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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official Sort descending
Chong, Catherine Daniela

Mayo Clinic Arizona
United States

Biomarker Signature to Predict the Persistence of Post-Traumatic Headache 5R33NS113315-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Palesh, Oxana G

Virginia Commonwealth University
United States

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia 5R01CA239714-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ligibel, Jennifer A.

Dana-Farber Cancer Inst
United States

Distance-based Exercise to preserve Function and prevENt Disability (DEFEND) 5U34CA293568-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Gill, Brian John Andrew

Columbia University Health Sciences
United States

The Impact of Local and Reversible Change to GABAergic Inhibitory Signaling on Tumor-Induced Cortical Dysfunction in Glioma 1R01NS140658-01A1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Taratula, Oleh

Oregon State University
United States

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia 5R37CA234006-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Li, Feng

University Of California Los Angeles
United States

Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer. 5R21CA283665-02 Guillermo Marquez, Ph.D.
Lesch, Bluma J

Yale University
United States

Defining signatures of epigenetic sensitization to lung cancer in a mouse model 5R21CA288677-02 Guillermo Marquez, Ph.D.
Zhu, Yong

Univ Of Arkansas For Med Scis
United States

Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection 1R21CA277412-01A1 Christos Patriotis, Ph.D., M.Sc.
Morin, Olivier

University Of California, San Francisco
United States

Development of a Personalized Voxel-wise Prediction of Brain Metastases using Multi-Parametric MR Imaging to Reduce Treatment Toxicity 1R01CA292043-01A1 Marjorie Perloff, M.D.
Infante, Rodney E

Ut Southwestern Medical Center
United States

Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia 3R01CA266900-04S1 Marjorie Perloff, M.D.
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.
Boone, Anna

University Of Missouri-Columbia
United States

Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer 1R21CA286404-01A1 Marjorie Perloff, M.D.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 5R01CA251136-06 Marjorie Perloff, M.D.
Nelson, Randy J.

West Virginia University
United States

Mechanism Underlying Sleep Disruption by Mammary Tumors 5R21CA276027-02 Marjorie Perloff, M.D.
Valdimarsdottir, Heiddis

Icahn School Of Medicine At Mount Sinai
United States

Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation 5R01CA260961-04 Marjorie Perloff, M.D.

Clinical Trials

Status
Title Intervention Sponsor Status
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial Best Practice, Comprehensive Geriatric Assessment, Educational Intervention, Exercise Intervention, Questionnaire Administration, Tailored Intervention University of Rochester Recruiting
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors Aerobic Exercise Training, Attention Control University of Alabama at Birmingham Active, not recruiting
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care Haloperidol, Lorazepam, Placebo, Quality-of-Life Assessment, Questionnaire Administration M.D. Anderson Cancer Center Active, not recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors Biospecimen Collection, Questionnaire Administration SWOG Cancer Research Network Recruiting
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer Biospecimen Collection, Diagnostic Imaging Testing, Excisional Biopsy, Indocyanine Green Solution, Minimally Invasive Surgery, Pelvic Lymphadenectomy, Questionnaire Administration, Sentinel Lymph Node Mapping NRG Oncology Recruiting
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials Questionnaires Eastern Cooperative Oncology Group Recruiting
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making Usual Care, Web-based decision aid Alliance for Clinical Trials in Oncology Active, not recruiting
IVIG for Infection Prevention After CAR-T-Cell Therapy Anti-CD19 CAR T Cells Preparation, Biospecimen Collection, Electronic Health Record Review, Immune Globulin Infusion (Human), 10% Solution, Saline, Survey Administration Fred Hutchinson Cancer Center Recruiting
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Lactobacillus plantarum strain 299, Lactobacillus plantarum strain 299v, Placebo Administration Children's Oncology Group Active, not recruiting
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula Biospecimen Collection, Distal Pancreatectomy, Lanreotide, Questionnaire Administration, Saline SWOG Cancer Research Network Recruiting