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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official Sort descending
Yu, Anthony Francis

Sloan-Kettering Inst Can Research
United States

Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial 5R37CA273923-03 Eileen Dimond, R.N., M.S.
Webster, Nicholas J

Veterans Medical Research Fdn/San Diego
United States

The Effect of Time-Restricted Eating on the Efficiency of Chemo- and Hormonal-Therapy in Breast Cancer 5R21CA288777-02 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Crowder, Sylvia

H. Lee Moffitt Cancer Ctr & Res Inst
United States

The MIND-BC Study: MIND diet for Breast cancer Cognition 1R01CA299480-01 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue 5R01CA214647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kober, Kord Michael

University Of California, San Francisco
United States

An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach 5R37CA233774-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Judge, Andrew Robert

University Of Florida
United States

The Complement System and Cancer Cachexia 5R01AR081648-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Flynn, Kathryn E

Medical College Of Wisconsin
United States

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM) 5R01CA285925-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ah, Diane Marie Von

Ohio State University
United States

Cognitive Training for Cancer-related Cognitive Impairment: A Multi-Center Randomized Controlled Trial 5R01CA276222-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Gonzalez, Brian D

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment 5R01CA287666-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Peppone, Luke Joseph

University Of Rochester
United States

High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients 5R01CA258349-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Pistilli, Emidio Edward

West Virginia University
United States

Targeting Muscle Fatigability During Cachexia 5R01AR079445-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Greene, Nicholas Perry

University Of Arkansas At Fayetteville
United States

DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA 5R01AR075794-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kleckner, Amber Simmons

University Of Maryland Baltimore
United States

Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies 5R01CA284082-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chong, Catherine Daniela

Mayo Clinic Arizona
United States

Biomarker Signature to Predict the Persistence of Post-Traumatic Headache 5R33NS113315-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Status
Title Intervention Sponsor Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online NRG Oncology Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Recruiting
Engage Psychosocial Intervention for Cancer Symptoms ENGAGE, Supportive Care Duke University Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection University of California, San Francisco Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer Androgen deprivation therapy, Flibanserin 100 MG, Placebo Andrew McDonald Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Laboratory Biomarker Analysis, Questionnaire Administration Children's Oncology Group Active, not recruiting