuta, M.D., CNS
Herrmann, Joerg

Mayo Clinic Rochester
United States

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial 5R01CA233610-06 Eileen Dimond, R.N., M.S.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 7R01CA251136-05 Marjorie Perloff, M.D.
Sedrak, Mina S

University Of California Los Angeles
United States

Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline 5R01CA280088-03 Goli Samimi, Ph.D., M.P.H.
Peppone, Luke Joseph

University Of Rochester
United States

High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients 5R01CA258349-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wang, Hsiao-Lan

University Of Alabama At Birmingham
United States

A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment 5R01CA244947-06 Goli Samimi, Ph.D., M.P.H.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Hu, Shuiying

Ohio State University
United States

Targeting neuronal transport to ameliorate vincristine neurotoxicity 5R01CA272254-03 Rachel Altshuler, Ph.D.
Khasabov, Sergey G

University Of Minnesota
United States

Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling 5R01CA263777-05 Rachel Altshuler, Ph.D.

Clinical Trials

Status
Title Sort descending Intervention Sponsor Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online NRG Oncology Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Recruiting
Engage Psychosocial Intervention for Cancer Symptoms ENGAGE, Supportive Care Duke University Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection University of California, San Francisco Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer Androgen deprivation therapy, Flibanserin 100 MG, Placebo Andrew McDonald Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Laboratory Biomarker Analysis, Questionnaire Administration Children's Oncology Group Active, not recruiting