Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name	PI Organization Sort descending	Title	Grant Number	Program Official
Kang, Dongkyun	University Of Arizona United States	Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy	1R01CA301271-01	Rachel Altshuler, Ph.D.
Shelby, Rebecca A	Duke University United States	Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention	1R21CA301298-01	Goli Samimi, Ph.D., M.P.H.
Im, Eun-Ok	University Of Texas At Austin United States	Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors	5R33CA280979-04	Brennan Streck, Ph.D., RN, M.P.H.
Infante, Rodney E	Ut Southwestern Medical Center United States	Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia	3R01CA266900-04S1	Marjorie Perloff, M.D.
Bryan, Angela	University Of Colorado United States	Cannabis for Palliative Care in Cancer: A Placebo-controlled Randomized Trial of Full Spectrum Hemp-derived CBD/THC	5R01CA284860-03	Brennan Streck, Ph.D., RN, M.P.H.
Melemedjian, Ohannes Kevork	University Of Maryland Baltimore United States	Identification of novel targets for the treatment of chemotherapy-induced painful peripheral neuropathy	4R01CA249939-02	Rachel Altshuler, Ph.D.
Mosher, Catherine E	Indiana University Indianapolis United States	Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer	5R01CA289486-02
Huberty, Jennifer Lynne	University Of Texas Hlth Science Center United States	Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patients	5R01CA262041-05	Marjorie Perloff, M.D.
Mahan, Kristin Eckel	University Of Texas Hlth Sci Ctr Houston United States	Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain	1R21CA292148-01	John Clifford, Ph.D.
Jim, Heather S.L.	H. Lee Moffitt Cancer Ctr & Res Inst United States	Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer	5R34CA289918-02	Brennan Streck, Ph.D., RN, M.P.H.
Groninger, J. Hunter	Medstar Health Research Institute United States	Cognitive behavioral theory-assisted virtual reality for chronic cancer pain (VR-CAN): device prototype development and feasibility testing	1R21CA299799-01	Brennan Streck, Ph.D., RN, M.P.H.
Prigerson, Holly Gwen	Weill Medical Coll Of Cornell Univ United States	Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)	5R35CA197730-11	Brennan Streck, Ph.D., RN, M.P.H.
Milbury, Kathrin	University Of Tx Md Anderson Can Ctr United States	Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers	4R37CA231522-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ross, Stephen	New York University School Of Medicine United States	Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress	5R01CA268521-04	Rachel Altshuler, Ph.D.
Pozdeyev, Nikita	University Of Colorado Denver United States	Genetic architecture of thyroid cancer and its clinical utility	5R21CA282380-02	Wendy Wang, Ph.D., M.Sc.

Clinical Trials

Title	Intervention	Sponsor	Status
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program	Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention	Alliance for Clinical Trials in Oncology	Recruiting