Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization Sort descending	Title	Grant Number	Program Official
Elswick, Ronald K	Virginia Commonwealth University United States	A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer	5R01CA286799-03	Asad Umar, D.V.M., Ph.D.
Garcia, Jose M.	Seattle Inst For Biomedical/Clinical Res United States	SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT)	5R01CA279220-03	Marjorie Perloff, M.D.
Morilak, David A	University Of Texas Hlth Science Center United States	Therapy-induced cognitive impairment in a rat model of prostate cancer	5R01CA285183-03	John Clifford, Ph.D.
Melemedjian, Ohannes Kevork	University Of Maryland Baltimore United States	Identification of novel targets for the treatment of chemotherapy-induced painful peripheral neuropathy	4R01CA249939-02	Rachel Altshuler, Ph.D.
Mosher, Catherine E	Indiana University Indianapolis United States	Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer	5R01CA289486-02
Taratula, Oleh	Oregon State University United States	Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia	5R37CA234006-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Yang, Qing	University Of Texas Med Br Galveston United States	The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy	5R01CA273001-02	Rachel Altshuler, Ph.D.
Lehto, Rebecca H	Henry Ford Health + Michigan State University Health Sciences United States	Support for bereaved friend and family caregivers of cancer patients	1R03CA282943-01A1	Brennan Streck, Ph.D., RN, M.P.H.
Pfleger, Cathie M	Icahn School Of Medicine At Mount Sinai United States	A Drosophila model for Aromatase Inhibitor-induced Musculoskeletal Pain	1R21CA303409-01	Rachel Altshuler, Ph.D.
Hu, Jim	Weill Medical Coll Of Cornell Univ United States	Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)	5R01CA259173-04	Marjorie Perloff, M.D.
Pyter, Leah M	Ohio State University United States	Chemotherapy-induced circadian master clock disruptions and fatigue	5R01CA270372-04	Marjorie Perloff, M.D.
Paus, Ralf	University Of Miami School Of Medicine United States	Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia	1R21CA277418-01A1	Rachel Altshuler, Ph.D.
Pozdeyev, Nikita	University Of Colorado Denver United States	Genetic architecture of thyroid cancer and its clinical utility	5R21CA282380-02	Wendy Wang, Ph.D., M.Sc.
Hu, Shuiying	Ohio State University United States	Targeting neuronal transport to ameliorate vincristine neurotoxicity	5R01CA272254-03	Rachel Altshuler, Ph.D.
Kanarek, Naama	Boston Children'S Hospital United States	Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF	5R01CA282477-02	John Clifford, Ph.D.

Clinical Trials

Title	Intervention	Sponsor	Status
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program	Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention	Alliance for Clinical Trials in Oncology	Recruiting