Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization Sort descending	Title	Grant Number	Program Official
Hall, Daniel Lee	Massachusetts General Hospital United States	Innovating CBT-I for Cancer Survivors: An Optimization Trial	5R21CA279248-02
Morin, Olivier	University Of California, San Francisco United States	Development of a Personalized Voxel-wise Prediction of Brain Metastases using Multi-Parametric MR Imaging to Reduce Treatment Toxicity	1R01CA292043-01A1	Marjorie Perloff, M.D.
Washington, Karla	Washington University United States	Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care	5R01CA258311-05	Brennan Streck, Ph.D., RN, M.P.H.
Winters-Stone, Kerri M	Oregon Health & Science University United States	Patterns and predictors of symptoms, falls, and functioning across treatment and recovery in patients treated with neurotoxic chemotherapy for cancer	5R01CA248059-05	Goli Samimi, Ph.D., M.P.H.
Mclouth, Laurie	University Of Kentucky United States	Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment	5R01CA283929-03	Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.	H. Lee Moffitt Cancer Ctr & Res Inst United States	Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue	5R01CA214647-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Li, Feng	University Of California Los Angeles United States	Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.	5R21CA283665-02	Guillermo Marquez, Ph.D.
Kleckner, Amber Simmons	University Of Maryland Baltimore United States	Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies	5R01CA284082-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Chong, Catherine Daniela	Mayo Clinic Arizona United States	Biomarker Signature to Predict the Persistence of Post-Traumatic Headache	5R33NS113315-03	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Rini, Christine	Northwestern University At Chicago United States	Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial	5R01CA271220-04	Brennan Streck, Ph.D., RN, M.P.H.
Yu, Anthony Francis	Sloan-Kettering Inst Can Research United States	Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial	5R37CA273923-03	Eileen Dimond, R.N., M.S.
Sands, Stephen Alan	Sloan-Kettering Inst Can Research United States	Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)	5R01CA283045-02	Marjorie Perloff, M.D.
Lee, Richard T	Beckman Research Institute/City Of Hope United States	A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy	1R21CA260447-01A1	Rachel Altshuler, Ph.D.
Khasabov, Sergey G	University Of Minnesota United States	Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling	5R01CA263777-05	Rachel Altshuler, Ph.D.
John, Esther M.	Stanford University United States	Stress, inflammation, and health-related quality of life of long-term breast cancer survivors	1R21CA290430-01	Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer	Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online	NRG Oncology	Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment	Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration	Children's Oncology Group	Recruiting
Engage Psychosocial Intervention for Cancer Symptoms	ENGAGE, Supportive Care	Duke University	Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors	Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT	Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection	University of California, San Francisco	Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment	Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors	Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer	Androgen deprivation therapy, Flibanserin 100 MG, Placebo	Andrew McDonald	Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	Laboratory Biomarker Analysis, Questionnaire Administration	Children's Oncology Group	Active, not recruiting