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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Sort descending Title Grant Number Program Official
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.
Mao, Jun J

Sloan-Kettering Inst Can Research
United States

Enhanced Pain Coping in Cancer (EPIC) 5R01CA285746-02 Rachel Altshuler, Ph.D.
Kelleher, Sarah

Duke University
United States

Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients 5R01CA291888-02 Brennan Streck, Ph.D., RN, M.P.H.
Duvall, Adam S.

University Of Chicago
United States

Tailoring a fun and engaging tech-assisted cognitive behavioral therapy program for adolescents and young adults with hematological malignancies: A planning grant 1R34CA297498-01 Brennan Streck, Ph.D., RN, M.P.H.
Judge, Andrew Robert

University Of Florida
United States

The Complement System and Cancer Cachexia 5R01AR081648-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Washington, Karla

Washington University
United States

Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care 5R01CA258311-05 Brennan Streck, Ph.D., RN, M.P.H.
Storz, Peter

Mayo Clinic Jacksonville
United States

Deiminated molecules as markers for developing pancreatic cancer - A1 5R21CA279916-02 Matthew Young, Ph.D.
Fuschiotti, Patrizia

University Of Pittsburgh At Pittsburgh
United States

Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides 5R21CA280445-02 Wendy Wang, Ph.D., M.Sc.
Hanks, Brent Allen

Univ Of North Carolina Chapel Hill
United States

Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities 5R01CA251136-06 Marjorie Perloff, M.D.
Nelson, Randy J.

West Virginia University
United States

Mechanism Underlying Sleep Disruption by Mammary Tumors 5R21CA276027-02 Marjorie Perloff, M.D.
Winger, Joseph Giles

Duke University
United States

Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer 5R01CA291768-02 Brennan Streck, Ph.D., RN, M.P.H.
Grossman, Douglas

Utah State Higher Education System--University Of Utah
United States

Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma 5R21CA289101-02 Nicholas Hodges, Ph.D.
Eisenmann, Eric Daniel

Ohio State University
United States

Damage-associated molecular patterns in chemotherapy toxicity 1R37CA299879-01 Rachel Altshuler, Ph.D.
Vijayvergia, Namrata

Research Inst Of Fox Chase Can Ctr
United States

Exploring the Neuroprotective Potential of CBD in Preventing Oxaliplatin-Induced Neuropathy: A Prospective Study 1R21CA292276-01A1 Rachel Altshuler, Ph.D.
Bhatt, Vijaya Raj

University Of Nebraska Medical Center
United States

Aging trajectories and outcomes of older adults with acute myeloid leukemia 5R37CA276928-03 Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Status
Title Intervention Sponsor Status
Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment Behavioral Intervention, Electronic Health Record Review, Quality-of-Life Assessment, Questionnaire Administration University of Rochester NCORP Research Base Recruiting
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy, Quality-of-Life Assessment, Questionnaire Administration SWOG Cancer Research Network Recruiting
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy fractionated stereotactic radiosurgery (FSRS), single fraction stereotactic radiosurgery (SSRS) Wake Forest University Health Sciences Recruiting
Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment Counseling, Health Education, Interview, Medical Chart Review, Monitoring, Questionnaire Administration NRG Oncology Recruiting
Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy Cognitive Assessment, Computer-Assisted Cognitive Training, Psychosocial Assessment and Care, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Active, not recruiting
Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia Acupuncture - Group 1, Acupuncture - Group 2, Questionnaire, Standard Care M.D. Anderson Cancer Center Active, not recruiting
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM) Best Practice, Financial Navigation, Interview, Survey Administration ECOG-ACRIN Cancer Research Group Recruiting
Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial Internet-based Intervention Wake Forest University Health Sciences Active, not recruiting
Dexamethasone in Controlling Dyspnea in Patients With Cancer Dexamethasone, Questionnaire Administration, Placebo M.D. Anderson Cancer Center Active, not recruiting
Distance-Based Exercise to Preserve Function and Prevent Disability Accelerometry, Aerobic Exercise Intervention, Dumbbell Exercise Intervention, Electronic Health Record Review, Exercise intervention, Interview, Questionnaire Administration, Telemedicine Alliance for Clinical Trials in Oncology Not yet recruiting