Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title	Grant Number	Program Official Sort descending
Sohl, Stephanie Jean	Wake Forest University Health Sciences United States	REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE)	5R01CA266995-04	Goli Samimi, Ph.D., M.P.H.
Sedrak, Mina S	University Of California Los Angeles United States	Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline	5R01CA280088-03	Goli Samimi, Ph.D., M.P.H.
Shelby, Rebecca A	Duke University United States	Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention	1R21CA301298-01	Goli Samimi, Ph.D., M.P.H.
Deng, Gary E	University Of California-Irvine United States	Acupuncture to Improve Outcomes in Patients with Sepsis: a Randomized Controlled Trial	7R21CA286330-03	Goli Samimi, Ph.D., M.P.H.
Wang, Hsiao-Lan	University Of Alabama At Birmingham United States	A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment	5R01CA244947-06	Goli Samimi, Ph.D., M.P.H.
Wright, Alexi A	Dana-Farber Cancer Inst United States	Randomized trial of REVITALIZE: A telehealth intervention to reduce fatigue interference among adults with advanced ovarian cancer on PARP inhibitors	5R01CA289547-02	Goli Samimi, Ph.D., M.P.H.
Marker, Ryan J	University Of Colorado Denver United States	Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation	5R01CA292482-02	Goli Samimi, Ph.D., M.P.H.
Bao, Ting	Dana-Farber Cancer Inst United States	Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial	5R01CA251470-06	Goli Samimi, Ph.D., M.P.H.
Knoerl, Robert James	University Of Michigan At Ann Arbor United States	Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.	5R34CA286712-02	Goli Samimi, Ph.D., M.P.H.
Nolan, Michael Warren	North Carolina State University Raleigh United States	Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer	5R37CA248797-05	Asad Umar, D.V.M., Ph.D.
Mehrara, Babak J	Sloan-Kettering Inst Can Research United States	Mechanisms of racial disparity in breast cancer-related lymphedema	5R01CA278599-04	Asad Umar, D.V.M., Ph.D.
Elswick, Ronald K	Virginia Commonwealth University United States	A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer	5R01CA286799-03	Asad Umar, D.V.M., Ph.D.
Penedo, Frank J	University Of Miami Coral Gables United States	eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant Patients	4R33CA263335-03	Asad Umar, D.V.M., Ph.D.
Plas, Ellen Van Der	Arkansas Children'S Hospital Res Inst United States	Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia	5R37CA266135-04	Asad Umar, D.V.M., Ph.D.
Fuschiotti, Patrizia	University Of Pittsburgh At Pittsburgh United States	Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides	5R21CA280445-02	Wendy Wang, Ph.D., M.Sc.

Clinical Trials

Title	Intervention	Sponsor	Status
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program	Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention	Alliance for Clinical Trials in Oncology	Recruiting