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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official Sort descending
Pfleger, Cathie M

Icahn School Of Medicine At Mount Sinai
United States

A Drosophila model for Aromatase Inhibitor-induced Musculoskeletal Pain 1R21CA303409-01 Rachel Altshuler, Ph.D.
Brown, Austin L

Baylor College Of Medicine
United States

A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia 5R01CA272981-03 Rachel Altshuler, Ph.D.
Shiozawa, Yusuke

Wake Forest University Health Sciences
United States

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy 1R21CA297068-01 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms 5R01CA272147-03 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 1R21CA296516-01 Rachel Altshuler, Ph.D.
Chan, Alexandre

University Of California-Irvine
United States

Neurotrophic strategy to mitigate chemotherapy-related brain injury 5R01CA276212-03 John Clifford, Ph.D.
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.
Mahan, Kristin Eckel

University Of Texas Hlth Sci Ctr Houston
United States

Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain 1R21CA292148-01 John Clifford, Ph.D.
Morilak, David A

University Of Texas Hlth Science Center
United States

Therapy-induced cognitive impairment in a rat model of prostate cancer 5R01CA285183-03 John Clifford, Ph.D.
Phillips, Nicholas S

St. Jude Children'S Research Hospital
United States

Cardiopulmonary function and cerebral blood flow in Hodgkin Lymphoma survivors 5R21CA280230-02 Eileen Dimond, R.N., M.S.
Herrmann, Joerg

Mayo Clinic Rochester
United States

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial 5R01CA233610-06 Eileen Dimond, R.N., M.S.
Yu, Anthony Francis

Sloan-Kettering Inst Can Research
United States

Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial 5R37CA273923-03 Eileen Dimond, R.N., M.S.
Xu, Chunhui

Emory University
United States

High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes 1R21CA285254-01A1 Eileen Dimond, R.N., M.S.
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.

Clinical Trials

Status
Title Intervention Sponsor Status
Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment Behavioral Intervention, Electronic Health Record Review, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Recruiting
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy, Quality-of-Life Assessment, Questionnaire Administration SWOG Cancer Research Network Recruiting
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy fractionated stereotactic radiosurgery (FSRS), single fraction stereotactic radiosurgery (SSRS) Wake Forest University Health Sciences Recruiting
Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment Counseling, Health Education, Interview, Medical Chart Review, Monitoring, Questionnaire Administration NRG Oncology Recruiting
Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy Cognitive Assessment, Computer-Assisted Cognitive Training, Psychosocial Assessment and Care, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Active, not recruiting
Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia Acupuncture - Group 1, Acupuncture - Group 2, Questionnaire, Standard Care M.D. Anderson Cancer Center Active, not recruiting
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM) Best Practice, Financial Navigation, Interview, Survey Administration ECOG-ACRIN Cancer Research Group Recruiting
Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial Internet-based Intervention Wake Forest University Health Sciences Active, not recruiting
Dexamethasone in Controlling Dyspnea in Patients With Cancer Dexamethasone, Questionnaire Administration, Placebo M.D. Anderson Cancer Center Active, not recruiting
Distance-Based Exercise to Preserve Function and Prevent Disability Accelerometry, Aerobic Exercise Intervention, Dumbbell Exercise Intervention, Electronic Health Record Review, Exercise intervention, Interview, Questionnaire Administration, Telemedicine Alliance for Clinical Trials in Oncology Not yet recruiting